Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Mammary Cell News
Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.
A Glycolytic Metabolite Bypasses “Two-Hit” Tumor Suppression by BRCA2
[Cell] The authors reported that the glycolytic metabolite methylglyoxal transiently bypasses Knudson’s paradigm by inactivating the breast cancer suppressor protein BRCA2 to elicit a cancer-associated, mutational single-base substitution signature in nonmalignant mammary cells or patient-derived organoids.
COL5A1 Promotes Triple-Negative Breast Cancer Progression by Activating Tumor Cell-Macrophage Crosstalk
[Oncogene] Scientists reported that upregulation of collagen type V alpha 1 (COL5A1) in TNBC tissues, particularly in chemoresistant samples, was closely linked to an unfavorable prognosis.
RUVBL1 Ubiquitination by DTL Promotes RUVBL1/2-β-Catenin-Mediated Transcriptional Regulation of NHEJ Pathway and Enhances Radiation Resistance in Breast Cancer
[Cell Death & Disease] Investigators revealed that RUVBL1 was excessively expressed in mouse models undergoing radiotherapy, which is considered a murine spontaneous breast-tumor model. RUVBL1 enhanced DNA damage repair and radioresistance in breast cancer cells both in vitro and in vivo.
Neratinib Could Be Effective As Monotherapy or in Combination With Trastuzumab in HER2-Low Breast Cancer Cells and Organoid Models
[British Journal Of Cancer] The authors investigated the effect of trastuzumab monotherapy and its combination with different HER2 targeting treatments in a panel of breast cancer cell lines and patient-derived organoids using biochemical methods and cell viability assays.
Sprouty Genes Regulate Activated Fibroblasts in Mammary Epithelial Development and Breast Cancer
[Cell Death & Disease] Investigators showed in mammary stromal fibroblasts that loss of the receptor tyrosine kinase (RTK) negative feedback regulators encoded by Spry1, Spry2, and Spry4 causes upregulation of signaling in multiple RTK pathways and increased extracellular matrix remodeling, resulting in accelerated epithelial branching.
Recent Developments in Targeting Breast Cancer Stem Cells (BCSCs): A Descriptive Review of Therapeutic Strategies and Emerging Therapies
[Medical Oncology] The authors summarize evolving strategies to target BCSCs, which have become a pivotal aspect of therapeutic development. They explore a variety of approaches, including targeting specific tumor surface markers, transporters, heat shock proteins, and critical signaling pathways like Notch, Akt, Hedgehog, KLF4, and Wnt/β-catenin.
Roche Obtains CE Mark for First Companion Diagnostic To Identify Patients with HER2-Low Metastatic Breast Cancer Eligible for ENHERTU
[F. Hoffmann-La Roche AG (BioSpace)] Roche announced the approval of the CE Mark for the VENTANA® HER2 Rabbit Monoclonal Primary Antibody RxDx* to identify metastatic breast cancer patients with low HER2 expression for whom ENHERTU® may be considered as a targeted treatment.
Texas A&M, University of Colorado Research Collaboration Wins Federal Grant To Help Turn Off ‘Breast Cancer Switch’
[Texas A&M University] Researchers at the Texas A&M School of Veterinary Medicine & Biomedical Sciences and the University of Colorado Cancer Center have received a $3.3 million grant from the National Institutes of Health to study how a pair of molecules that regulate certain types of metastatic breast cancer interact with a new drug therapy.
Selective Impact of ALK and MELK Inhibition on ERα Stability and Cell Proliferation in Cell Lines Representing Distinct Molecular Phenotypes of Breast Cancer
[Scientific Reports] Using classical signal transduction and cell proliferation methods, along with multiple breast cancer cell lines, scientists identified enhanced sensitivity of ERα-positive breast cancer cell lines to anaplastic lymphoma kinase (ALK) and maternal embryonic leucine zipper kinase (MELK) inhibitors, inducing ERα degradation and diminishing proliferation in specific breast cancer subtypes.
MILIP Binding to tRNAs Promotes Protein Synthesis To Drive Triple-Negative Breast Cancer
[Cancer Research] Scientists reported that the long noncoding RNA MILIP supported TNBC cell survival, proliferation, and tumorigenicity by complexing with transfer RNAs (tRNA) to promote protein production, thus representing a potential therapeutic target in TNBC.
Genetic Interactions Reveal Distinct Biological and Therapeutic Implications in Breast Cancer
[Cancer Cell] Researchers investigated a large-scale multi-omics cohort and a real-world clinical sequencing cohort including several clinical trials with detailed treatment outcomes, and performed functional validation in patient-derived organoids, tumor fragments, and in vivo models.
IRX4204 Induces Senescence and Cell Death in HER2-Positive Breast Cancer and Synergizes with Anti-HER2 Therapy
[Clinical Cancer Research] Scientists examined the efficacy of IRX4204, a highly specific rexinoid, in breast cancer cell lines and preclinical models to identify a biomarker for response and potential mechanism of action.
For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.
