Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Procoagulant Platelets Promote Immune Evasion in Triple Negative Breast Cancer

April 23, 2024

[Blood] Scientists reported that procoagulant platelets beared large amounts of such immunomodulatory factors and that the presence of these cellular blood components in TNBC related to pro-tumorigenic immune cell activity and impaired survival.

Lysophosphatidic Acid Receptor 1 (LPA1) Antagonists As Potential Migrastatics for Triple Negative Breast Cancer

April 23, 2024

[ChemMedChem] Researchers reported the synthesis and biological evaluation of fluorine-containing triazole derivatives as potent lysophosphatidic acid receptor 1 (LPA1) antagonists, offering potential as migrastatic drugs for triple negative breast cancer.

The Ras-Related Protein RAB22A Interacts with Hypoxia-Inducible Factor 1-Alpha (HIF-1α) in MDA-MB-231 Breast Cancer Cells in Hypoxia

April 23, 2024

[Molecular Biology Reports] Investigators determined whether these two proteins are present in intracellular complexes in breast carcinoma cells. Evaluation using molecular docking indicated that HIF-1α and RAB22A interact with each other.

68Ga Labeled EphA2-Targeted Cyclic Peptide: A Novel Positron Imaging Tracer for Triple-Negative Breast Cancer?

April 23, 2024

[Dalton Transactions] To develop a novel PET imaging agent, we prepared gallium-68 (68Ga) labeled-DOTA-SD01 and evaluated its specificity and effectiveness through micro PET/CT imaging in a TNBC-bearing mouse model.

UFL1 Triggers Replication Fork Degradation by MRE11 in BRCA1/2-Deficient Cells

April 22, 2024

[Nature Chemical Biology] Investigators identified UFL1, a UFM1-specific E3 ligase, as a pivotal regulator of fork stability and the response to PARP inhibitors in BRCA1/2-deficient cells.

Global Breast Cancer Report Finds Inequities Persist

April 18, 2024

[National Institute for Health and Care Research] A new Lancet Commission sets out recommendations to tackle urgent global challenges in breast cancer. Supported by the National Institute for Health and Care Research, the commission reveals that despite significant improvements inequities persist.

Physiological DNA Damage Promotes Functional Endoreplication of Mammary Gland Alveolar Cells During Lactation

April 17, 2024

[Nature Communications] Researchers showed that DNA damage accumulates due to replication stress during pregnancy, activating the DNA damage response. Modulation of DNA damage levels in vivo by intraductal injections of nucleosides or DNA damaging agents reveals that the degree of DNA damage accumulated during pregnancy governs endoreplication and milk production.

Epigenetic Deregulation in Breast Cancer Microenvironment: Implications for Tumor Progression and Therapeutic Strategies

April 17, 2024

[Biomedicine & Pharmacotherapy] Scientists delve into the complex connections between breast cancer treatment response, underlying epigenetic changes, and vital interactions within the tumor microenvironment.

CDK7 in Breast Cancer: Mechanisms of Action and Therapeutic Potential

April 17, 2024

[Cell Communication And Signaling] Scientists delineated the biological roles of CDK7 and explicates the molecular pathways through which CDK7 exacerbates the oncogenic progression of breast cancer.

ANXA9 Facilitates S100A4 and Promotes Breast Cancer Progression through Modulating STAT3 Pathway

April 17, 2024

[Cell Death Discovery] Researchers found highly expressed ANXA9 in metastatic breast cancer tissues, which is correlated with breast cancer progression. In vitro, the functional experiments indicated ANXA9 influenced breast cancer proliferation, motility, invasion, and apoptosis

IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy

April 17, 2024

[Clinical Cancer Research] The authors examine the efficacy of IRX4204, a highly specific rexinoid, in breast cancer cell lines and preclinical models to identify a biomarker for response and potential mechanism of action.

Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism

April 17, 2024

[Advanced Science] Using mechanically tuneable model systems, mimicking the range of stiffness's typically found within breast tumors, it was found that, contrary to expectations, cancer cells exposed to softer microenvironments were more able to colonize secondary tissues.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.