Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Linc00707 Regulates Autophagy and Promotes the Progression of Triple Negative Breast Cancer by Activation of PI3K/AKT/mTOR Pathway

[Cell Death Discovery] Linc00707 promoted TNBC cell proliferation, migration and invasion. Knockdown of Linc00707 influenced autophagy via PI3K/AKT/mTOR signaling pathway in TNBC cells.

Thermophoretic Glycan Profiling of Extracellular Vesicles for Triple-Negative Breast Cancer Management

[Nature Communications] Scientists reported that a lectin-based thermophoretic assay streamlined vibrating membrane filtration and thermophoretic amplification, allowing for rapid, sensitive, selective and cost-effective extracellular vesicle glycan profiling in TNBC plasma.

MCT4-Driven CAF-Mediated Metabolic Reprogramming in Breast Cancer Microenvironment Is a Vulnerability Targetable by miR-425-5p

[Cell Death Discovery] Investigators assessed the expression of miR-425-5p and its target monocarboxylate transporter (MCT4) in breast cancer associated fibroblasts (CAFs) and normal fibroblasts.

ACSL4-Mediated Membrane Phospholipid Remodeling Induces Integrin β1 Activation to Facilitate Triple-Negative Breast Cancer Metastasis

[Cancer Research] Investigators showed that metastatic TNBC tumors harbored more unsaturated phospholipids, especially long-chain polyunsaturated fatty acids, at the sn-2 position of phosphatidylcholine and phosphatidylethanolamine compared to primary tumors.

CARM1 Drives Triple-Negative Breast Cancer Progression by Coordinating with HIF1A

[Protein & Cell] The authors reported that coactivator-associated arginine methyltransferase 1 (CARM1) promoted proliferation, epithelial–mesenchymal transition, and stemness in TNBC.

PRMT5 Is an Actionable Therapeutic Target in CDK4/6 Inhibitor-Resistant ER+/RB-Deficient Breast Cancer

[Nature Communications] Through a genome-wide CRISPR screen, investigators identified protein arginine methyltransferase 5 (PRMT5) as a molecular vulnerability in ER+/RB1-knockout breast cancer cells.

Cell Morphology Best Predicts Tumorigenicity and Metastasis In Vivo across Multiple TNBC Cell Lines of Different Metastatic Potential

[Breast Cancer Research] Investigators sought to classify each breast cancer cell line as poorly or highly metastatic by characterizing tumor growth and metastasis in a murine model of six commonly used human triple-negative breast cancer xenografts, as well as determine which in vitro assays commonly used to study cell motility best predict in vivo metastasis.

MicroRNA-561-3p Indirectly Regulates the PD-L1 Expression by Targeting ZEB1, HIF1A, and MYC Genes in Breast Cancer

[Scientific Reports] Researchers investigated the inhibitory effect of microRNA-561-3p on ZEB1, HIF1A, and MYC expression as oncogenes that have the most impact on programmed death ligand 1 (PD-L1) overexpression and cellular processes such as proliferation, apoptosis, and cell cycle in breast cancer cell lines

Extracellular Vesicles Derived from SARS-CoV-2 M-Protein-Induced Triple Negative Breast Cancer Cells Promoted the Ability of Tissue Stem Cells Supporting Cancer Progression

[Frontiers In Oncology] The effects of M-protein on the ability of extracellular vesicles derived from triple-negative breast cancer cells to regulate the functions of tissue stem cells facilitating the tumor microenvironment were examined.

Aryl Hydrocarbon Receptor Suppresses STING-Mediated Type I IFN Expression in Triple-Negative Breast Cancer

[Scientific Reports] Using TNBC systems, investigators discovered the aryl hydrocarbon receptor suppressed type I interferon (IFN-I) expression via inhibition of STImulator of Interferon Genes (STING), a key mediator of interferon production.

USask Breast Cancer Research Targets Post-Treatment Function, Rehabilitation

[University of Saskatchewan College of Medicine] Dr. Angelica Lang's research project received $348,076 over four years from the Canadian Institutes of Health Research Project Grant program. Lang’s research explores relationships between types of surgeries and subsequent movement pattern alterations, as well as their implications for post-surgery rehabilitation.

Outlook and Opportunities for Engineered Environments of Breast Cancer Dormancy

[Science Advances] The authors address clinical and preclinical approaches to treating breast cancer dormancy, how precisely controlled artificial environments reveal key interactions that regulate breast cancer dormancy, and how future generations of biomaterials could answer further questions about breast cancer dormancy.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.

spot_img