SnoN Antagonizes the Hippo Kinase Complex to Promote TAZ Signaling during Breast Carcinogenesis
Investigators observed previously that the intracellular localization and expression levels of SnoNare sensitive to cell density, suggesting that it may crosstalk with Hippo signaling. Here they report that SnoN interacts with multiple components of the Hippo pathway to inhibit the binding of Lats2 to TAZ and the subsequent phosphorylation of TAZ, leading to TAZ stabilization. [Dev Cell] Abstract
Next-Generation Proteasome Inhibitor MLN9708 Sensitizes Breast Cancer Cells to Doxorubicin-Induced Apoptosis
Scientists used eight human breast cancer cell lines, which represent the major molecular subtypes of breast cancer, to validate the cytotoxic effects of MLN9708, alone and in combination with doxorubicin (Dox). They found that MLN9708 had cytotoxic effects, induced autophagy and MKP-1 expression, and enhanced Dox-induced apoptosis in these cell lines. [Sci Rep] Full Article
Bone Metastasis: The Importance of the Neighbourhood
The authors discuss the role of different bone cell types in supporting disseminated tumor cell dormancy and reactivation, and highlight the new opportunities this provides for targeting the bone microenvironment to control dormancy and bone metastasis. [Nat Rev Cancer] Abstract
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INDUSTRY NEWS
Miglioretti Awarded $7.5 Million to Evaluate Supplemental Breast Imaging
Diana Miglioretti, UC Davis dean’s professor of biostatistics and an internationally recognized breast cancer screening expert, has received $7.5 million to determine the effectiveness of two supplemental breast screening and diagnostic workup strategies – digital breast tomosynthesis and magnetic resonance imaging – used with mammography for cancer detection. [University of California, Davis] Press Release
Ikonopedia to Host First-Ever Web-Based Version of Tyrer-Cuzick Breast Cancer Risk Assessment Tool
Ikonopedia announced that it has reached an agreement to host the first-ever web-based version of the Tyrer-Cuzick Breast Cancer Risk Assessment Tool. The Tyrer-Cuzick Risk Assessment Tool is utilized to inform women about their lifetime risk of developing breast cancer and to help them make decisions about genetic testing and breast cancer screening options. [Ikonopedia] Press Release
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