Volume 8.18 | May 12

Mammary Cell News 8.18 May 12, 2016
Mammary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Scripps Florida Scientists Pioneer a Breakthrough Approach to Breast Cancer Treatment
Scientists have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers—triple negative breast cancer. [Press release from the Scripps Research Institute discussing online publication in Proceedings of the National Academy of Sciences] Press Release | Full Article
Culture and Characterize Human Mammary Epithelial Progenitors with Serum-Free EpiCult-B (Human) Free Protocols
 
PUBLICATIONS (Ranked by impact factor of the journal)
LABORATORY RESEARCH

Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism
To delineate the functional outcome of chromosome 8p loss of heterozygosity (LOH), a common aberration in breast cancer, scientists modeled 8p LOH using TALEN-based genomic engineering. [Cancer Cell] Full Article | Graphical Abstract

UM-164: A Potent c-Src/p38 Kinase Inhibitor with In Vivo Activity against Triple Negative Breast Cancer
Researchers hypothesized that binding the inactive kinase conformation would lead to improved pharmacological outcomes by altering the non-catalytic functions of the targeted kinases. [Clin Cancer Res] Abstract

MiR-16 Mediates Trastuzumab and Lapatinib Response in ErbB-2-Positive Breast and Gastric Cancer via Its Novel Targets CCNJ and FUBP1
Investigators revealed a novel mechanism underlying the antiproliferative effects of both agents in ErbB-2-positive breast cancer and gastric cancer. [Oncogene] Abstract

HOXA5 Determines Cell Fate Transition and Impedes Tumor Initiation and Progression in Breast Cancer through Regulation of E-Cadherin and CD24
The authors investigated cellular and molecular consequences of loss of HOXA5 in breast cancer, and the role played by retinoic acid in HOXA5 function. [Oncogene] Abstract

Identification of Selective Cytotoxic and Synthetic Lethal Drug Responses in Triple Negative Breast Cancer Cells
Scientists aimed to understand the functional differences of triple negative breast cancer (TNBC) subtypes and how they may relate to potential novel therapeutic strategies, they studied comprehensive anticancer-agent responses among a panel of TNBC cell lines. [Mol Cancer] Full Article

An Integrated Cell Line-Based Discovery Strategy Identified Follistatin and Kallikrein 6 as Serum Biomarker Candidates of Breast Carcinoma
Investigators compared the secretome of a series of four genetically-related breast cancer cell lines as a model of aggressiveness using quantitative mass spectrometry. 537 proteins predicted to be released or shed from cells were identified. [J Proteomics] Abstract

Breast Cancer Gene Therapy Using an Adenovirus Encoding Human IL-2 Under Control of Mammaglobin Promoter/Enhancer Sequences
Scientists have determined whether transcriptional targeting of interleukin-2 (IL-2) to breast cancer using an engineered human mammaglobin promoter/enhancer is a feasible option for reducing IL-2-associated toxicities while still achieving a meaningful antitumor effect. [Cancer Gene Ther] Abstract

CLINICAL RESEARCH

Two Years of Adjuvant Tamoxifen Provides a Survival Benefit Compared with No Systemic Treatment in Premenopausal Patients with Primary Breast Cancer: Long-Term Follow-Up (> 25 Years) of the Phase III SBII:2pre Trial
Researchers evaluated the long-term effect of two years of adjuvant tamoxifen compared with no systemic treatment (control) in premenopausal patients with breast cancer over different time periods through long-term follow-up. [J Clin Oncol] Full Article

TBCRC-010: Phase I/II Study of Dasatinib in Combination with Zoledronic Acid for the Treatment of Breast Cancer Bone Metastasis
The trial determined the recommended Phase II dose and clinical efficacy of the src-kinase inhibitor dasatinib combined with zoledronic acid in bone predominant, HER2-negative breast cancer metastases. [Clin Cancer Res] Abstract

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REVIEWS
Crosstalk between TGF-β Signaling and miRNAs in Breast Cancer Metastasis
The reviewers focus on the interaction between miRNAs and transforming growth factor-β (TGF-β) in breast cancer metastasis through modulating invasion-metastasis-related factors, including epithelial-to-mesenchymal transition, cancer stem cells, matrix metalloproteinase (MMP), tissue inhibitors of MMPs, cell adhesion molecules, and tumor microenvironment. [Tumour Biol] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.
 
INDUSTRY NEWS
Avelas Biosciences Announces Positive Interim Phase Ib Results and Advances to Dose Expansion Stage
Avelas Biosciences, Inc. announced positive interim results from a Phase Ib trial of its AVB-620 surgical marker in women with primary, non-recurrent breast cancer undergoing surgery. [Avelas Biosciences, Inc.] Press Release

Concure Oncology® Launches One-Time, One-Day Radiation Treatment for Early-Stage Breast Cancer
Concure Oncology/Breast Microseed, Inc. announces the launch of its one-time, one-hour radiation treatment option for early-stage breast cancer. Breast Microseed Treatment makes a quicker return to normal activity possible for post-lumpectomy patients by offering a simple, more convenient outpatient procedure. [Concure Oncology/Breast Microseed, Inc. (2016 PR Newswire Association LLC)] Press Release

Innocrin Pharmaceuticals, Inc. Begins Phase II Study of Seviteronel in Women with Estrogen Receptor-Positive or Triple-Negative Breast Cancer
Innocrin Pharmaceuticals, Inc. announced that they have started dosing in a Phase II study of women with estrogen receptor-positive or triple-negative breast cancer. The Phase I portion of the seviteronel study has completed and a once-daily dose was selected for advancement into Phase II development. [Innocrin Pharmaceuticals, Inc.] Press Release

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POLICY NEWS
Open-Access Index Delists Thousands of Journals
A leading index of open-access journals is set to shrink by more than one-quarter after delisting around 3,300 titles as part of an effort to exclude questionable and inactive publishers. [Nature News] Editorial

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Cancer Stem Cell Conference 2016
September 20-23, 2016
Cleveland, Ohio

Visit our events page to see a complete list of events in the mammary cell community.
 
JOB OPPORTUNITIES
NEW PhD Fellow – Small X-Ray Angle for Breast Cancer Diagnosis (CEA Tech)

NEW Postdoctoral Fellow(s) – Various Projects (National University of Singapore)

Research Technologist – Mammary and Prostate Stem Cell Biology (STEMCELL Technologies Inc.)

Research Associate – Cell Biology in Breast Cancer (University of South Australia)

Research Associate – Various Medical Disciplines (Jinan University)

Part-Time Researcher – Molecular Markers in Breast Cancer (University of Bergen)

Postdoctoral Fellow – RNA Splicing in Breast Cancer (Memorial Sloan Kettering Cancer Center)

Scientist – Cancer Research (Institute of Clinical Physiology)

Postdoctoral Fellow – Metastatic Reactivation of Cancer (MD Anderson Cancer Center)

Faculty Position – Cancer Immunology (University of New Mexico)

Faculty Position – Cancer Research (Eppley Institute for Research in Cancer)

Postdoctoral Fellow – Breast Cancer (Northwestern University)

Faculty Position – Tumor Immunology (John Wayne Cancer Institute at Providence Saint John’s Health Center)

Postdoctoral Fellow – Noncoding RNAs in Breast Cancer (University of Texas MD Anderson Cancer Center)

Postdoctoral Fellow – Breast and Ovarian Cancer (Johns Hopkins University School of Medicine)

Postdoctoral Fellowship – Platelets in Metastatic Breast and Colon Cancer (Université de Strasbourg)

Manager – Medical and Breast Imaging (Fred Hutchinson Cancer Research Center)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)


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