Gene Previously Observed Only in Brain Is Important Driver of Metastatic Breast Cancer
Scientists have shown that one gene that was once thought only to be found in the brain is also expressed in breast cancer and helps promote the growth and spread of the disease. Additionally, they showed how a version of the gene with edited RNA prevents metastasis. [Press release from The Wistar Institute discussing online prepublication in Nature Communications] Press Release|Full Article
Identification of Novel Pathways Linking Epithelial-to-Mesenchymal Transition with Resistance to HER2-Targeted Therapy
To identify pathways linked to resistance, investigators generated human epidermal growth factor receptor 2 (HER2)-positive breast cancer cell lines which are resistant to either lapatinib or AZD8931, two pan-HER family kinase inhibitors. Resistance was HER2 independent and was associated with epithelial-to-mesenchymal transition, resulting in increased proliferation and migration of the resistant cells. [Oncotarget] Full Article
ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer
Scientists presented the novel finding that conditioned medium derived from zinc finger E-box binding homeobox 1 (ZEB1)-expressing MDA-MB-231 cells significantly increased the capillary tube formation of human umbilical vein endothelial cells, whereas ZEB1 knockdown by RNA interference had the opposite effect. [PLoS One] Full Article
ELF5 and DOK7 Regulation in Anti-Estrogen Treated Cells and Tumors
Researchers characterized the expression of hormone receptors, and the mRNA and DNA methylation levels of docking protein 7 (DOK7), and E74-like factor 5 (ELF5), in 21 novel tamoxifen-resistant cell lines and extended the findings to primary and recurrent human breast tumors. [Cancer Cell Int] Full Article
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INDUSTRY NEWS
Breast Surgeon Yolanda R. Tammaro, M.D. Joins Ocean Medical Center, Meridian Cancer Care
Ocean Medical Center has expanded women’s health and breast cancer surgical programs with the recruitment of Yolanda R. Tammaro, M.D. Dr. Tammaro is fellowship trained and board certified in Breast Surgical Oncology, providing the team at Ocean Medical Center and Meridian Cancer Care with additional expertise and resources for local community members. [Ocean Medical Center] Press Release
Seven Bridges Goes Live with Cancer Genomics Cloud Pilot
Seven Bridges announced that its system was selected to develop as part of the National Cancer Institute’s Cloud pilot program is open to researchers worldwide. The Seven Bridges Cancer Genomics Cloud is the first complete ecosystem to give cancer researchers immediate access to one of the world’s largest genomic datasets — The Cancer Genome Atlas — and the computational resources to analyze it. [Seven Bridges] Press Release
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