Stem and Progenitor Cell Division Kinetics during Postnatal Mouse Mammary Gland Development
The cycling properties of mammary stem and progenitor cells is not well understood. To determine the division properties of these cells, researchers administered synthetic nucleosides for varying periods of time to mice at different stages of postnatal development and monitored the rate of uptake of these nucleosides in the different mammary cell compartments. [Nat Commun] Full Article
Breast Cancer Cell Adhesome and Degradome Interact to Drive Metastasis
The authors compared non-metastatic and metastatic human breast cancer cell lines and xenografts, in which they measured growth rate, migration, invasion, colony formation, protein expression, and enzyme activity in vitro and in vivo. [npj Breast Cancer] Full Article
Advances in Small-Molecule Drug Discovery for Triple-Negative Breast Cancer
The authors highlight recent therapeutic advances in triple-negative breast cancer, focusing on small-molecule drugs and their associated biological mechanisms of action, and offering the possibility of improved prospects for this patient group in the near future. [Future Med Chem] Abstract
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