Volume 7.40 | Oct 15

Mammary Cell News 7.40 October 15, 2015
Mammary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Breast Cancer Genomic Analysis Reveals Invasive Lobular Carcinoma Subtypes
Researchers have revealed new subtypes of invasive lobular carcinoma, the second most commonly diagnosed invasive breast cancer type. [Press release from University of North Carolina Health Care System (Newswise, Inc.) discussing publication in Cell] Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
LABORATORY RESEARCH

An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis
Investigators found that an epigenetic pathway involving MLL2 is crucial for growth of human epidermal growth factor receptor 2 (HER2)+ cells and MLL2 reduces sensitivity of the cancer cells to a HER2 inhibitor, lapatinib. [Cancer Cell] Abstract | Press Release

PDK1 Promotes Tumor Growth and Metastasis in a Spontaneous Breast Cancer Model
Investigators revealed that mammary-specific ablation of phosphoinositide-dependent kinase 1 (PDK1) could delay tumor initiation, progression and metastasis in a spontaneous mouse tumor model. [Oncogene] Abstract

ASCT2/SLC1A5 Controls Glutamine Uptake and Tumor Growth in Triple-Negative Basal-Like Breast Cancer
Pharmacological inhibitors of alanine, serine, cysteine-preferring transporter 2 (ASCT2; SLC1A5)-mediated transport significantly reduced glutamine uptake in human breast cancer cell lines, leading to the suppression of mTORC1 signaling, cell growth and cell cycle progression. [Oncogene] Full Article

Distinct Microbiological Signatures Associated with Triple Negative Breast Cancer
Researchers utilized a pan-pathogen array technology to identify the microbial signatures associated with triple negative breast cancer (TNBC). The results, validated by PCR and sequencing, defined a microbial signature present in TNBC tissue which was underrepresented in normal tissue. [Sci Rep] Full Article | Press Release

CA1 Contributes to Microcalcification and Tumorigenesis in Breast Cancer
Scientists aimed to determine whether carbonic anhydrase I (CA1) was correlated with microcalcification and with other processes that are involved in breast cancer tumorigenesis. Acetazolamide, a chemical inhibitor of CA1, was also added to the culture to determine the role of CA1 in calcification. [BMC Cancer] Full Article

Strategy of STAT3β Cell-Specific Expression in Macrophages Exhibits Antitumor Effects on Mouse Breast Cancer
Researchers showed that STAT3β gene under the control of CD68 macrophage-specific promoter was only expressed in macrophages, which significantly inhibited the motility and invasion of breast cancer cells when co-cultured with 4T1 cells [Gene Ther] Abstract

CLINICAL RESEARCH

Paclitaxel, Bevacizumab, and Everolimus/Placebo as First-Line Treatment for Patients with Metastatic HER2-Negative Breast Cancer: A Randomized Placebo-Controlled Phase II Trial of the Sarah Cannon Research Institute
This randomized Phase II trial compared the efficacy of paclitaxel/bevacizumab/everolimus and paclitaxel/bevacizumab/placebo as first-line treatment for metastatic breast cancer. [Breast Cancer Res Treat] Abstract

Tumor Biology, Metastatic Sites and Taxanes Sensitivity as Determinants of Eribulin Mesylate Efficacy in Breast Cancer: Results from the ERIBEX Retrospective, International, Multicenter Study
Investigators aimed at evaluating the activity and safety of eribulin mesylate in pretreated metastatic breast cancer in a routine clinical setting. Tumor response was assessed every three cycles of treatment. [BMC Cancer] Full Article

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REVIEWS
Natural and Therapy-Induced Immunosurveillance in Breast Cancer
The authors point out that the successful implementation of immunotherapy to breast cancer management requires the optimization of current immunotherapeutic regimens and the identification of immunological biomarkers that enable improved risk stratification and the design of personalized, dynamic treatment plans. [Nat Med] Abstract

Visit our reviews page to see a complete list of reviews in the Mammary Cell research field.
 
INDUSTRY NEWS
Cancer Research UK Launches £100 Million Grand Challenges to Tackle the Most Important Questions in Cancer
Cancer Research UK has launched Grand Challenges – the biggest and most ambitious cancer grants in the world – which aim to overcome the greatest barriers standing in the way of beating cancer. The £100 million investment will revolutionize how researchers diagnose, prevent and treat cancer by uniting teams of the best scientists around the world to come up with answers to crucial questions about how to save more lives from cancer. [Cancer Research UK] Press Release

$4.15 Million Grant Explores How Diet and Sunscreen May Increase Breast Cancer Risk
Two Michigan State University researchers have been awarded a five-year, $4.15 million grant to examine how a high-fat diet interacts with a common chemical found in sunscreen and what effect it has on breast cancer risk. [Michigan State University] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW Stem Cells: Development & Management
November 30-December 2, 2015
Phitsanulok, Thailand

Visit our events page to see a complete list of events in the Mammary Cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Fellow – Metastatic Breast Cancer (Purdue University Center for Cancer Research)

Scientific Officer – Molecular Cell Biology (Institute of Cancer Research)

Biological Imaging Scientist – 3D Cellular Models of Organs and Disease (University of Pittsburgh Drug Discovery Institute)

Postdoctoral Fellow – Cancer Biology (The Francis Crick Institute)

Postdoctoral Fellow – Tumor Dormancy (Fred Hutchinson Cancer Research Center)

Postdoctoral Research Scientist – Breast Cancer (Cancer Research UK Beatson Institute)

Postdoctoral Fellow – Breast Cancer Research (University Health Network)

Research Scientist – Epithelial Stem Cells (A*STAR)

Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Postdoctoral Fellowship – Cancer Biology (Massachusetts General Hospital Cancer Center/Harvard Medical School)

Postdoctoral Research Fellow – Metastatic Breast Cancer (Fred Hutchinson Cancer Research Center)


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