Mammary Cell News

Mammary Cell News is an online resource covering the latest research into breast cancer and mammary cells.

Coordinated Activation of DNMT3a and TET2 in Cancer Stem Cell-Like Cells Initiates and Sustains Drug Resistance in Hepatocellular Carcinoma

[Cancer Cell International] Scientists addressed whether and how dysregulated epigenetic regulators have regulatory and functional communications in establishing and maintaining drug resistance.

Endocytic Activation and Exosomal Secretion of Matriptase Stimulate the Second Wave of EGF Signaling to Promote Skin and Breast Cancer Invasion

[Cell Reports] Investigators demonstrated a vesicular-trafficking-mediated interplay between matriptase and epidermal growth factor (EGF) signaling in skin and breast cancer promotion. EGF induced matriptase to undergo endocytosis together with the EGF receptor, followed by acid-induced activation in endosomes.

UT Tyler Fisch College of Pharmacy Awarded NIH Grant

[The University of Texas at Tyler] The University of Texas at Tyler received a $447,195 grant from the National Institutes of Health to support the research of Dr. May Abdelaziz, Ben and Maytee Fisch College of Pharmacy assistant professor, in HER2, a protein that promotes the growth of breast cancer.

Long-Term Multimodal Recording Reveals Epigenetic Adaptation Routes in Dormant Breast Cancer Cells

[Cancer Discovery] The authors investigated genetic and transcriptional changes underlying tumor awakening, and it was demonstrated that endocrine therapies induced nongenetic cell state transitions into dormancy in a stochastic subset of cells via epigenetic reprogramming.

Establishment of Patient-Derived Organoids for Guiding Personalized Therapies in Breast Cancer Patients

[International Journal Of Cancer] Scientists established 75 patient-derived breast cancer organoid models. The results of H&E staining, immunohistochemical, and whole-exome sequencing revealed that patient-derived organoids inherited the histologic and genetic characteristics of their parental tumor tissues.

Mechanosensitive TRPV4 Channel Guides Maturation and Organization of the Bilayered Mammary Epithelium

[Scientific Reports] Investigators reported that transient receptor potential cation channel subfamily V member (TRPV4) was prominently expressed in the stem/progenitor cell populations of the mammary epithelium, and seemed important for the lineage-specific differentiation, consequently affecting mechanical features of the mature mammary epithelium.

Stress in the Metastatic Journey – The Role of Cell Communication and Clustering in Breast Cancer Progression and Treatment Resistance Icon for the Forest...

[Disease Models & Mechanisms] The authors delve into the intrinsic stresses that cancer cells encounter throughout the metastatic journey and the additional stresses induced by therapeutic interventions. Scientists focus on elucidating the strategies adopted by cancer cells, such as cell–cell clustering and intricate cell–cell communication mechanisms, to ensure their survival.

Springer Nature and the Breast Cancer Research Foundation Announce the Rising Scholars: Breast Cancer Program for Early Career Researchers

[Springer Nature] Springer Nature and the Breast Cancer Research Foundation (BCRF) announced the Rising Scholars: Breast Cancer program, a partnership between Nature Portfolio and BCRF which provides early career researchers in the field of cancer with additional resources for professional development and career preparedness.

ProLynx Announces Initiation of the Phase II Topology Clinical Trial of Its DNA-Damaging Agent PLX038 in Triple-Negative Breast Cancer at the Institut Curie

[ProLynx, Inc. (BioSpace)] ProLynx, Inc. announced that the first patient was included in Topology by investigator Dr. Delphine Loirat, with a Phase II clinical trial investigating PLX038 for locally-advanced or metastatic TNBC.

Ropivacaine as a Novel AKT1 Specific Inhibitor Regulates the Stemness of Breast Cancer

[Journal of Experimental & Clinical Cancer Research] The effects of ropivacaine on breast cancer stemness were investigated by in vitro and in vivo assays. The authors reported that ropivacaine suppressed stem cell-like properties of breast cancer cells.

miR-218-5p and Doxorubicin Combination Enhances Anticancer Activity in Breast Cancer Cells through Parkin-Dependent Mitophagy Inhibition

[Cell Death Discovery] Investigators analyzed the role of mitophagy in the treatment of the most common anticancer drug, doxorubicin, in different models of breast cancer.

A Subpopulation of Luminal Progenitors Secretes Pleiotrophin To Promote Angiogenesis and Metastasis in Inflammatory Breast Cancer

[Cancer Research] Using single-cell RNA sequencing, multiplex staining, and serum analysis in inflammatory breast cancer (IBC) patients, scientists identified enrichment of a subgroup of luminal progenitor cells containing high expression of the neurotropic cytokine pleiotrophin in IBC tumors.

For over a decade, Mammary Cell News has been keeping the global scientific and medical communities informed about the latest research, reviews, and news in the field of mammary tissues. Our editors gather publications on the topic of mammary cell differentiation and characterization, as well as the progression and treatment of breast cancer. We also keep scientists up-to-date on the latest policy changes, job postings, and events.

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