Volume 7.20 | May 28

Mammary Cell News 7.20 May 28, 2015
Mammary Cell News
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Scientists Identify Key to Preventing Secondary Cancers
Scientists have identified a possible key to preventing secondary cancers in breast cancer patients, after discovering an enzyme which enhances the spread of the disease. They found that the enzyme lysYl oxidase released from the primary tumor causes holes in bone and prepares the bone for the future arrival of cancer cells. [Press release from the University of Sheffield discussing online prepublication in Nature]
Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Upregulation of ER Signaling as an Adaptive Mechanism of Cell Survival in HER2-Positive Breast Tumors Treated with Anti-HER2 Therapy
Researchers investigated the direct effect and therapeutic consequences of epidermal growth factor receptor 2 (HER2)-targeting therapy on expression of estrogen receptor (ER) and Bcl2 in preclinical models and clinical tumor samples. [Clin Cancer Res] Abstract

Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions
Scientists identified E-cadherin as a surface antigen able to reproducibly enrich for tumor-initiating cells in well annotated, low passage triple-negative breast cancer and ovarian cancer patient-derived xenografts. [Clin Cancer Res] Abstract | Full Article

HER2-mTOR Signaling-Driven Breast Cancer Cells Require ER-Associated Degradation to Survive
Genetic ablation or pharmacological inhibition of endoplasmic reticulum (ER)-associated degradation (ERAD) led to irrecoverable endoplasmic reticulum stress and selectively killed human epidermal growth factor 2 (HER2+) breast cancer cells. Cell death caused by ERAD inhibition partially depended on increased HER2-mTOR signaling, which imposed an increased proteotoxic burden on the ER. [Sci Signal] Abstract

MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor
The authors identified breast cancer cell lines that depend upon MCL-1 for survival and subsequently determined the mechanism of apoptosis mediated by the MCL-1 selective inhibitor A-1210477. They demonstrated that apoptosis resulting from a loss in MCL-1 function requires expression of the pro-apoptotic protein BAK. [Mol Cancer Ther] Abstract

Curcumin Inhibits PhIP Induced Cytotoxicity in Breast Epithelial Cells through Multiple Molecular Targets
Researchers demonstrated the mechanisms by which curcumin inhibits amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced cytotoxicity in normal breast epithelial cells. [Cancer Lett] Abstract

Targeting ADAM-17 with an Inhibitory Monoclonal Antibody Has Antitumor Effects in Triple-Negative Breast Cancer Cells
Researchers investigated the antitumor effects of a monoclonal antibody against ADAM-17 on an in vitro model of triple negative breast cancer. [Br J Cancer] Abstract

IRF-1 Inhibits NF-κB Activity, Suppresses TRAF2 and cIAP1 and Induces Breast Cancer Cell Specific Growth Inhibition
Investigators initiated studies comparing the effect of interferon regulatory factor (IRF)-1 in human nonmalignant breast cell and breast cancer cell lines. While IRF-1 in breast cancer cells results in growth inhibition and cell death, profound growth inhibition and cell death are not observed in nonmalignant human breast cells. [Cancer Biol Ther] Abstract

Requirement of ERα and Basal Activities of EGFR and Src Kinase in Cd-Induced Activation of MAP/ERK Pathway in Human Breast Cancer MCF-7 Cells
The role of cell surface receptors ERα, EGFR, and Src kinase was evaluated in human breast cancer MCF-7 cells treated with 1–3 μM cadmium(Cd). [Toxicol Appl Pharmacol] Abstract | Graphical Abstract

53BP1 Suppresses Epithelial-Mesenchymal Transition by Down-Regulating ZEB1 through miR-200b/429 in Breast Cancer
Scientists demonstrated that 53BP1 negatively regulated the epithelial-mesenchymal transition by modulating ZEB1 through targeting miR-200b and miR-429. Furthermore, 53BP1 promoted ZEB1-mediated up-regulation of E-cadherin and also inhibited the expressions of mesenchymal markers, leading to increased migration and invasion in MDA-MB-231 breast cancer cells. [Cancer Sci] Abstract


Phase II Neoadjuvant Clinical Trial of Carboplatin and Eribulin in Women with Triple Negative Early-Stage Breast Cancer (NCT01372579)
Investigators evaluated the efficacy and safety of neoadjuvant treatment with carboplatin and eribulin in patients with early-stage triple negative breast cancer, and explored biomarkers based on DNA and protein expression profiles as predictors of response. [Breast Cancer Res Treat] Abstract

Pegylated Liposomal Doxorubicin (Lipo-Dox®) Combined with Cyclophosphamide and 5-Fluorouracil Is Effective and Safe as Salvage Chemotherapy in Taxane-Treated Metastatic Breast Cancer: An Open-Label, Multi-Center, Non-Comparative Phase II Study
Researchers evaluated the efficacy and safety of Lipo-Dox® used as part of a combination salvage therapy for patients with metastatic breast cancer whose tumors progressed during or after taxane-based treatment. [BMC Cancer] Full Article

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Retinoids Induce Cellular Senescence in Breast Cancer Cells by RAR-β Dependent and Independent Pathways: Potential Clinical Implications
The authors discuss the role of retinoic acid receptors β2 and 5 (RARβ2 and RARβ5) and of receptor independent genes involved in mediating the senescence program of retinoids and rexinoids in ER+ and ER breast cancer cells. [Int J Oncol] Abstract

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Pfizer Announces $3 Million Grants Program to Further Clinical Research in Advanced Breast Cancer
Pfizer Inc. announced the launch of a competitive, peer-reviewed grants program to support clinical research projects investigating IBRANCE® (palbociclib) in advanced breast cancer. [Pfizer Inc.] Press Release

CPRIT Awards $16.6 Million for Cancer Research, Prevention, and Faculty Recruitment
The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded UT Southwestern Medical Center researchers more than $12.6 million in research grants for cancer research and prevention, as well as an additional $4 million for recruiting cancer scientists. [UT Southwestern Medical Center] Press Release

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NEW Cell Symposia Meeting – Stem Cell Epigenetics
September 20-22, 2015
Sitges, Spain

Visit our events page to see a complete list of events in the mammary cell community.
NEW Assistant/Associate/Full Professor – Oncology (Shanghai Jiao Tong University School of Medicine)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Research Assistant – Role of BRCA1 in the Repair of DNA Damage (University of Dundee)

Postdoctoral Position – Malignant Breast Cancer Cells in the Bone Marrow Microenvironment (Duke University)

Postdoctoral Position – Fatty Acid Metabolism Inhibition on Chemoresistant TNBC Models (University of Girona)

Postdoctoral Fellow – Regulation of Growth and Survival of Breast Cancer Cells (Icahn School of Medicine at Mount Sinai)

Postdoctoral Technician – Prostate/Breast Cancer (Baylor College of Medicine)

Postdoctoral Research Fellow/Instructor – Prostate/Breast Cancer (Baylor College of Medicine)

Postdoctoral Positions – Molecular Cancer Biology (University of Pennsylvania)

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