TSRI Researchers Connect Haywire Protein to Breast Cancer, Leukemia
A new study sheds light on the cause of some cancers, including breast cancer and leukemia. Researchers found that too much of a key protein, called cyclin E, slows down DNA replication and introduces potentially harmful cancer-linked mutations when cells divide. [Press release from The Scripps Research Institute (TSRI) discussing online publication in Current Biology] Press Release|Abstract
ErbB2-Intronic MicroRNA-4728: A Novel Tumor Suppressor and Antagonist of Oncogenic MAPK Signaling
Investigators demonstrated that microRNA-4728 is a negative regulator of mitogen-activated protein kinase (MAPK) signaling through directly targeting the extracellular-signal related kinase upstream kinase mammalian STE20-like protein kinase 4 and exerted numerous tumor-suppressive properties in vitro and in animal models. [Cell Death Dis] Full Article
Metastatic Breast Cancer Cells in Lymph Nodes Increase Nodal Collagen Density
Scientists investigated extracellular matrix molecules such as collagen I fibers in the lymph nodes of mice bearing orthotopic human breast cancer xenografts. The lymph nodes in mice with metastatic MDA-MB-231 and SUM159 tumor xenografts and tumor xenografts grown from circulating tumor cell lines displayed an increased collagen I density compared to mice with no tumor and mice with non-metastatic T-47D and MCF-7 tumor xenografts. [Sci Rep] Full Article
Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells
The authors found that the levels of integrin β4 (ITG β4) palmitoylation correlated with the invasive potential of breast cancer cells, and that curcumin effectively reduced the levels of ITG β4 palmitoylation in invasive breast cancer cells. [PLoS One] Full Article
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INDUSTRY NEWS
New Anti-Cancer Stem Cell Compound in Development
Scientists have developed a novel anti-cancer stem cell agent capable of targeting aggressive tumor forming cells common to breast, pancreas, colon and prostate cancers. The new OH14 compound has been licensed by Tiziana Life Sciences, a British-based pharmaceutical company. [Cardiff University] Press Release
Genetic Mapping for Breast Cancer Risk
The Medical College of Wisconsin has received a five-year, $1.75 million dollar grant from the National Institutes of Health’s National Cancer Institute to identify factors in the microenvironment of tumors that impact breast cancer risk. [Medical College of Wisconsin] Press Release
UB Spinoff Gets $2 Million for Research on Cancer Therapy
For-Robin, a University at Buffalo (UB) spinoff company, has received a $2 million grant from the National Cancer Institute to study and develop a promising potential treatment for breast and other types of cancer, UB and U.S. Congressman Brian Higgins have announced. [University of Buffalo] Press Release
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