Researchers Identify New Ways to Drain Cancer’s ‘Fuel Tank’
By observing cancer stem cells in a lab setting, researchers discovered that mitochondria are especially important for the proliferative expansion and survival of cancer stem cells, also known as ‘tumor initiating cells’, which would then promote treatment resistance. The research was carried out in breast cancer stem cells grown in a lab, but the theory was also checked against human breast cancer cells from patients. [Research from the University of Manchester discussing publication in Oncotarget] Press Release|Full Article
A Positive Role of DBC1 in PEA3-Mediated Progression of Estrogen Receptor-Negative Breast Cancer
Scientists report that deleted in breast cancer 1 (DBC1) functions as a coactivator for the oncogenic ETS transcription factor PEA3 to promote estrogen receptor (ER)-negative breast cancer progression. DBC1 depletion inhibited the tumorigenic properties of ER-negative breast cancer cells in vitro and in vivo. [Oncogene] Abstract
Invasive Breast Carcinoma Cells from Patients Exhibit MenaINV– and Macrophage-Dependent Transendothelial Migration
Scientists found that intravasation of breast cancer cells may be prevented by blocking the signaling between cancer cells and macrophages. They obtained invasive breast ductal carcinoma cells of various subtypes by fine-needle aspiration biopsies from patients and found that, in an in vitro transendothelial migration assay, cells that migrated through a layer of human endothelial cells were enriched for the transcript encoding MenaINV. [Sci Signal] Abstract|Press Release
Inhibition of SGK1 Enhances mAR-Induced Apoptosis in MCF-7 Breast Cancer Cells
Testosterone albumin conjugates (TAC)-stimulated membrane androgen receptors (mAR) activation elicited apoptosis of MCF-7 cells, an effect significantly potentiated by concomitant incubation of the cells with TAC and the specific SGK1 inhibitors EMD638683 and GSK650394. [Cancer Biol Ther] Abstract
Animal Models for Exploring the Pharmacokinetics of Breast Cancer Therapies
This review focuses on transgenic, xenograft, and syngeneic murine breast cancer models, the ectopic, orthotopic and intravenous methods of cell implantation, and the ethics of animal experimentation. It also includes the latest data on tumor gene expression and the issues to consider when exploring the pharmacokinetics and efficacy of breast cancer therapies. [Expert Opin Drug Metab Toxicol] Abstract
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