Volume 6.42 | Oct 30

Mammary Cell News 6.42 October 30, 2014
Mammary Cell News
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How Stromal Cells Influence Therapy Resistance in Breast Cancer
Stromal cells communicate with breast cancer cells using exosomes containing RNA. The RNA can activate genetic pathways in breast cancer cells that make them therapy resistant. [Press release from the Netherlands Cancer Institute discussing publication in Cell] Press Release | Abstract | Graphical Abstract
Culture and Characterize Human Mammary Epithelial Progenitors with Serum-Free EpiCult-B (Human) Free Protocols
PUBLICATIONS (Ranked by impact factor of the journal)

ASPP2 Controls Epithelial Plasticity and Inhibits Metastasis through ​β-Catenin-Dependent Regulation of ​ZEB1
Scientists identified ​ASPP2, a haploinsufficient tumor suppressor, ​p53 activator and ​PAR3 binding partner, as a molecular switch of mesenchymal to epithelial transition and epithelial to mesenchymal transition. ​
[Nat Cell Biol]
Abstract | Press Release

Hypoxia Promotes Stem Cell Phenotypes and Poor Prognosis through Epigenetic Regulation of ​DICER
Researchers identified tumor hypoxia as a regulator of ​DICER expression in large cohorts of breast cancer patients. Reduced microRNA processing leads to derepression of the miR-200 target ​ZEB1, stimulates the epithelial to mesenchymal transition and ultimately results in the acquisition of stem cell phenotypes in human mammary epithelial cells. [Nat Commun] Abstract | Press Release

Cytokeratin19 Induced by HER2/ERK Binds and Stabilizes HER2 on Cell Membranes
Using an LC-MS/MS proteomics approach, investigators found that cytokeratin19 (KRT19) was upregulated in HER2-overexpressing cells and tissues. KRT19 phosphorylated by Akt could bind HER2 on the plasma membrane and stabilized HER2 via inhibition of proteasome-mediated degradation of HER2. [Cell Death Differ] Abstract

MYC Regulates the Unfolded Protein Response and Glucose and Glutamine Uptake in Endocrine Resistant Breast Cancer
Scientists identified MYC, an oncoprotein that is upregulated in endocrine resistant breast cancer, as a regulator of the unfolded protein response in glucose-deprived conditions. ER+ human breast cancer cell lines and rat mammary tumors were used to confirm upregulation of MYC in endocrine resistance. [Mol Cancer] Full Article

Human Breast Progenitor Cell Numbers Are Regulated by WNT and TBX3
Researchers identified two phenotypically distinguishable lineage-committed progenitor cells that contribute to different structural elements and are regulated via hormonal and non-hormonal mechanisms. WNT signaling regulates both types of progenitor activity. [PLoS One] Full Article

Elevated CXCL1 Expression in Breast Cancer Stroma Predicts Poor Prognosis and Is Inversely Associated with Expression of TGF-Beta Signaling Proteins
Researchers sought to characterize the expression patterns of CXCL1 in breast cancer stroma, determine the prognostic significance of stromal CXCL1 expression, and identify factors affecting stromal CXCL1 expression. [BMC Cancer] Abstract | Full Article

Bmi1 Regulates Self-Renewal and Epithelial to Mesenchymal Transition in Breast Cancer Cells through Nanog
Scientists explored the role of Bmi1 in regulating the stemness and drug resistance of breast cancer cells. Bmi1 overexpression in immortalized and transformed breast epithelial cells increased their sphere-forming efficiency, induced epithelial to mesenchymal transition with an increase in the expression of stemness-related genes. [BMC Cancer] Abstract | Full Article


Biomarker Analyses in CLEOPATRA: A Phase III, Placebo-Controlled Study of Pertuzumab in Human Epidermal Growth Factor Receptor 2-Positive, First-Line Metastatic Breast Cancer
Investigators explored the prognostic and/or predictive value of human epidermal growth factor receptor 2 (HER2) pathway-related biomarkers in the Phase III study of pertuzumab plus trastuzumab plus docetaxel versus placebo plus trastuzumab plus docetaxel as first-line treatment for patients with HER2-positive metastatic breast cancer. [J Clin Oncol] Abstract

Phase III Study of Iniparib Plus Gemcitabine and Carboplatin Versus Gemcitabine and Carboplatin in Patients With Metastatic Triple-Negative Breast Cancer
A randomized Phase II trial showed significant benefit for gemcitabine, carboplatin, and iniparib over gemcitabine and carboplatin in clinical benefit rate, response rate, progression-free survival, and overall survival. Scientists formally compared the efficacy of these regimens in a Phase III trial. [J Clin Oncol] Abstract

Learn to Enumerate Mammospheres & Tumorspheres Cultured in MammoCult: Watch Procedure Now
DNA Methylome Profiling beyond Promoters: Taking an Epigenetic Snapshot of the Breast Tumor Microenvironment
The authors review the role of DNA methylation in breast cancer and cell lineage specification as well as inform about the composition and clinical relevance of the tumor microenvironment. [FEBS J] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the mammary cell research field.
NRC and AvidBiologics Progress New Treatments to Seek and Destroy Cancer Cells
AvidBiologics Inc. and the National Research Council of Canada (NRC) are collaborating on one of the most promising advances in the fight against cancer: antibody-drug conjugates (ADCs). Recently signed research and licensing agreements will enable both organizations to continue developing a series of ADCs targeting breast, lung, and head-and-neck cancers. [National Research Council of Canada] Press Release

Bristol-Myers Squibb Enters into Agreement that Provides an Exclusive Option to Acquire F-star Alpha Ltd. and Its Novel HER2-Targeted Therapy
Bristol-Myers Squibb Company and F-star Alpha Ltd. have entered into an agreement that provides Bristol-Myers Squibb the exclusive option to acquire F-star Alpha Ltd. and gain worldwide rights to its lead asset FS102. FS102 is a novel Phase I ready human epidermal growth factor receptor 2 (HER2)-targeted therapy in development for the treatment of breast and gastric cancer among a well-defined population of HER2-positive patients who do not respond or become resistant to current therapies. [Bristol-Myers Squibb Company] Press Release

Compugen Discloses Successful Validation Results for Novel B7/CD28-Like Cancer Immunotherapy Target Candidate
Compugen Ltd. disclosed successful experimental data for CGEN-15027, a Compugen-discovered immune checkpoint target candidate. The experimental results include its expression in the cancer microenvironment, both on cancer cells derived from lung, breast, and liver cancer patients, and on tumor infiltrating immune cells. [Compugen Ltd.] Press Release

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW 5th International Conference on Stem Cells and Cancer (ICSCC-2014): Proliferation, Differentiation and Apoptosis
November 8-10, 2014
New Delhi, India

NEW 2014 Pathology Congress
December 2-4, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the mammary cell community.
NEW Postdoctoral Position – Cancer Metabolism (New York University Langone Medical Center)

NEW Postdoctoral Position – Protein-Protein Interactions in Leukemia and Breast Cancer (University of Dundee)

PhD Position – Protein Interactions in Cancer Regulation (University of East Anglia)

Postdoctoral Position – Novel DNA Damage Checkpoint Pathways and Variants in Potential Breast Cancer Genes (University of Copenhagen)

Postdoctoral Fellow – Breast Cancer (University of Texas Health Science Center at San Antonio)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

Postdoctoral Position – Breast Cancer Biology (UT Southwestern)

Postdoctoral Fellow – Breast Cancer Research (The University of Texas MD Anderson Cancer Center)

Postdoctoral Fellow – Stem Cells and Breast Cancer (Albert Einstein College of Medicine)

Postdoctoral Fellow – Breast Cancer Translational Research (University of Houston – College of Pharmacy)

Scientist – Mammary Cell Research (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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