Role of Erbin in ErbB2-Dependent Breast Tumor Growth
Scientists report that Erbin, a v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ErbB2)-interacting protein that was thought to act as an antitumor factor, is specifically expressed in mammary luminal epithelial cells and facilitates ErbB2-dependent proliferation of breast cancer cells and tumorigenesis in MMTV-neu transgenic mice. [Proc Natl Acad Sci USA] Abstract
Generation of MCF-7 Cells with Aggressive Metastatic Potential In Vitro and In Vivo
Scientists generated “aggressive” MCF-7 breast cancer cells, which show significantly increased invasion in contrast to wild type MCF-7 cells. In addition, they analyzed whether these cell lines differ in their metastatic behavior in vivo and in expression of invasion and/or epithelial-mesenchymal transition-relevant genes. [Breast Cancer Res Treat] Abstract
Obesity, Proinflammatory Mediators, Adipose Tissue Progenitors, and Breast Cancer
The authors discuss the role of white adipose tissue (WAT) cells and of related soluble factors in the local and metastatic growth of this neoplastic disease. Moreover, they discuss the recent increase in the use of WAT-derived progenitor cells in breast cancer patients to enhance the quality of breast reconstruction and the related risks. [Curr Opin Oncol] Abstract
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