Volume 6.34 | Sep 4

Mammary Cell News 6.34 September 4, 2014
Mammary Cell News
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Mammary Stem Cells Have Myoepithelial Cell Properties
Researchers observed that up to 54% of single basal cells can form colonies when seeded into adherent culture in the presence of agents that disrupt actin-myosin interactions, and on average, 65% of the single-cell-derived basal colonies can repopulate a mammary gland when transplanted in vivo. [Nat Cell Biol] Abstract
Culture and Characterize Human Mammary Epithelial Progenitors with Serum-Free EpiCult-B (Human) - Free Protocols
PUBLICATIONS (Ranked by impact factor of the journal)

The Chemokine Receptor CXCR7 Interacts with EGFR to Promote Breast Cancer Cell Proliferation
Researchers examined the pattern of CXCR7 expression and its role in regulation of growth signaling in breast cancer. CXCR7 was expressed in both, estrogen receptor positive and negative breast cancer cell lines. [Mol Cancer] Abstract | Full Article

AR Collaborates with ERα in Aromatase Inhibitor-Resistant Breast Cancer
Researchers engineered estrogen receptor (ER)-positive MCF-7 cells to overexpress aromatase and androgen receptor (AR) to explore the role of AR in aromatase inhibitor resistance. [Breast Cancer Res Treat] Abstract

Increased Androgen Receptor Activity and Cell Proliferation in Aromatase Inhibitor-Resistant Breast Carcinoma
The purpose of this study was to examine the potential correlation between the androgen receptor- and aromatase inhibitors (AI)-resistant breast carcinoma. Scientists performed immunohistochemical analysis of 21 pairs of primary breast carcinoma and corresponding AI-resistant recurrent tissue samples and established two stable variant cell lines from ER-positive T-47D breast carcinoma cell line as AI-resistance models and used them in in vitro experiments. [J Steroid Biochem Mol Biol] Abstract

NF-κB Affects Proliferation and Invasiveness of Breast Cancer Cells by Regulating CD44 Expression
Researchers analyzed the role of NF-κB in regulating CD44 expression in triple negative breast cancer cells, MDA-MB-231 and SUM159. Inhibition of NF-κB by Bay-11-7082 resulted in a reduction in CD44 expression. [PLoS One] Full Article

Chlorpyrifos Inhibits Cell Proliferation through ERK1/2 Phosphorylation in Breast Cancer Cell Lines
Scientists aimed to identify the pathway involved in chlorpyrifos-inhibited cell proliferation in MCF-7 and MDA-MB-231 breast cancer cell lines. [Chemosphere] Abstract

Estrogen Increases Nrf2 Activity through Activation of the PI3K Pathway in MCF-7 Breast Cancer Cells
Researchers report that estrogen increases nuclear factor erythroid 2-related factor (Nrf2) activity in MCF7 breast cancer cells through activation of the phosphatidylinositol 3-kinase (PI3K)/glycogen synthase kinase 3 beta pathway. [Exp Cell Res] Abstract

SLIT/ROBO2 Signaling Promotes Mammary Stem Cell Senescence by Inhibiting Wnt Signaling
Scientists demonstrate that SLIT2 restricts stem cell renewal by signaling through ROBO2 in a subset of basal cells to negatively regulate WNT signaling. [Stem Cell Rep] Full Article | Graphical Abstract


Primary Results of ROSE/TRIO-12, a Randomized Placebo-Controlled Phase III Trial Evaluating the Addition of Ramucirumab to First-Line Docetaxel Chemotherapy in Metastatic Breast Cancer
The ROSE/TRIO-012 trial evaluated ramucirumab with docetaxel in unresectable, locally recurrent, or metastatic breast cancer. [J Clin Oncol] Abstract

Membranous Nectin-4 Expression Is a Risk Factor for Distant Relapse of T1-T2, N0 Luminal-A Early Breast Cancer
Researchers evaluated the association between the expression of Nectin-4 and the clinical outcome of patients with node-negative, T1/T2 breast cancers. The study group consisted of 197 patients presenting with primary unilateral breast carcinoma (T1/T2), with no evidence of nodal involvement and distant metastases. [Oncogenesis] Full Article

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Estrogen Metabolites and Breast Cancer
Scientists’ studies support a role for estradiol metabolism as one of the components in the development of experimental breast cancer. [Steroids] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.
SELLAS Life Sciences Group Signs Exclusive License Agreement for Global Rights on Development and Commercialization of WT1 Cancer Vaccine with Memorial Sloan Kettering Cancer Center
SELLAS Life Sciences Group announced that it has signed an exclusive global collaboration and license agreement with Memorial Sloan Kettering Cancer Center (MSK) for the development, marketing, and commercialization of MSK’s proprietary WT1 cancer vaccine. [SELLAS Life Sciences Group (PR Newswire Association LLC)] Press Release

Rexahn Receives a Notice of Allowance from the U.S. Patent and Trademark Office for a Novel Targeted Cancer Drug Delivery Platform
Rexahn Pharmaceuticals, Inc. announced it has received a notice of allowance from the United States Patent and Trademark Office for a new delivery technology titled, “Polymeric Systems for the Delivery of Anticancer Drugs”. [Rexahn Pharmaceuticals, Inc.] Press Release

From our sponsor: Pluripotent cell isolation for regenerative medicine. Request a free wallchart from Nature.
National Institutes of Health (United States)

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Clinical Applications of Stem Cells (CASC) 2015
February 26-27, 2015
Singapore, Singapore

NEW BIT’s 8th Annual World Cancer Congress (WCC-2015)
May 15-17, 2015
Beijing, China

Visit our events page to see a complete list of events in the mammary cell community.
NEW Postdoctoral Positions – Cell Death of Normal Tissue Stem Cells (Sloan-Kettering Institute)

NEW Postdoctoral Fellow – Breast Cancer Translational Research (University of Houston – College of Pharmacy)

PhD Position – Breast Cancer Stem Cells (University of Copenhagen)

Postdoctoral Fellow – Cancer Biology (The University of Queensland)

Postdoctoral Research Fellow – Cell Cycle Regulatory Pathways in Breast Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Breast Cancer Research (Albert Einstein College of Medicine)

Postdoctoral Fellow – Breast Cancer Metastasis (University of Texas MD Anderson Cancer Center)

Postdoctoral Position – Breast Cancer Research (University of Oklahoma Health Sciences Center)

Scientist – Mammary Cell Research (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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