Tugging on the “Malignant” Switch
Researchers have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer. By isolating mechanical and biological variables one by one in vitro, researchers discovered how the physical forces and chemical environment in those dense tissues can drive cells into a dangerously invasive, proliferating mode. [Press release from Harvard School of Engineering and Applied Sciences discussing online prepublication in Nature Materials]
Press Release|Abstract
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REVIEWS
X-Chromosome Inactivation in Development and Cancer
Sporadic reactivation of X-linked genes has been reported during aging and in transformed cells and disappearance of the Barr body is frequently observed in cancer cells. Authors summarize current knowledge on the epigenetic changes that accompany X inactivation and discuss the extent to which the inactive X chromosome may be epigenetically or genetically perturbed in breast cancer. [FEBS Lett]
Abstract
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INDUSTRY NEWS
Tracking How Breast Cancer Spreads: Einstein Receives $10 Million NIH Grant
The National Cancer Institute, part of the National Institutes of Health (NIH), has awarded a $10 million grant to researchers at Albert Einstein College of Medicine of Yeshiva University to fund research into how breast cancer cells move and spread in the body, and how to predict which breast cancer tumors will metastasize. [Albert Einstein College of Medicine]
Press Release
Response Genetics Launches New Test for Cancer Immunotherapy Drug Development
Response Genetics, Inc. announced the availability of new testing capabilities to advance cancer immunotherapy clinical development. The Immuno-Oncology assay, which runs on HTG Molecular’s Edge System, is designed to measure the RNA expression of 26 commonly investigated immunotherapy related genes enabling screening for response to immunoregulatory pathways. [Response Genetics, Inc.]
Press Release
CSHL Breast Cancer Researcher Mikala Egeblad Wins DoD Era of Hope Scholar Award
Associate Professor Mikala Egeblad, Ph.D. has won an Era of Hope Scholar Award from the United States Department of Defense (DoD) Breast Cancer Research Program. Dr. Egeblad is one of only two recipients of the award this year, and she will receive $2.5 million for her research over the next five years. [Cold Spring Harbor Laboratory (CSHL)]
Press Release
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