| New Test Predicts if Breast Cancer Will Spread |
A test that counts the number of locations in tumor specimens where tumor cells may invade blood vessels predicted the risk of distant spread, or metastasis, for the most common type of breast cancer. The test proved more accurate in predicting the risk of distant tumor spread than a test closely resembling the leading breast cancer prognostic indicator on the market. [Press release from Albert Einstein College of Medicine discussing online prepublication in the Journal of National Cancer Institute] Press Release | Abstract
|PUBLICATIONS (Ranked by impact factor of the journal)|
| LABORATORY RESEARCH|
MicroRNA-205 Signaling Regulates Mammary Stem Cell Fate and Tumorigenesis
Knockdown of microRNA-205 in mammary epithelial cells promoted epithelial-mesenchymal transition, disrupted epithelial cell polarity, and enhanced symmetric division to expand the stem cell population. [J Clin Invest] Full Article
CXCL12-γ in Primary Tumors Drives Breast Cancer Metastasis
To investigate the effects of chemokine C-X-C motif chemokine ligand 12 (CXCL12) isoforms on tumor growth and metastasis, researchers used a mouse xenograft model of metastatic human breast cancer combining CXCR4+ breast cancer cells and mammary fibroblasts secreting an isoform of CXCL12. [Oncogene] Abstract
Mammary Glands Exhibit Molecular Laterality and Undergo Left-Right Asymmetric Ductal Epithelial Growth in MMTV-cNeu Mice
Scientists showed that despite their morphologic symmetry, left versus right mammary glands in wild-type mice have baseline differences in gene expression that are L-R independently regulated during pubertal development, including genes that regulate luminal progenitor cell renewal, luminal cell differentiation, mammary tumorigenesis, tamoxifen sensitivity and chemotherapeutic resistance. [Oncogene] Abstract
A Genomic Analysis of Mouse Models of Breast Cancer Reveals Molecular Features of Mouse Models and Relationships to Human Breast Cancer
The degree to which mouse models model human breast cancer and are reflective of the human heterogeneity has yet to be demonstrated with gene expression studies on a large scale. To this end, researchers have built a database consisting of 1,172 mouse mammary tumor samples from 26 different major oncogenic mouse mammary tumor models. [Breast Cancer Res] Full Article | Press Release
Mesenchymal Precursor Cells Maintain the Differentiation and Proliferation Potentials of Breast Epithelial Cells
Investigators isolated and characterized human breast epithelial and mesenchymal precursors from reduction mammoplasty tissue and tagged them with lentiviral vectors. [Breast Cancer Res] Abstract | Full Article
Obatoclax Analog SC-2001 Inhibits STAT3 Phosphorylation through Enhancing SHP-1 Expression and Induces Apoptosis in Human Breast Cancer Cells
Researchers examined the efficacy and drug mechanism of an obatoclax analog SC-2001, a novel STAT3 inhibitor, in human breast cancer cells. STAT3-regulated proteins, including Mcl-1, survivin, and cyclin D1, were repressed by SC-2001. [Breast Cancer Res Treat] Abstract
Phenotypic Plasticity in Normal Breast Derived Epithelial Cells
Explant culture was utilized to isolate cells from pieces of breast tissue. Selective media and trypsinization were employed to select either epithelial cells or stromal cells. The primary, non-transformed epithelial cells were characterized by immunohistochemistry, flow cytometry, and in vitro cell culture. [BMC Cell Biol]
Abstract | Full Article
Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors
Multipotent progenitors from women aged <30 years were exposed to a physiologically relevant range of matrix elastic modulus (stiffness). Increased stiffness causes a differentiation bias towards myoepithelial cells while reducing production of luminal cells and progenitor maintenance. [Cell Rep]
Abstract | Full Article | Graphical Abstract | Press Release
Final Report of the Phase I/II Clinical Trial of the E75 (nelipepimut-S) Vaccine with Booster Inoculations to Prevent Disease Recurrence in High-Risk Breast Cancer Patients
E75 is a human leukocyte antigen-A2/A3-restricted immunogenic peptide derived from the HER2 protein. Investigators conducted phase I/II clinical trials vaccinating breast cancer patients with nelipepimut-S and GM-CSF in the adjuvant setting to prevent disease recurrence. [Ann Oncol] Abstract
Significant Survival Impact of MACC1 Polymorphisms in HER2 Positive Breast Cancer Patients
Researchers aimed to investigate the influence of metastasis-associated in colon cancer-1 (MACC1) polymorphisms on event-free and overall survival in patients with human epidermal growth factor 2 (HER2)-positive breast cancer. [Eur J Cancer] Abstract
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