| | | PUBLICATIONS (Ranked by impact factor of the journal) |
LABORATORY RESEARCH
Tumor Microenvironment-Based Feed-Forward Regulation of NOS2 in Breast Cancer Progression
Scientists showed that up-regulation of nitric oxide synthase (NOS2) occurs in response to hypoxia, serum withdrawal, IFN-γ, and exogenous nitric oxide (NO), consistent with a feed-forward regulation of NO production by the tumor microenvironment in breast cancer biology. [Proc Natl Acad Sci USA]
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Essential Role for TrpC5-Containing Extracellular Vesicles in Breast Cancer with Chemotherapeutic Resistance
In adriamycin-resistant human breast cancer cells (MCF-7/ADM), investigators analyzed the role of transient receptor potential channel 5 (TrpC5) in extracellular vesicles formation and transfer as well as the diagnostic implications. [Proc Natl Acad Sci USA]
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Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer
Scientists defined activation of extracellular signal-regulated kinase-ribosomal S6 kinase and ETS-like transcription factor 1-CHOP (C-EBP homologous protein) kinase pathways in upregulating transcription of the death receptor 5 (DR5). Through this route, withaferin A acted as an effective DR5 activator capable of potentiating the biologic effects of celecoxib, etoposide, and TRAIL. [Cancer Res]
Abstract
The Sodium Channel β1 Subunit Mediates Outgrowth of Neurite-Like Processes on Breast Cancer Cells and Promotes Tumor Growth and Metastasis
Researchers found that SCN1B mRNA/β1 protein were up-regulated in breast cancer (BCa) specimens, compared with normal breast tissue. β1 up-regulation substantially increased tumor growth and metastasis in a xenograft model of BCa. [Int J Cancer]
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Retinoic Acid Reduces Migration of Human Breast Cancer Cells: Role of Retinoic Acid Receptor Beta
Administration of retinoic acid (RA) in breast cancer cells induced retinoic acid receptor β (RARβ) gene expression that was greatest after 72 hours with a concentration 1 μM. High concentrations of RA increased the expression of RARβ causing an inhibition of the 60% in cell migration and significantly decreased the expression of migration-related proteins. [J Cell Mol Med]
Full Article
Bisphenol AF-Induced Endogenous Transcription Is Mediated by ERα and ERK1/2 Activation in Human Breast Cancer Cells
The authors investigated the effect and mechanism of bisphenol AF (BPAF)-induced endogenous transcription detected by real-time PCR in human breast cancer cells. They found that BPAF stimulated transcription of estrogen responsive genes, such as trefoil factor 1, growth regulation by estrogen in breast cancer 1 and cathepsin D, through dose-dependent and time-dependent manners in T47D and MCF7 cells. [PLoS One]
Full Article
CLINICAL RESEARCH
Phase IIa Trial of Trastuzumab Emtansine with Pertuzumab for Patients with Human Epidermal Growth Factor Receptor 2-Positive, Locally Advanced, or Metastatic Breast Cancer
This Phase IIa study characterized the safety and efficacy of two human epidermal growth factor receptor 2 (HER2)-targeted agents, trastuzumab emtansine and pertuzumab, in patients with HER2-positive metastatic breast cancer. [J Clin Oncol]
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Randomized Phase II Study of Weekly Paclitaxel with and without Carboplatin followed by Cyclophosphamide/Epirubicin/5-Fluorouracil as Neoadjuvant Chemotherapy for Stage II/IIIA Breast Cancer without HER2 Overexpression
Addition of carboplatin to neoadjuvant chemotherapy in HER2-negative breast cancer may improve pathological complete response rates. Investigators evaluated the efficacy and safety of carboplatin and weekly paclitaxel followed by cyclophosphamide, epirubicin, and 5-fluorouracil as neoadjuvant chemotherapy for HER2-negative breast cancer. [Breast Cancer Res Treat]
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| | | REVIEWS |
Breast Cancer Stem Cells: Multiple Capacities in Tumor Metastasis
The authors focus on recently identified key factors, including the breast cancer stem cells (BCSCs) among circulating tumor cells, interaction of BCSCs with the host, epithelial mesenchymal transition, tumor microenvironment, the intrinsic resistance due to HER2 expression, potential biomarkers of BCSCs and cancer cell immune signaling. [Cancer Lett]
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