Volume 6.10 | Mar 20

Mammary Cell News 6.10 March 20, 2014
Mammary Cell News
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The miR-424(322)/503 Cluster Orchestrates Remodeling of the Epithelium in the Involuting Mammary Gland
Researchers identified the microRNA cluster miR-424(322)/503 as an important regulator of epithelial involution after pregnancy. Through the generation of a knockout mouse model, they found that regression of the secretory acini of the mammary gland was compromised in the absence of miR-424(322)/503. [Genes Dev] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)

Genome-Wide Activity of Unliganded Estrogen Receptor-α in Breast Cancer Cells
The authors showed that estrogen receptor-α binds extensively to the genome of breast cancer cells in the absence of estrogen, where it regulates the expression of hundreds of genes endowed with developmental functions. [Proc Natl Acad Sci USA] Abstract

Heterogeneity in ERK Activity as Visualized by In Vivo FRET Imaging of Mammary Tumor Cells Developed in MMTV-Neu Mice
Investigators live-imaged ERK activity in mammary tumors developed in mouse mammary tumor virus (MMTV)-Neu transgenic mice, which had been crossed with transgenic mice expressing a Förster resonance energy transfer (FRET) biosensor for ERK. [Oncogene] Abstract

Hypothalamic Gene Transfer of BDNF Inhibits Breast Cancer Progression and Metastasis in Middle Age Obese Mice
Researchers generated middle age obese mice by high fat diet feeding for a year and investigated the effects of hypothalamic gene transfer of brain-derived neurotrophic factor (BDNF) on a hormone receptor positive mammary tumor model. [Mol Ther] Abstract

Receptor-Interacting Protein Kinase 2 Promotes Triple-Negative Breast Cancer Cell Migration and Invasion via Activation of Nuclear Factor-KappaB and C-Jun N-Terminal Kinase Pathways
Investigators demonstrate that receptor-interacting protein kinase 2, a kinase known to be involved in inflammatory processes, also has novel roles in cancer cell migration and invasion. [Breast Cancer Res] Abstract | Full Article

N-Myc Downstream-Regulated Gene 2 Expression Is Associated with Glucose Transport and Correlated with Prognosis in Breast Carcinoma
The authors investigated whether N-myc downstream-regulated gene 2 is involved in any glucose-dependent energy metabolism, and the nature of its correlation with breast carcinoma. [Breast Cancer Res]
Abstract | Full Article

Snail Family Members Unequally Trigger EMT and Thereby Differ in Their Ability to Promote the Neoplastic Transformation of Mammary Epithelial Cells
The authors demonstrated that when a SNAIL protein is ectopically produced in non-transformed mammary epithelial cells, the cells are protected from anoikis and proliferate under low-adherence conditions: a hallmark of cancer cells. [PLoS One] Full Article

Functional Proteomic Analysis Reveals the Involvement of KIAA1199 in Breast Cancer Growth, Motility and Invasiveness
Reearchers examined the functional significance of KIAA1199 expression in breast cancer growth, motility and invasiveness. [BMC Cancer] Abstract | Full Article

Extracellular Matrix Signatures of Human Mammary Carcinoma Identify Novel Metastasis Promoters
The authors used proteomics to investigate the extracellular matrix (ECM) of human mammary carcinoma xenografts and showed that primary tumors of differing metastatic potential differ in ECM composition. [eLife] Abstract | Press Release


PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ-Implications for Progression to Invasive Breast Carcinoma
The authors assessed the prevalence of phosphoinositide 3-kinase (PI3K) pathway alterations in pure high-grade ductal carcinoma in situ (DCIS) and DCIS associated with invasive breast cancer (IBC), and determined whether DCIS and adjacent IBCs harbor distinct PI3K pathway aberrations. [Clin Cancer Res] Abstract

Androgen Receptor Expression Shows Distinctive Significance in ER Positive and Negative Breast Cancers
To investigate the clinical significance of androgen receptor (AR) in breast cancers more precisely, the expression of AR in a large cohort of breast cancer was correlated with clinicopathological features, biomarker expression, and patients’ survival according to different molecular groupings. [Ann Surg Oncol] Abstract

Serum Soluble ST2 Is Associated with ER-Positive Breast Cancer
The serum levels of interleukin-33, sST2, and vascular endothelial growth factor in 150 breast cancer patients and 90 healthy women were measured by enzyme-linked immunosorbent assay. Estrogen receptor (ER), progesterone receptor, human epithelial receptor-2, and cell cycle regulated protein Ki-67 were measured. [BMC Cancer] Abstract | Full Article

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Rewiring Cell Polarity Signaling in Cancer
The authors discuss recent advances in our understanding of how polarity proteins regulate diverse signaling pathways throughout cancer progression from initiation to metastasis. [Oncogene] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.
Breast Cancer Pilot Projects Begin at University of Hull
Two pilot research projects at the University of Hull aim to develop new diagnostic tests and potential treatment options for breast cancer. The projects have been made possible thanks to grants worth £40,000 (£20,000 each) awarded by breast cancer research charity Breast Cancer Campaign. [University of Hull] Press Release

Ohio State Partners with MedVax Technologies, Inc. to Bring a Cancer Peptide Vaccine to Patients
The Ohio State University, through the Ohio State Innovation Foundation, has signed an exclusive world-wide licensing agreement with MedVax Technologies, Inc., for the licensing of groundbreaking cancer peptide vaccine technologies. [The Ohio State University] Press Release

MD Anderson, MedImmune Join Forces to Advance Cancer Immunotherapy
The University of Texas MD Anderson Cancer Center and MedImmune will collaborate through MD Anderson’s Moon Shots Program to develop therapies that unleash patients’ immune systems to attack their cancers. [The University of Texas MD Anderson Cancer Center] Press Release

NRC and Zymeworks Partner to Develop Ground-Breaking Canadian Therapies for the Fight Against Cancer
The National Research Council of Canada (NRC) and Zymeworks Inc. announced a strategic collaborative agreement for a continued innovative business alliance. This three-year multi-million dollar agreement will focus on developing ground-breaking therapies for the fight against cancer, as well as inflammatory and autoimmune diseases. [Zymeworks Inc.] Press Release

Acclaimed British Scientist Named Head of UCSF Helen Diller Cancer Center
One of the world’s preeminent cancer scientists, Alan Ashworth, PhD, FRS, has been appointed the new director of the University of California San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center. [University of California San Francisco] Press Release

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Alliance for Regenerative Medicine Announces Introduction of Regenerative Medicine Promotion Act of 2014 in the Senate
The Alliance for Regenerative Medicine announced the introduction of the Regenerative Medicine Promotion Act of 2014 in the U.S. Senate and expressed appreciation for the efforts of its lead sponsors, Senators Barbara Boxer (D-CA) and Mark Kirk (R-IL). [Alliance for Regenerative Medicine] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW The Australia & New Zealand Breast Cancer Trials Group 36th Annual Scientific Meeting
July 16-19, 2014
Wellington, New Zealand

NEW 7th Annual Royal Marsden Breast Cancer Meeting: Hot Topics in Breast Cancer
October 3, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the mammary cell community.
NEW Junior Faculty Position – Breast Pathology (Northwestern University)

NEW Vice President, Global Medical Affairs – Breast Disease Lead (Celgene Corporation)

Research Assistant – Breast Epithelial Cell Research (Mount Sinai Medical Center/Icahn School of Medicine at Mount Sinai)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Positions – Breast Cancer (Karolinska Institute)

Postdoctoral Fellow – Mechanisms that Contribute to Metastases of Breast Cancer Cells (Mount Sinai Medical Center/Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Hodgkin Lymphoma and Breast Cancer (Hackensack University Medical Center)

Postdoctoral Position – Functions of Epigenetic Enzymes in Breast Cancer (University of Wisconsin-Madison)

Postdoctoral Position – Breast Cancer Metastasis (Weizmann Institute of Science)

Postdoctoral Research Fellow (Brigham & Women’s Hospital and Harvard Medical School)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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