Volume 6.03 | Jan 30

Mammary Cell News 6.03 January 30, 2014
Mammary Cell News
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Long-Lived Breast Stem Cells Could Retain Cancer Legacy
Researchers have discovered that breast stem cells and their ‘daughters’ have a much longer lifespan than previously thought, and are active in puberty and throughout life. [Press release from The Walter and Eliza Hall Institute of Medical Research discussing online prepublication in Nature] Press Release | Abstract | Video
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PUBLICATIONS (Ranked by impact factor of the journal)

STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF-?B to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes
Researchers found that the gene encoding the tumor suppressor microRNA miR-146b is a direct signal transducer and activator of transcription 3 (STAT3) target gene, and its expression was increased in normal breast epithelial cells but decreased in tumor cells. [Sci Signal] Abstract

Akt Phosphorylates and Activates HSF-1 Independent of Heat Shock, Leading to Slug Overexpression and Epithelial-Mesenchymal Transition (EMT) of HER2-Overexpressing Breast Cancer Cells
Researchers observed that heregulin-mediated activation of HER2, or HER2 overexpression, resulted in EMT, which is accompanied with increased expression of a known EMT regulator Slug, but not TWIST or Snail. [Oncogene] Abstract

Growth Factor Receptor/Steroid Receptor Cross Talk in Trastuzumab-Treated Breast Cancer
Researchers investigated the cross talk between HER2 and ER in breast cancer and monitored the effect of trastuzumab on the tyrosine kinase effector transcription factor Myc. [Oncogene] Abstract

The Aryl Hydrocarbon Receptor Mediates Raloxifene-Induced Apoptosis in Estrogen Receptor-Negative Hepatoma and Breast Cancer Cells
Raloxifene selectively induced apoptosis of triple-negative MDA-MB-231 breast cancer cells compared with non-transformed mammary epithelial cells via the aryl hydrocarbon receptor. [Cell Death Dis] Full Article

Kindlin-3 Enhances Breast Cancer Progression and Metastasis by Activating Twist-Mediated Angiogenesis
Scientists examined the relationship between Kindlin-3 and breast cancer in mouse models and human tissues. Kindlin-3 overexpression in a breast cancer cell line increased primary tumor growth and lung metastasis by 2.5- and 3-fold, respectively, when implanted into mice compared with cells expressing vector alone. [FASEB J] Abstract

Resveratrol Mediated Cell Death in Cigarette Smoke Transformed Breast Epithelial Cells Is through Induction of p21Waf1/Cip1 and Inhibition of Long Patch Base Excision Repair Pathway
Researchers studied the mechanism of resveratrol (Res) mediated apoptosis in cigarette smoke condensate transformed (MCF-10A-Tr) cells in vitro and in vivo. Res mediated apoptosis in MCF-10A-Tr cells was a p21 dependent event. [Toxicol Appl Pharmacol] Abstract

Molecular Characterization of Exosome-Like Vesicles from Breast Cancer Cells
Proteomic profiling of vesicles using liquid chromatography-mass spectrometry revealed different protein profiles of exosome-like vesicles derived from MCF-7 cells than those from MDA-MB 231 cells. [BMC Cancer]
Abstract | Full Article

Critical Role of miR-10b in Transforming Growth Factor-ß1-Induced Epithelial-Mesenchymal Transition in Breast Cancer
MicroRNA-10b (miR-10b) was found to be upregulated in breast cancer tissues and breast cancer cell lines and the expression of miR-10b was shown to be closely correlated with aggressiveness in breast cancer. [Cancer Gene Ther] Full Article

Spheroid Formation and Invasion Capacity Are Differentially Influenced by Co-Cultures of Fibroblast and Macrophage Cells in Breast Cancer
The contribution of fibroblast and/or macrophage cells on the malignant behavior of breast cancer cells was modeled in co-culture systems. [Mol Biol Rep] Abstract


Phase Ib Study of Buparlisib Plus Trastuzumab in Patients with HER2-Positive Advanced or Metastatic Breast Cancer that Has Progressed on Trastuzumab-Based Therapy
Investigators determine the clinical activity of the phosphatidylinositol 3-kinase inhibitor buparlisib in patients with HER2-positive advanced/metastatic breast cancer resistant to trastuzumab-based therapy. [Clin Cancer Res] Abstract

A Phase II Study of Preoperative Capecitabine in Women with Operable Hormone Receptor Positive Breast Cancer
Researchers hypothesized that capecitabine, which is effective in metastatic breast cancer, may be an active preoperative treatment for hormone receptor positive (HR+) breast cancer. Women with HR+, HER2-negative operable breast cancer received capecitabine, 2000 mg/m2 daily in divided doses for 14 days, followed by a 7-day rest period. [Cancer Med] Full Article

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Reproductive Risk Factors and Breast Cancer Subtypes: A Review of the Literature
The authors conducted a review of the literature and summarized the results of associations between reproductive factors and risk or odds of three distinct tumor subtypes: estrogen receptor/progesterone receptor positive, tumors overexpressing the human epidermal receptor 2 protein, and triple negative breast cancer, which lacks the three markers. [Breast Cancer Res Treat] Full Article

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Rutgers Cancer Institute of New Jersey Researchers Awarded $240K to Explore Breast Cancer Treatment Implications in Gene Fusion Study
The Breast Cancer Research Foundation has awarded a pair of investigators at Rutgers Cancer Institute of New Jersey a one-year, $240,000 grant to examine treatment implications for a genetic variation found in a quarter of Caucasians and in a small percentage of Caucasian breast cancer patients. [Rutgers Cancer Institute of New Jersey] Press Release

Curie-Cancer and Servier Continue a Renewed Partnership in Cancer Research
Curie-Cancer and Servier announced that they have renewed their partnership with the aim of identifying therapeutic targets for treating ‘triple negative’ breast cancers. [Servier] Press Release

Minister Sherlock Opens Ireland’s First Human Use Stem Cell Manufacturing Facility at NUI Galway
The Centre for Cell Manufacturing Ireland at National University of Ireland Galway is the first ever facility on the island of Ireland to receive a license from the Irish Medicines Board to manufacture culture-expanded stem cells for human use. [National University of Ireland, Galway] Press Release

Stem Cell Agency Funds More Than $66 Million in Research Including New Genomics Initiative
A team bringing together experts and investigators from seven different major California institutions has been awarded $40 million to create a new Center of Excellence in Stem Cell Genomics, by California’s stem cell agency, the California Institute for Regenerative Medicine. [California Institute for Regenerative Medicine]
Press Release

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NEW International Society for Cellular Therapy (ICST) 2014
April 23-26, 2014
Paris, France

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NEW Clinical Research Fellow – Pathology (Institute of Cancer Research)

NEW Postdoctoral Fellow – Hodgkin Lymphoma and Breast Cancer (Hackensack University Medical Center)

NEW Postdoctoral Position – Functions of Epigenetic Enzymes in Breast Cancer (University of Wisconsin-Madison)

Postdoctoral Position – Breast Cancer Metastasis (Weizmann Institute of Science)

Postdoctoral Fellow – Morphogenetic Signaling Pathways in Development and Disease (University of Rochester Medical Center)

PhD Scholarship – Chromosome Instability in Breast Cancer (The University of Queensland)

Postdoctoral Research Fellow (Brigham & Women’s Hospital and Harvard Medical School)

Postdoctoral Position – Stem Cells and Cancer (Brigham & Women’s Hospital – Harvard Medical School)

Postdoctoral Associate – Breast Cancer Development (University of Pittsburgh Cancer Institute)

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