Volume 5.50 | Dec 19

Mammary Cell News 5.50 December 19, 2013
Mammary Cell News
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Increased Sugar Uptake Promotes Oncogenesis via EPAC/RAP1 and O-GlcNAc Pathways
Researchers provide evidence that increased glycolytic activation itself can be an oncogenic event in a physiologically relevant 3D culture model. Overexpression of glucose transporter type 3 in nonmalignant human breast cells activated known oncogenic signaling pathways, including EGFR, β1 integrin, MEK, and AKT, leading to loss of tissue polarity and increased growth. [J Clin Invest] Abstract | Press Release
Culture and Characterize Human Mammary Epithelial Progenitors with Serum-Free EpiCult-B (Human)
PUBLICATIONS (Ranked by impact factor of the journal)

TGF-Beta Receptor Type-2 Expression in Cancer-Associated Fibroblasts Regulates Breast Cancer Cell Growth and Survival and Is a Prognostic Marker in Pre-Menopausal Breast Cancer
To determine the role of the fibroblastic transforming growth factor-beta (TGF-β) pathway in breast cancer cells, researchers used cell contact-dependent cell growth and clonogenicity assays, which showed that knockdown of TGFB receptor type 2 in cancer-associated fibroblasts resulted in increased cell growth, proliferation and clonogenic survival. [Oncogene] Abstract

Inhibition of Insulin-Like Growth Factor Binding Protein-3 Signaling through Sphingosine Kinase 1 Sensitizes Triple-Negative Breast Cancer Cells to EGF Receptor Blockade
Scientists investigated whether co-targeting the epidermal growth factor receptor (EGFR) and SphK1/S1P pathways in triple-negative breast cancer (TNBC) cells causes increased growth inhibition compared to blocking either alone, and might therefore have novel therapeutic potential in TNBC. [Mol Cancer Ther] Abstract

Evidence that Estrogen Receptor α Interferes with Adiponectin Effects on Breast Cancer Cell Growth
Researchers demonstrated that adiponectin induces a dichotomic effect on breast cancer growth. It stimulates growth in ERα+ MCF-7 cells while inhibiting proliferation of ERα- MDA-MB-231 cells. Notably, only in MCF-7 cells adiponectin exposure exerts a rapid activation of MAPK phosphorylation, which was markedly reduced when knockdown of the ERα gene occurred. [Cell Cycle] Abstract

Human Breast Tumor Cells Are More Resistant to Cardiac Glycoside Toxicity than Non-Tumorigenic Breast Cells
The authors investigated the effects of cardiotonic steroids compounds, ouabain, digitoxin, and bufalin, on cell growth and survival in cell lines exhibiting the full spectrum of non-cancerous to malignant phenotypes. [PLoS One] Full Article

Lin28 Induces Epithelial-to-Mesenchymal Transition and Stemness via Downregulation of Let-7a in Breast Cancer Cells
Investigators previously demonstrated that let-7 regulates self-renewal and tumorigenicity of breast cancer stem cells. In this study, they demonstrated that Lin28 was highly expressed in mesenchymal type cells, but it was barely detectable in epithelial type cells. [PLoS One] Full Article

In Vitro Assessment of the Effects of Anti-HER2 Monoclonal Antibodies on Proliferation of HER2-Overexpressing Breast Cancer Cells
Researchers recently established a panel of anti-HER2 monoclonal antibodies (mAbs) recognizing different epitopes within the extracellular domain of HER2. The antiproliferative effect of these mAbs were investigated on HER2-overexpressing human breast cancer cell line BT474, using radioactive thymidine incorporation assay. [Immunotherapy] Abstract


Epirubicin and Docetaxel with or without Capecitabine as Neoadjuvant Treatment for Early Breast Cancer: Final Results of a Randomized Phase III Study
This randomized Phase III trial compared pathologic complete response rates of early breast cancer following neoadjuvant epirubicin-docetaxel ± capecitabine, and evaluated the addition of trastuzumab in HER2-positive tumors. [Ann Oncol] Abstract

Role of HER3 Expression and PTEN Loss in Patients with HER2-Overexpressing Metastatic Breast Cancer (MBC) Who Received Taxane plus Trastuzumab Treatment
Scientists investigated the role of human epidermal growth factor receptor (HER3) and PTEN expression in patients with HER2-overexpressing MBC. One hundred twenty-five MBC patients who were treated with taxane plus trastuzumab chemotherapy as first-line therapy were included in this analysis. [Brit J Cancer] Abstract

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How Pregnancy at Early Age Protects against Breast Cancer
Recent studies in epithelial cell subpopulations isolated from mouse and human mammary glands have shown that early pregnancy decreases the proportion of hormone receptor-positive cells and causes pronounced changes in gene expression as well as decreased proliferation in stem/progenitor cells. These new findings highlight the importance of cell-cell interactions within the mammary gland epithelium in modulating cancer risk and provide potential targets for breast cancer prevention strategies. [Trends Mol Med] Abstract

Adoptive Immunotherapy of Metastatic Breast Cancer: Present and Future
This review aims to dissect bone marrow-derived cellular antitumor immune responses and translational immunologic treatment options regarding their actual relevance to patients’ clinical benefit and their future directions in breast cancer management. [Cancer Metastasis Rev] Abstract

The Biology of Zinc Transport in Mammary Epithelial Cells: Implications for Mammary Gland Development, Lactation, and Involution
The authors review the current understanding of the molecular mechanisms through which mammary epithelial cells utilize zinc with a focus on the transport of zinc into discrete subcellular organelles for specific cellular functions during mammary gland development, lactation, and involution. [J Mammary Gland Biol Neoplasia] Abstract

Visit our reviews page to see a complete list of reviews in the mammary cell research field.
Changing Chemotherapy Not Beneficial for Metastatic Breast Cancer Patients with Elevated Circulating Tumor Cells
For women with metastatic breast cancer who had elevated amounts of circulating tumor cells in their blood after a first line of chemotherapy, switching immediately to a different chemotherapy did not improve overall survival or time to progression, according to the results of a phase III clinical trial. [Press release from the American Association for Cancer Research discussing research presented at the 2013 San Antonio Breast Cancer Symposium, San Antionio] Press Release

Additional Drug Shows Promise for Women with Triple-Negative Breast Cancer
In a nationwide study of women with triple-negative breast cancer, adding the chemotherapy drug carboplatin or the angiogenesis inhibitor Avastin to standard chemotherapy drugs brought a sharp increase in the number of patients whose tumors shrank away completely. [Press release from Dana-Farber Cancer Institute discussing research presented at the 2013 San Antonio Breast Cancer Symposium, San Antionio] Press Release

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Study Shows New Paradigm in Breast Cancer Research
Results from an unprecedented nationwide effort to test promising new breast cancer drugs before the tumor is removed were presented. The research initiative, called I-SPY 2, employs an innovative clinical trial design in the curative setting that is enabling researchers to quickly drop drugs and drug combinations that don’t work, while fast-tracking effective regimens for further study. [EurekAlert!] Press Release

Ventana Announces HER2 Companion Diagnostic to Identify Breast Cancer Patients for Roche’s Latest Targeted Medicines, Perjeta and Kadcyla
Ventana Medical Systems, Inc. announced the VENTANA HER2/neu Rabbit Monoclonal Primary Antibody assay as a companion diagnostic for detecting HER2 protein expression for patients who, in countries where they are approved, may be appropriate candidates for Perjeta® and KadcylaTM. [Ventana Medical Systems, Inc.] Press Release

VM Medical Center in Montreal Has Successfully Treated Its First Patient
Medifocus, Inc. announced that VM Medical Center in Montreal, its Principal Investigational Site in Canada for its APA-1000 Focused Microwave Breast Thermotherapy System Pivotal Phase III clinical study has successfully treated its first patient enrolled. [Medifocus, Inc.] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW Controlling Cancer Summit
May 12-14, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the mammary cell community.
NEW Postdoctoral Position – Breast Cancer Signaling (Weizmann Institute of Science)

Postdoctoral Associate – Breast Cancer Development (University of Pittsburgh Cancer Institute)

Postdoctoral Scholar – Breast Cancer Research (Northwestern University)

Clinical MD – Clinical Development Program for Oncology and Autoimmune Diseases (Immunomedics, Inc.)

Chief Medical Officer – Novel Therapeutics in Oncology and Autoimmune Disease (Immunomedics, Inc.)

PhD Position – Integrated Classification of Breast Cancers to Optimize Treatment Protocols (Radboud University Nijmegen Medical Centre)

Assistant, Associate, or Research Professor – Breast Cancer (Indiana University School of Medicine)

Postdoctoral Fellow – Breast Cancer Stem Cell Biology (UC – College of Medicine)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

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