Volume 5.12 | Mar 28

Mammary Cell News 5.12 March 28, 2013
Mammary Cell News
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Hunk Negatively Regulates c-myc to Promote Akt-Mediated Cell Survival and Mammary Tumorigenesis Induced by Loss of Pten
Researchers report that Hormonally up-regulated neu-associated kinase (Hunk) is required for c-myc suppression and mammary tumorigenesis induced by phosphatase and tensin homolog (Pten) deletion in mice. Together, their findings establish a prosurvival function for Hunk in tumorigenesis, define an essential mechanism by which Akt suppresses c-myc-induced apoptosis, and identify Hunk as a previously unrecognized link between the Akt and c-myc oncogenic pathways. [Proc Natl Acad Sci USA] Full Article

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PUBLICATIONS (Ranked by impact factor of the journal)


Functional Cooperation of miR-125a, miR-125b, and miR-205 in Entinostat-Induced Downregulation of erbB2/erbB3 and Apoptosis in Breast Cancer Cells
Researchers demonstrated that entinostat specifically induces expression of microRNA (miR)-125a, miR-125b, and miR-205, which act in concert to downregulate erbB2/erbB3 in breast cancer cells. [Cell Death Dis] Full Article

Nox4-Dependent Reactive Oxygen Species Modulation by Amino Endoperoxides to Induce Apoptosis in Cancer Cells
The authors describe a one-pot strategy to synthesize novel amino endoperoxides and their derivatives with good yields and stabilities. In vitro cell-based assays revealed that four out of the 14 amino endoperoxides selectively induce metastatic breast carcinoma cells but not normal breast cells to undergo apoptosis, in a dose-dependent manner. [Cell Death Dis] Full Article

EpCAM Expression Varies Significantly and Is Differentially Associated with Prognosis in the Luminal B HER2+, Basal-Like, and HER2 Intrinsic Subtypes of Breast Cancer
To investigate the association between epithelial cell adhesion molecule (EpCAM) expression and prognosis in the intrinsic subtypes of breast cancer, the authors performed immunohistochemical studies on a tissue microarray encompassing a total of 1365 breast cancers with detailed clinicopathological annotation and outcomes data. [Br J Cancer] Abstract

KISS1R Induces Invasiveness of Estrogen Receptor-Negative Human Mammary Epithelial and Breast Cancer Cells
Researchers report that either kisspeptin-10 treatment of estrogen receptor (ER)α-negative non-malignant mammary epithelial MCF10A cells or expression of KISS1R in MCF10A cells induced a mesenchymal phenotype and stimulated invasiveness. Similarly, exogenous expression of KISS1R in ERα-negative SKBR3 breast cancer cells was sufficient to trigger invasion and induced extravasation in vivo. [Endocrinology] Abstract

Syndecan Binding Protein (SDCBP) Is Overexpressed in Estrogen Receptor Negative Breast Cancers, and Is a Potential Promoter for Tumor Proliferation
SDCBP, an adapter protein containing PDZ domains, contributes to the tumorigenicity and metastasis of many malignant tumors, such as malignant melanoma. Scientists examined the expression profile of SDCBP in breast cancer (BCa) and its role in tumor cell proliferation, and then exploring its value in the targeted treatment of BCa. [PLoS One] Full Article

BRG1 Is a Prognostic Marker and Potential Therapeutic Target in Human Breast Cancer
Researchers explored the role of BRG1 in human breast cancer pathogenesis. Using tissue microarray and immunohistochemistry, they evaluated BRG1 staining in 437 breast cancer specimens and investigated its role in breast cancer cell proliferation, migration and invasion. [PLoS One] Full Article

Targeting Heat Shock Proteins by Phenethyl Isothiocyanate Results in Cell-Cycle Arrest and Apoptosis of Human Breast Cancer Cells
Researchers aimed to determine the effect of natural isothiocyanate (phenethyl isothiocyanate) on different heat shock proteins and heat shock factor 1 in two breast cancer cell lines, namely breast adenocarcinoma MCF-7 (with wild type p53) and highly metastatic breast cancer cell MDA-MB-231 (with mutated p53). [Nutr Cancer] Abstract


Large-Scale Genotyping Identifies 41 New Loci Associated with Breast Cancer Risk
The authors report a meta-analysis of nine genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which they selected 29,807 SNPs for further genotyping. They identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance. [Nat Genet] Abstract | Press Release

Enrichment of Regulatory T Cells in Invasive Breast Tumor Correlates with the Upregulation of IL-17A Expression and Invasiveness of the Tumor
Researchers found that regulatory T (Treg) and Th17 cells can affect disease progression by Treg-cell-mediated suppression of the effector T-cell response, as indicated by a decrease in the proliferation of T cells isolated from PBMCs of invasive ductal carcinoma of the breast patients and induction of angiogenic factors by IL-17-producing Th17. [Eur J Immunol] Abstract

Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) as a Prognostic Marker for Local Control in T1-2 N0 Breast Cancer Treated with Breast-Conserving Surgery and Radiation Therapy (BCS + RT)
Researchers evaluated the prognostic significance of IFIT1 protein expression in patients with breast cancer treated with BCS + RT. A tissue microarray was constructed with specimens from 282 women with node-negative, early-stage (I/II) breast cancer who were treated with BCS + RT. Immunohistochemistry was used to stain for the IFIT1 protein. [Breast J] Abstract

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The Role of Intratumoral and Systemic IL-6 in Breast Cancer
The authors review the associations between IL-6 and breast cancer ranging from in vitro cell culture studies to clinical studies, covering the role of IL-6 in controlling breast cancer cell growth, regulation of cancer stem cell renewal, as well as breast cancer cell migration. [Breast Cancer Res Treat] Abstract

A Bi-Faceted Role of Estrogen Receptor Beta in Breast Cancer
In clinical studies and most often in cell culture studies, the pro-growth and pro-survival activity of estrogen receptor (ER) beta occurs in ER alpha negative breast cancer tissue and cells. This bi-faceted role of ER beta is reviewed. [Endocr Relat Cancer] Full Article

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Varian Medical Systems Highlights Calypso® System and Other Technologies Designed to Help Reduce the Risk of Heart Disease after Radiotherapy for Breast Cancer
Varian Medical Systems is highlighting its Calypso® System as a tool designed to help doctors reduce women’s risk of developing heart disease years after treatment for breast cancer. The system uses GPS for the Body® technology to help minimize exposure of the heart during treatment for breast cancer. [Varian Medical Systems] Press Release

Susan G. Komen for the Cure® Announces New Grants and Partnership with the National Football League Players Association to Kick Off the 2013 Global Race for the Cure
Susan G. Komen for the Cure®, the world’s leading breast cancer organization, announced $1.5 million in new D.C.-area community health grants at an event that also marked the kickoff of a new partnership with the NFL Players’ Association. [Susan G. Komen] Press Release

Hologic’s “3D Technology: A More Accurate Mammogram” Mobile Coach Tour Makes Special Stop at National Consortium of Breast Center’s Annual Conference in Las Vegas
Hologic, Inc. brought its “3D Technology: A More Accurate Mammogram ” mobile coach tour to the National Consortium of Breast Center’s (NCBC) 23rd Annual National Interdisciplinary Breast Center Conference in Las Vegas, Nevada. [Hologic, Inc.] Press Release

AACR Elects Carlos L. Arteaga, M.D., as President-Elect 2013-2014
The members of the American Association for Cancer Research (AACR) have elected Carlos L. Arteaga, M.D., as their president-elect for 2013-2014. Arteaga is a professor of medicine and cancer biology at Vanderbilt University School of Medicine where he holds the Donna S. Hall chair in breast cancer research. He also serves as associate director for clinical research and director of the Breast Cancer Research Program at Vanderbilt-Ingram Cancer Center in Nashville, Tenn. [American Association for Cancer Research]
Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW Chromatin and Epigenetics in Cancer
June 19-22, 2013
Atlanta, United States

Visit our events page
 to see a complete list of events in the mammary cell community.

Research Fellow – Breast Cancer Research (Monash University)

PhD Studentship – Signal Transduction and Cancer Research (McGill University)

Postdoctoral Position – Breast Cancer Research (Albert Einstein College Medicine)

Postdoctoral Position – Breast Cancer Research (Weizmann Institute of Science)

Postdoctoral Position – Hypoxia Signaling, Prolyl Hydroxylases and Cancer (UNC-Chapel Hill)

Postdoctoral Position – Breast Cancer (UT Southwestern Medical Center at Dallas)

Product Director – Breast Marketing (Genomic Health)

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