Volume 5.04 | Jan 31

Mammary Cell News 5.04 January 31, 2013
Mammary Cell News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
GATA3 Suppresses Metastasis and Modulates the Tumor Microenvironment by Regulating MicroRNA-29b Expression
Scientists showed that GATA3 promotes differentiation, suppresses metastasis and alters the tumor microenvironment in breast cancer by inducing microRNA-29b (miR-29b) expression. Accordingly, miR-29b is enriched in luminal breast cancers and loss of miR-29b, even in GATA3-expressing cells, increases metastasis and promotes a mesenchymal phenotype. [Nat Cell Biol] Abstract | Press Release

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PUBLICATIONS (Ranked by impact factor of the journal)

LABORATORY RESEARCH

WNT10B/β-Catenin Signaling Induces HMGA2 and Proliferation in Metastatic Triple-Negative Breast Cancer
Scientists illustrate that WNT10B induces transcriptionally active β-catenin in human triple-negative breast cancers (TNBC) and predicts survival-outcome of patients with both TNBC and basal-like tumors. [EMBO Mol Med] Full Article

KLF6-SV1 Drives Breast Cancer Metastasis and Is Associated with Poor Survival
Researchers demonstrated that KLF6-SV1, an oncogenic splice variant of the KLF6 tumor suppressor gene, is associated with increased metastatic potential and poor survival in a cohort of 671 lymph node-negative breast cancer patients. KLF6-SV1 overexpression in mammary epithelial cell lines resulted in an epithelial-to-mesenchymal-like transition and drove aggressive multiorgan metastatic disease in multiple in vivo models. [Sci Transl Med] Abstract | Press Release

Crosstalk between Lysine-Specific Demethylase 1 (LSD1) and Histone Deacetylases Mediates Antineoplastic Efficacy of HDAC Inhibitors in Human Breast Cancer Cells
Scientists showed that knockdown of LSD1 expression by RNAi decreased mRNA levels of histone deacetylase (HDAC) isozymes in triple-negative breast cancer cells. [Carcinogenesis] Abstract

Mitochondrial-Dependent Anticancer Activity of δ-Tocotrienol and Its Synthetic Derivatives in HER-2/neu Overexpressing Breast Adenocarcinoma Cells
Anticancer activity and mitochondrial mechanism of the vitamin E form δ-tocotrienol was investigated in HER-2/neu-overexpressing human SKBR3 and murine TUBO breast cancer cells. [Biofactors] Abstract

Lapatinib-Mediated Cyclooxygenase-2 Expression via EGFR/HuR Interaction Enhances the Aggressiveness of Triple-Negative Breast Cancer Cells
The authors demonstrated that lapatinib facilitated axillary and lung metastases of triple-negative MDA-MB-231 breast cancer cells without affecting their viability, leading to worse survival in orthotopic xenograft mice. [Mol Pharmacol] Abstract

Mesenchymal and Stem-Like Cell Properties Targeted in Suppression of Chronically-Induced Breast Cell Carcinogenesis
The authors investigated stem-like cell- and epithelial-to-mesenchymal transition-associated properties and markers in breast epithelial cells chronically exposed to low-dose 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene in the presence and absence of the preventive agents green tea catechins and grape seed extract. [Cancer Lett] Abstract

Phenotypic Switch in Blood: Effects of Pro-Inflammatory Cytokines on Breast Cancer Cell Aggregation and Adhesion
Scientists hypothesized that human plasma, 3-D tumor spheroid culture, and cytokine-supplemented culture media could induce a phenotypic switch that allows breast cancer cells to interact with E-selectin coated surfaces under physiological flow. [PLoS One] Full Article | Press Release

Antiproliferative Effects of Pomegranate Extract in MCF-7 Breast Cancer Cells Are Associated with Reduced DNA Repair Gene Expression and Induction of Double Strand Breaks
While pomegranate extract (PE) is a potent antioxidant, researchers conducted studies to examine the mechanisms of action of PE beyond antioxidation by studying cellular and molecular mechanisms underlying breast tumorigenesis. [Mol Carcinog] Abstract

CLINICAL RESEARCH
 
Survival after Lumpectomy and Mastectomy for Early Stage Invasive Breast Cancer
A large, population-based series of women who underwent breast-conserving therapy with radiation or mastectomy was studied to observe whether outcomes of randomized clinical trials were achieved in the general population, and whether survival differed by surgery type when stratified by age and hormone receptor status. [Cancer] Abstract | Press Release

Associations of Serum 25-Hydroxyvitamin D with Overall and Breast Cancer-Specific Mortality in a Multiethnic Cohort of Breast Cancer Survivors
In the Health, Eating, Activity, and Lifestyle study, investigators examined associations of post-treatment serum concentrations of 25-hydroxyvitamin D on overall and breast cancer-specific mortality in 585 breast cancer survivors. [Cancer Causes Control] Abstract

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REVIEWS
Estrogen-Related Receptors in Breast Cancer: Control of Cellular Metabolism and Beyond
In the context of breast cancer, the estrogen-related receptors (ERRs) affect cellular metabolism in a manner that promotes a Warburg-like phenotype. The ERRs also modulate breast cancer cell metabolism, growth and proliferation through the regulation of key oncoproteins. The authors discuss the value but also the implications of the complexity of targeting the ERRs for the development of cancer therapeutics. [Nat Rev Cancer] Abstract

Mammary Stem Cell Research in Veterinary Science: An Update
This review summarizes the current knowledge on stem cell isolation and characterization in different mammals of veterinary importance. [Stem Cells Dev] Abstract
INDUSTRY NEWS

Generex Points to Potential of Antigen Express Technology Platform beyond Its AE37 Breast Cancer Vaccine
Generex Biotechnology Corporation explained the potential of the technology platform used as the basis for its novel breast cancer immunotherapy product AE37. AE37 is currently in late Phase IIb clinical development and has garnered considerable attention based upon favorable results from interim analysis of its controlled, randomized, and blinded trial in women with early stage breast cancer. [Generex Biotechnology Corporation] Press Release

Ultrasound Breast Cancer Imaging Device Created at the Karmanos Cancer Institute One Step Closer to FDA Approval
SoftVue, the whole breast ultrasound imaging device created by two scientists from the Barbara Ann Karmanos Cancer Institute and Wayne State University School of Medicine, is currently undergoing review by the U.S. Food and Drug Administration (FDA) for market clearance. [Karmanos Cancer Institute]
Press Release

POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW 11th Cancer Immunotherapy (CIMT) Annual Meeting 
May 14-16, 2013
Mainz, Germany

Visit
our events page to see a complete list of events in the mammary cell community.

JOB OPPORTUNITIES

Postdoctoral Position – Gene Regulation in Breast Cancer/Stem Cell Biology (UC College of Medicine)

Laboratory Technician/Manager Position – MicroRNA Cancer Biology (Thomas Jefferson University)

Postdoctoral Position – Impact of Ubiquitin-Proteasome Pathway in Genome Stability and Breast Cancer (University of Pittsburgh)

Postdoctoral Position – Bioinformatics Position in Cancer Research (San Raffaele Scientific Institute)

Postdoctoral Research Assistant – Clonal Expansion and Progression of Ductal Carcinoma In Situ (Barts Cancer Institute)

Postdoctoral Position – Regulation of Gene Expression in Breast Cancer (University of Cincinnati)

Postdoctoral Research Assistant – Breast Cancer Campaign (University of Oxford)

PhD Student – Breast Cancer Biology (IDIBELL, Catalan Institute of Oncology)


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