Volume 4.38 | Sep 27

Mammary Cell News 4.38 September 27, 2012
Mammary Cell News
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LIFR Is a Breast Cancer Metastasis Suppressor Upstream of the Hippo-YES Associated Protein Pathway and a Prognostic Marker
Combining high-throughput RNA sequencing, functional characterization, mechanistic studies and clinical validation, investigators identified leukemia inhibitory factor receptor (LIFR) as a breast cancer metastasis suppressor downstream of the microRNA miR-9 and upstream of Hippo signaling. [Nat Med]
Abstract | Press Release

Use Aldefluor to Detect Breast Cancer Stem Cells - Click here to learn more
PUBLICATIONS (Ranked by impact factor of the journal)


Nicastrin Regulates Breast Cancer Stem Cell Properties and Tumor Growth In Vitro and In Vivo
Researchers used 2D and 3D Matrigel, anchorage-independent growth conditions and a breast cancer xenograft mouse model to assess the impact of nicastrin on breast cancer stem cell propagation and invasion in vitro and tumor growth in vivo. [Proc Natl Acad Sci USA] Abstract

Basal But Not Luminal Mammary Epithelial Cells Require PI3K/mTOR Signaling for Ras-Driven Overgrowth
Scientists found that blocking either the phosphoinositide 3-kinase (PI3K) or the mammalian target of rapamycin (mTOR) pathway completely suppressed Ras-driven invasion and overgrowth of basal mammary epithielial cells (MECs), but only modestly attenuated Ras-driven phenotypes in luminal MECs. [Cancer Res] Abstract

Neurotrophin-3 Modulates Breast Cancer Cells and the Microenvironment to Promote the Growth of Breast Cancer Brain Metastasis
Researchers showed that a protein from the brain metastatic protein signature, neurotrophin-3 (NT-3), has a dual function of regulating the metastatic growth of metastatic breast cancer cells and reducing the activation of immune response in the brain. Increased NT-3 secretion in metastatic breast cancer cells resulted in a reversion of mesenchymal-like state to epithelial-like state and vice versa. [Oncogene] Abstract

Orai3 Is an Estrogen Receptor α-Regulated Ca2+ Channel that Promotes Tumorigenesis
The authors recently described up-regulation of Orai3 channels that selectively mediate store-operated Ca2+ entry in estrogen receptor α-expressing (ERα+) breast cancer cells. In this report, they showed that ERα knockdown decreases Orai3 mRNA and protein with no effect on Orai1. [FASEB J] Abstract

NOTCH1 Inhibition In Vivo Results in Mammary Tumor Regression and Reduced Mammary Tumorsphere Forming Activity In Vitro
Researchers demonstrated that NOTCH1 transformed mouse mammary tumors harbor a rare mammary tumor initiating population and that NOTCH1 contributes to mammary tumor initiating activity. [Breast Cancer Res] Abstract

Inhibiting Aurora Kinases Reduces Tumor Growth and Suppresses Tumor Recurrence After Chemotherapy in Patient-Derived Triple-Negative Breast Cancer Xenografts
Researchers investigated the therapeutic potential of targeting Aurora kinases (AK) in preclinical models of human breast cancers, using a pan-inhibitor of
AK, AS703569. [Mol Cancer Ther] Abstract

Differential Regulation of Breast Cancer-Associated Genes by Progesterone Receptor Isoforms PRA and PRB in a New Bi-Inducible Breast Cancer Cell Line
To investigate the role of progesterone receptor (PR) isoforms (PRA and PRB) and the impact of imbalanced PRA/PRB ratio in transcriptional regulation, researchers generated an original human breast cancer cell line conditionally expressing PRA and/or PRB in dose-dependence of non-steroid inducers. [PLoS One]
Full Article


Diabetes and Breast Cancer Risk: A Meta-Analysis
The authors concluded that the risk of breast cancer in women with type 2 diabetes is increased by 27%, a figure that decreased to 16% after adjustment for body mass index. No increased risk was seen for women at pre-menopausal ages or with type 1 diabetes. [Br J Cancer] Abstract

CD133 Is a Useful Surrogate Marker for Predicting Chemosensitivity to Neoadjuvant Chemotherapy in Breast Cancer Researchers hypothesized that a cancer stem cell marker may identify neoadjuvant chemotherapy-resistant patients, and evaluated CD133 and ALDH1 as a potential surrogate marker for breast cancer. [PLoS One]
Full Article

Overexpression of Class III Beta Tubulin and Amplified HER2 Gene Predict Good Response to Paclitaxel and Trastuzumab Therapy
Clinicians aimed to validate several biomarkers that have been known to possibly predict the outcomes of trastuzumab and paclitaxel (TP). Human epidermal growth factor 2 (HER2) positive metastatic breast cancer patients who had been treated with TP in a single institute from 2006 to 2009 were included in this study. [PLoS One] Full Article

Don't Lose Sleep Over Mouse Mammary Tissue Dissociation (New Enzymes: Learn More)

When to Order a Biopsy to Characterise a Metastatic Relapse in Breast Cancer
The authors reviewed and discussed the currently available data and provided recommendations on when a metastatic biopsy should be obtained. [Ann Oncol] Full Article

Generex Biotechnology Announces Presentation of Early Results Showing Activity of Cancer Vaccine in Patients with Triple Negative Breast Cancer
Generex Biotechnology Corporation announced the presentation of early results from an efficacy study of an immunotherapeutic in triple negative breast cancer patients. The immunotherapeutic being developed by Antigen Express, Inc. is designed to generate an immune response specifically targeting tumor cells expressing the HER2 oncoprotein. [Generex Biotechnology] Press Release

Strand Diagnostics Launches the Know Error® System for Breast Biopsies
Strand Diagnostics, LLC, maker of the know error® system for prostate biopsies, today announced the launch of a new system designed to protect breast biopsy patients from inaccurate diagnosis due to misidentification of biopsy samples. [PR Newswire] Press Release

jcpenney Customers Invited to Join Company’s Support of the Breast Cancer Research Foundation®
This October, in honor of breast cancer awareness month, jcpenney customers can round up their store purchases to the nearest whole dollar and donate the difference to The Breast Cancer Research Foundation. [J. C. Penney Company Inc.] Press Release


ACLU Challenges Patents On Breast Cancer Genes: BRCA 
A lawsuit was filed against the U.S. Patent and Trademark Office, as well as Myriad Genetics and the University of Utah Research Foundation, which hold the patents on the genes, BRCA1 and BRCA2. The lawsuit charges that patents on human genes violate the First Amendment and patent law because genes are “products of nature” and therefore can’t be patented. [American Civil Liberties Union]
Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)


NEW Cancer Cell Metabolism and Systems Biology
December 6, 2012
New York, USA

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Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)

Assistant Professor – Breast Cancer Research (Johns Hopkins University)

Postdoctoral Position – Stem Cell/Cancer/Developmental Biology (Tufts University School of Medicine)

Postdoctoral Fellow – Gene Regulation in Breast Cancer/Stem Cell Biology (University of Cincinnati)

Associate Attending Breast Pathologist (Memorial Sloan-Kettering Cancer Center)

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