Volume 4.08 | Mar 1

Mammary Cell News 4.08 March 1, 2012
Mammary Cell News
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Scientists Uncover Inflammatory Circuit that Triggers Breast Cancer
Scientists have shed new light on exactly how the activation of a pair of inflammatory signaling pathways leads to the transformation of normal breast cells to cancer cells. [Press release from The Scripps Research Institute discussing online prepublication in Molecular Cell] Press Release | Abstract

Learn More: Column-Free Enrichment of Mouse Mammary Stem & Progenitor Cells
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Deleted in Colorectal Carcinoma (DCC) Suppresses Metastasis in p53-Deficient Mammary Tumors
Here scientists show that in a mouse model of mammary carcinoma based on somatic inactivation of p53, additional loss of DCC gene promotes metastasis formation without affecting the primary tumor phenotype. [Nature] Abstract

Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk
Here, investigators used pre-diagnostic blood samples from three studies to analyze white blood cell DNA methylation of two ATM intragenic loci (ATMmvp2a and ATMmvp2b) and genome-wide DNA methylation in LINE1 repetitive elements. [Cancer Res] Abstract

Conditional Activation of Pik3caH1047R in a Knock-In Mouse Model Promotes Mammary Tumorigenesis and Emergence of Mutations
In this study, researchers report the development of a knock-in mouse model for breast cancer where the endogenous Pik3ca allele was modified to allow tissue-specific conditional expression of a frequently found Pik3caH1047R mutant allele. [Oncogene] Abstract

cMET and Phospho-cMET Protein Levels in Breast Cancers and Survival Outcomes
The purpose of this study is to evaluate cMET and phospho-cMET levels in breast cancer subtypes and its impact on survival outcomes. [Clin Cancer Res] Abstract

A Whole-Genome Massively Parallel Sequencing Analysis of BRCA1 Mutant Estrogen Receptor-Negative and -Positive Breast Cancers
This study demonstrates that BRCA1 pathogenic germline mutations coupled with somatic loss of the wild-type allele are not sufficient for hereditary breast cancers to display an estrogen receptor-negative phenotype, and has led to the identification of three potential novel breast cancer genes (ie DAPK3, TMEM135, and GATA4). [J Pathol] Abstract

Focal Adhesion Kinase Contributes to Proliferative Potential of ErbB2 Mammary Tumor Cells But Is Dispensable for ErbB2 Mammary Tumor Induction In Vivo
To directly evaluate the role of Focal Adhesion Kinase (FAK) in mammary tumor progression, investigators have used a conditional FAK mouse model and MMTV-driven Cre recombinase strain to inactivate FAK in the mammary epithelium of a transgenic mouse model of ErbB2 breast cancer. [Breast Cancer Res] Abstract

Clinicopathological and Biological Significance of Human Voltage-Gated Proton Channel Hv1 Over-Expression in Breast Cancer
In this study, scientists showed that the voltage-gated proton channel Hv1 expression was significantly correlated with the tumor size (P = 0.001), tumor classification (P = 0.000), lymph node status (P = 0.000), clinical stage (P = 0.000) and Her-2 status (P = 0.045). [J Biol Chem] Abstract

Combination of Pan-Histone Deacetylase Inhibitor and Autophagy Inhibitor Exerts Superior Efficacy Against Triple-Negative Human Breast Cancer Cells
Here, researchers determined the in vitro and in vivo activity of the combination of the pan-histone deacetylase inhibitor panobinostat and the autophagy inhibitor chloroquine against human estrogen/progesterone receptor and HER2 (triple)-negative breast cancer cells. [Mol Cancer Ther] Abstract

Phenformin as Prophylaxis and Therapy in Breast Cancer Xenografts
Investigators sought to determine the efficacy of the biguanide phenformin in the chemoprophylaxis and in the treatment of estrogen receptor-positive MCF7 and receptor triple-negative MDAMB231 xenografts in immunocompromised mice. [Br J Cancer] Abstract


FACT: An Open-Label Randomized Phase III Study of Fulvestrant and Anastrozole in Combination Compared with Anastrozole Alone as First-Line Therapy for Patients with Receptor-Positive Postmenopausal Breast Cancer
The purpose of this study is to compare the effect of therapy with anastrozole versus a combination of fulvestrant and anastrozole in women in first relapse of endocrine-responsive breast cancer. [J Clin Oncol] Abstract

Breast Conserving Therapy Versus Mastectomy for Stage I-II Breast Cancer: 20 Year Follow-Up of the EORTC 10801 Phase III Randomized Trial
The EORTC 10801 trial compared breast-conserving therapy (BCT) with modified radical mastectomy (MRM) in patients with tumors 5 cm or smaller and axillary node negative or positive disease. Compared with BCT, MRM resulted in better local control, but did not affect overall survival or time to distant metastases. Scientists report 20-year follow-up results. [Lancet Oncol] Abstract

Listen Now: New Podcast on ALDH in Breast Cancer Treatment Response
ISSCR Honors Stem Cell Research Pioneer with Prestigious McEwen Award for Innovation
The International Society for Stem Cell Research (ISSCR) is pleased to announce the winner of the 2012 McEwen Award for Innovation. [International Society for Stem Cell Research] Press Release

QF Awards Top Stem Cell Researchers at International Conference
Research on preventing breast cancer recurrence, using organ regeneration to combat obesity-related diseases, and enabling vascular repair for patients suffering from cardiovascular disease received awards at the Qatar International Conference on Stem Cell Science and Policy. [Qatar Foundation (QF)] Press Release

MOLOGEN AG Also Wins Patent Protection in Japan for Cell-Based Cancer Therapy MGN1601
The Japan Patent Office has announced its decision to grant a patent to the biotechnology company MOLOGEN AG for its invention of an “allogeneic tumor therapy”. [MOLOGEN AG] Press Release

Hoag Expands World-Class Breast Center with Opening of Satellite Center in Irvine
Hoag Memorial Hospital Presbyterian has expanded its world-class breast center in Newport Beach with the opening of a satellite center in the Woodbridge community of Irvine, further enhancing its status as the largest and most state-of-the-art facility of its kind in Southern California. [PRWeb] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW American Association for Cancer Research 103rd Annual Meeting 2012
March 31-April 4, 2012
Chicago, United States

NEW International Society for Cell & Gene Therapy of Cancer – 2012 Singapore Conference
October 5-6, 2012
Singapore, Singapore

Visit our events page to see a complete list of events in the mammary cell community.
Scientist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies Inc.)

Research Technologist (STEMCELL Technologies Inc.)

Business Analyst – Product Management (STEMSOFT Software Inc.)

Tenure Track Position (Johns Hopkins University)

Research Associate (Imperial College London)

Postdoctoral Fellow, Cancer Biology (North Carolina Central University)

Postdoctoral Fellow and Technician Positions (North Carolina Central University)

Postdoctoral Research Scientist (The Beatson Institute for Cancer Research) 

Associate Professor – Breast Pathology (Tianjin Medical University Cancer Institute and Hospital) 

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