Volume 4.01 | Jan 12

Mammary Cell News 4.01 January 12, 2012
Mammary Cell News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Breast Tumor Kinase/Protein-Tyrosine Kinase 6 Sustains Activated EGFR Signaling through Inhibiting EGFR Degradation and Transactivating EGFR
Epidermal growth factor receptor (EGFR)-mediated cell signaling is critical for mammary epithelial cell growth and survival; however, targeting EGFR has shown no or only minimal therapeutic benefit in patients with breast cancer. Here, researchers report a novel regulatory mechanism of EGFR signaling that may explain the low response rates. [Oncogene] Abstract

Listen Now: New Podcast on ALDH in Breast Cancer Treatment Response
PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Direct Regulation of MicroRNA Biogenesis and Expression by Estrogen Receptor ß in Hormone-Responsive Breast Cancer
Considering the possibility that estrogen receptor ß (ERß) might influence breast cancer (BC) cell behavior via microRNAs (miRNAs), researchers compared miRNome expression in ERß+ vs ERß- hormone-responsive BC cells and found a widespread effect of this ER subtype on the expression pattern of these non-coding RNAs. [Oncogene] Abstract

Hyperinsulinemia Enhances c-Myc-Mediated Mammary Tumor Development and Advances Metastatic Progression to the Lung in a Mouse Model of Type II Diabetes
Using a hyperinsulinemic mouse model and the metastatic, c-Myc-transformed mammary carcinoma cell line Mvt1, researchers investigated how high systemic insulin levels would affect the progression of orthotopically inoculated primary mammary tumors to lung metastases. [Breast Cancer Res] Abstract

Hypoxia Inducible Factor-1α Promotes Primary Tumor Growth and Tumor-Initiating Cell Activity in Breast Cancer
Researchers investigated whether hypoxia inducible factor-1α is directly implicated in regulation of tumor-initiating cells in breast cancer. [Breast Cancer Res] Abstract

Microcalcifications in Breast Cancer: Novel Insights into the Molecular Mechanism and Functional Consequence of Mammary Mineralization
Researchers report a novel model to investigate the in vitro mineralization potential of a panel of mammary cell lines. [Br J Cancer] Abstract

Impaired CK1δ Activity Attenuates SV40-Induced Cellular Transformation In Vitro and Mouse Mammary Carcinogenesis In Vivo
Here researchers characterized the effects of mutant CK1δ variants with impaired kinase activity on simian virus 40 (SV40)-induced cell transformation in vitro, and on SV40-induced mammary carcinogenesis in vivo in a transgenic/bi-transgenic mouse model. [PLoS One] Abstract

Small Interfering RNA Targeted to IGF-IR Delays Tumor Growth and Induces Proinflammatory Cytokines in a Mouse Breast Cancer Model
The aim of this study was to determine whether an RNA interference approach targeted to insulin-like growth factor-1 receptor (IGF-IR) could be used for specific antitumor immunostimulation in a breast cancer model. [PLoS One] Abstract

Bone Morphogenetic Protein (BMP) Signaling Regulates Mitotic Checkpoint Protein Levels in Human Breast Cancer Cells
In the present study researchers show that, in human breast cancer cells, chemical inhibition of BMPs, but not transforming growth factor-β, abrogates the mitotic arrest induced by nocodazole. [Cell Signal] Abstract

EphrinA1-EphA2 Interaction-Mediated Apoptosis and FMS-Like Tyrosine Kinase Receptor Ligand-Induced Immunotherapy Inhibits Tumor Growth in a Breast Cancer Mouse Model
Researchers tested the EphrinA1-EphA2 interaction in MDA-MB-231 breast cancer cells focusing on the receptor-ligand-mediated apoptosis of breast cancer cells. [J Gene Med] Abstract

CLINICAL RESEARCH

Estrogen Metabolism and Risk of Breast Cancer in Postmenopausal Women
In this study, researchers found nearly all estrogens, estrogen metabolites, and metabolic pathway groups were associated with an increased risk of breast cancer; the serum concentration of unconjugated estradiol was strongly associated with the risk of breast cancer. [J Natl Cancer Inst] Abstract

Novel Genetic Markers of Breast Cancer Survival Identified by a Genome-Wide Association Study
Here researchers report the identification of two SNPs associated with total mortality from a two-stage genome-wide association study conducted among 6,110 Shanghai-resident Chinese women with TNM stage I-IV breast cancer. [Cancer Res] Abstract

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INDUSTRY NEWS

Galena Biopharma Announces Investigational New Drug Approval for Phase II Trial for NeuVaxTM (E75 + Granulocyte Macrophage Colony-Stimulating Factor) Combined with Herceptin® (Trastuzumab)
Galena Biopharma announced that the U.S. Food and Drug Administration has been approved the Investigational New Drug application for the Phase II combination trial with NeuVax™ and Herceptin®. [Galena Biopharma] Press Release

Eisai Inc. Receives J-Code from CMS for Halaven® (Eribulin Mesylate) Injection
Eisai Inc. announced that the Centers for Medicare and Medicaid Services (CMS) has assigned a unique, permanent Healthcare Common Procedure Coding System J-code for Halaven® Injection. [Business Wire] Press Release


UND Signs License to Develop Breakthrough Breast Cancer Detection Technology with Neomatrix, LLC
The University of North Dakota (UND) and Neomatrix, LLC announced that they have signed an exclusive agreement to develop technology for the early detection of breast cancer using the company’s HALO® Breast Pap Test device. [The University of North Dakota School of Medicine & Health Sciences]
Press Release

Midatech Secures £6.3 Million Financing to Strengthen Product Development Portfolio
Midatech Ltd. announced it has raised £6.3 million through a private investment round. This financing will be used to support clinical development of chemotherapeutic gold nanoparticles designed to target ovarian, lung and breast carcinoma. [Midatech Ltd.] Press Release

OncoMed Pharmaceuticals Promotes Dr. Jakob Dupont to Chief Medical Officer
OncoMed Pharmaceuticals, Inc. announced the promotion of Jakob Dupont, M.D., formerly Vice President, Clinical Research, to Senior Vice President and Chief Medical Officer. [OncoMed Pharmaceuticals, Inc.] Press Release

AMGA Welcomes Four New Members to Board of Directors
The American Medical Group Association (AMGA) announced the addition of four new members to its Board of Directors. [American Medical Group Association] Press Release

POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW Gordon Research Conferences – Mammary Gland Biology
June 10-15, 2012
Lucca, Italy

NEW 28th International Association for Breast Cancer Research/Breakthrough Breast Cancer Conference
April 15-18, 2012
Manchester, United Kingdom

Visit our events page to see a complete list of events in the mammary cell community.

JOB OPPORTUNITIES
Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies, Inc.)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Fellow (University of Alberta)

Postdoctoral Positions (Cancer Science Institute of Singapore)

Research Postdoctoral Fellow (Institut Curie UMR 144)

Postdoctoral Position for Translational Bioinformatics in Cancer Research (Baylor College of Medicine)


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