Volume 4.00 | Jan 5

Mammary Cell News 4.00 January 5, 2012
Mammary Cell News
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs
Cell Therapy News on Facebook  Mammary Cell News on Twitter
TOP STORY
Reprogrammed Estrogen Binding Linked to More Aggressive Breast Cancer
Scientists have discovered how receptors for estrogen attach to a different part of the DNA in breast cancer patients who are more likely to relapse. [Press release from Cancer Research UK discussing online prepublication in Nature] Press Release | Abstract

Listen Now: New Podcast on ALDH in Breast Cancer Treatment Response
PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH

Mechanical Compression Drives Cancer Cells Toward Invasive Phenotype
Here researchers show that compressive stress stimulates migration of mammary carcinoma cells. [Proc Natl Acad Sci USA] Abstract

CD146, an Epithelial-Mesenchymal Transition Inducer, Is Associated with Triple-Negative Breast Cancer
Here, investigators report that CD146 is a unique activator of epithelial-mesenchymal transitions and significantly correlates with triple-negative breast cancer. [Proc Natl Acad Sci USA] Abstract

EGR1 and the ERK-ERF Axis Drive Mammary Cell Migration in Response to Epidermal Growth Factor
Researchers demonstrate that induction of early growth response-1 (EGR1) involves ERK-mediated down-regulation of microRNA-191 and phosphorylation of the ETS2 repressor factor (ERF) repressor, which subsequently leaves the nucleus. [FASEB J] Abstract

ER-α Signaling Imparts Chemotherapeutic Selectivity to Selenium Nanoparticles in Breast Cancer
The present study focuses on the synthesis of stable selenium nanoparticles and to elucidate their mechanism of action in preventing the growth of mammary tumors. [Nanomedicine] Abstract

Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of HIF-1 and RNA-Binding Protein HuR
Here scientists report that Hsf1 knockout suppressed mammary hyperplasia in Her2-expressing mice and reduced tumor emergence. [Mol Cell Biol] Abstract

Repression of Mammosphere Formation of Human Breast Cancer Cells by Soy Isoflavone Genistein and Blueberry Polyphenolic Acids Suggests Diet-Mediated Targeting of Cancer Stem-Like/Progenitor Cells
Here, researchers addressed whether dietary factors selectively target mammary epithelial cells that display stem-like/progenitor subpopulations with previously recognized tumor-initiating potential. [Carcinogenesis] Abstract

Mechanism of MTA1 Overexpression-Linked Invasion: MTA1 Regulation of HMMR Expression and Function
Here investigators found for the first time that metastatic tumor antigen 1 (MTA1), a master chromatin modifier, regulates the expression of Hyaluronic-Mediated Motility Receptor (HMMR) and consequently, its function in breast cancer cells’ motility and invasiveness. [J Biol Chem] Abstract

Loss of Hypermethylated In Cancer 1 (HIC1) in Breast Cancer Cells Contributes to Stress Induced Migration and Invasion through β-2 Adrenergic Receptor (ADRB2) Misregulation
Through promoter luciferase activity, Chromatin Immunoprecipitation (ChIP) and sequential ChIP experiments, scientists demonstrate that ADRB2 is a direct target gene of HIC1, endogenously in WI-38 cells and following HIC1 re-expression in breast cancer cells. [J Biol Chem] Abstract

DNA Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer
Researchers examined the effect of zebularine on mammary tumor growth in genetically engineered MMTV-PyMT transgenic mice that develop mammary tumors at 60 days of age with 100 percent penetrance. [Mol Cancer Ther] Abstract

Overexpression of 5-Lipoxygenase and Its Relation with Cell Proliferation and Angiogenesis in 7,12-Dimethylbenz(α)Anthracene-Induced Rat Mammary Carcinogenesis
The present study was performed to investigate the critical role of 5-lipoxygenase in 7,12-dimethylbenz(α)anthracene-induced rat mammary inflammation-associated carcinogenesis. [Mol Carcinog] Abstract

ISG15 Disrupts Cytoskeletal Architecture and Promotes Motility in Human Breast Cancer Cells
Using the gene disruption approach, investigators demonstrate that both interferon-stimulated gene 15 (ISG15) and UbcH8 (ISG15-specific conjugating enzyme) disrupt F-actin architecture and formation of focal adhesions in ZR-75-1 breast cancer cells. [Exp Biol Med] Abstract | Press Release

CLINICAL RESEARCH

Multicentric/Multifocal Breast Cancer with a Single Histotype: Is the Biological Characterization of All Individual Foci Justified?
Invasive multiple breast cancers with a single histological feature showed heterogeneity among foci. In the clinical practice, such assessment led to 14 (12.4%) patients receiving different adjuvant treatments compared with what would have been indicated if researchers had only taken into account the biologic status of the primary tumor. [Ann Oncol] Abstract

Long-Term Prognosis of Breast Cancer Detected by Mammography Screening or Other Methods
The purpose of the current study was to compare breast cancer-specific long-term survival between patients whose tumors were detected in mammography screening and those detected by other methods. [Breast Cancer Res] Abstract

Free Wallchart | Assays for Human Mammary Stem and Progenitor Cells
SCIENCE NEWS
Researchers Present Findings from Kentucky Breast Cancer Patients with Disease Relapse
Dr. Suleiman Massarweh and his research team presented findings from their studies on relapse of breast cancer. The two studies aimed to characterize further risk factors for presentation with metastatic disease or risk of early metastatic relapse after initial therapy. [Press release from the University of Kentucky discussing research presented at the San Antonio Breast Cancer Symposium, San Antonio] Press Release
INDUSTRY NEWS
Georgetown Pharmacologist V. Craig Jordan to Receive 2012 ASPET Goodman & Gilman Award
V. Craig Jordan has been selected as the recipient of the 2012 ASPET Goodman and Gillman Award in Drug Receptor Pharmacology by the American Society for Pharmacology and Experimental Therapeutics (ASPET). [Lombardi Comprehensive Cancer Center] Press Release

Generex Subsidiary Antigen Express Provides Update on AE37 Cancer Vaccine’s Clinical and Regulatory Strategy
Generex Biotechnology Corporation provided an update to the clinical development and regulatory strategy for its cancer vaccine, AE37. [Generex Biotechnology Corporation] Press Release

UK Experimental Cancer Trials Network Granted £35 Million Funding Boost
The Experimental Cancer Medicine Centres Network, which runs UK clinical studies of the newest cancer treatments, has been awarded a second wave of £35 million funding for the next five years. [Cancer Research UK] Press Release

Cellular-Imaging Center Gets Over $8 Million to Speed Search for Earlier Diagnostic Tests and Treatments for Cancer
A team of cancer imaging experts at Johns Hopkins has embarked on a five-year research initiative to speed development of early diagnostic tests and new treatments for breast, prostate and other common cancers. [Johns Hopkins University School of Medicine] Press Release
POLICY NEWS
Oncologic Drugs Advisory Committee; Notice of Meeting [FR Doc No: 2011-33548] [Food and Drug Administration, United States]

Oncologic Drugs Advisory Committee; Notice of Meeting [FR Doc No: 2011-33552] [Food and Drug Administration, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW Select Biosciences – Circulating Tumor Cells 2012
February 2-3, 2012
San Diego, United States

NEW 8th Annual Swiss Stem Cell Network Meeting
February 10, 2012
Zurich, Switzerland

NEW Keystone Symposia on Molecular and Cellular Biology: Cancer and Metabolism
February 12-17, 2012
Banff, Canada

NEW European Association for Cancer Research Congress
July 7-10, 2012
Barcelona, Spain

Visit
our events page to see a complete list of events in the mammary cell community.
JOB OPPORTUNITIES
Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies, Inc.)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Fellow (University of Alberta)

Postdoctoral Positions (Cancer Science Institute of Singapore)

Postdoctoral Researcher (Institute for Molecular Medicine Finland)

Research Postdoctoral Fellow (Institut Curie UMR 144)

Postdoctoral Position for Translational Bioinformatics in Cancer Research (Baylor College of Medicine)


Recruit Top Talent

Reach more than 11,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Jobs are categorized regionally: United States, Canada, Europe,
Asia Pacific

Visit here to post your career opportunities.

Have we missed an important article or publication in Mammary Cell News? Click here to submit!

Comments or Suggestions? Email [email protected] with your feedback.

Learn more about Mammary Cell News: Archives | Events | Contact Us