Volume 3.42 | Oct 27

Mammary Cell News 3.42, October 27, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Tumor Grafts Derived from Women with Breast Cancer Authentically Reflect Tumor Pathology, Growth, Metastasis and Disease Outcomes
Researchers report new models for breast tumor growth and metastasis in the form of transplantable tumors derived directly from individuals undergoing treatment for breast cancer. [Nat Med] Abstract | Press Release

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PUBLICATIONS (Ranked by Impact Factor of the Journal)
LABORATORY RESEARCH

Estrogen Induces Apoptosis in Estrogen Deprivation-Resistant Breast Cancer through Stress Responses As Identified by Global Gene Expression Across Time
Scientists interrogated 17β-estradiol (E2)-induced apoptosis by analysis of gene expression across time (2–96 hours) in MCF-7 cell variants that were estrogen-dependent or resistant to estrogen deprivation and refractory or sensitive to E2-induced apoptosis. [Proc Natl Acad Sci USA] Abstract

Selectin Ligand Sialyl-Lewis X Antigen Drives Metastasis of Hormone-Dependent Breast Cancers
Investigators found that genes involved in the synthesis of sialyl-Lewis x (FUT3, FUT4 and ST3GAL6) are significantly increased in estrogen receptor (ER) alpha negative tumors compared to ER-positive ones. [Cancer Res] Abstract


TGFβ1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo
The purpose of this study is to determine whether inhibition of TGFβ signaling prior to irradiation sensitizes human and murine cancer cells in vitro and in vivo. [Clin Cancer Res] Abstract


TIEG1 Inhibits Breast Cancer Invasion and Metastasis by Inhibition of EGFR Transcription and the EGFR Signaling Pathway
In this study, scientists find that decreased TIEG1 expression is associated with increased EGFR expression in breast cancer tissues and cell lines. [Mol Cell Biol] Abstract


CLINICAL RESEARCH

Assessment of Letrozole and Tamoxifen Alone and In Sequence for Postmenopausal Women with Steroid Hormone Receptor-Positive Breast Cancer: The BIG 1-98 Randomized Clinical Trial at 8·1 Years Median Follow-Up
Investigators present an update of efficacy outcomes in the Breast International Group (BIG) 1-98 study at 8·1 years median follow-up. [Lancet Oncol] Abstract | Press Release

Capecitabine Versus Classical Cyclophosphamide, Methotrexate, and Fluorouracil As First-Line Chemotherapy for Advanced Breast Cancer
Scientists compared oral capecitabine, administered intermittently or continuously, versus classical cyclophosphamide, methotrexate, and fluorouracil as first-line chemotherapy for women with advanced breast cancer unsuited to more intensive regimens. [J Clin Oncol] Abstract


Dasatinib as a Single Agent in Triple-Negative Breast Cancer: Results of an Open-Label Phase II Study
This phase II trial assessed efficacy and safety of single-agent dasatinib in patients with advanced triple-negative breast cancer. [Clin Cancer Res] Abstract


The Combined Influence of Multiple Sex and Growth Hormones on Risk of Postmenopausal Breast Cancer: A Nested Case-Control Study
Investigators considered the role of estrone, estradiol, estrone sulfate, testosterone, androstenedione, dehydroepiandrosterone (DHEA), DHEA sulfate, and prolactin, and secondarily insulin-like growth factor and c-peptide, in postmenopausal breast cancer risk, among 265 cases and 541 controls in the prospective Nurses’ Health Study. [Breast Cancer Res] Abstract | Press Release

Preclinical and Clinical Evaluation of Intraductally Administered Agents in Early Breast Cancer
Researchers performed preclinical studies in N-methyl-N′-nitrosourea–treated rats to compare the effects of 5-fluorouracil, carboplatin, nanoparticle albumin-bound paclitaxel, and methotrexate to the previously reported efficacy of pegylated liposomal doxorubicin (PLD) on treatment of early and established mammary tumors. Concurrently, they initiated a clinical trial to establish the feasibility, safety, and maximum tolerated dose of intraductal PLD. [Sci Transl Med] Abstract | Press Release


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INDUSTRY NEWS
Dana-Farber, Brigham and Women’s Launch Profile, a Large-Scale Research Program to Scan Tumors for Mutations, Establish Extensive Genomic Database
Committed to speeding the development of cancer treatments that target the genetic weaknesses in each patient’s tumor, Dana-Farber Cancer Institute and Brigham and Women’s Hospital have launched Profile, a major effort to scan tumor tissue from adult cancer patients for hundreds of gene mutations linked to cancer. [Dana-Farber Cancer Institute] Press Release


Ohio State Dedicates Comprehensive Breast Center in Honor of Stefanie Spielman
The Ohio State University President E. Gordon Gee announced the naming of The Stefanie Spielman Comprehensive Breast Center, in honor of the Ohio State alumna, philanthropist and advocate. [The James Comprehensive Cancer Center] Press Release


Cracking Breast Cancer’s Genetic Code May Lead to New Treatments
Michigan State University’s Eran Andrechek, an assistant professor in the Department of Physiology, has received a $450,000 grant from the Susan G. Komen for the Cure foundation to better understand the differences both within and between breast cancers. [Michigan State University] Press Release


Sheffield Launches New Cancer Research Center
Cancer Research UK and Yorkshire Cancer Research have come together for the first time to fund a new cancer research center in Sheffield. [Cancer Research UK] Press Release
POLICY NEWS
Breast Cancer Screening: An Independent Review Is Under Way
A review of the evidence underpinning breast screening was announced by Professor Sir Mike Richards (National Cancer Director) in a letter to the British Medical Journal. [National Health Service, United Kingdom] Press Release


National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS
NEW BIT’s 4th Annual World Cancer Congress 2011 – Breast Cancer Conference
November 16-18, 2011
Guangzhou, China

NEW Stem Cell Society Singapore Symposium 2011
November 17-18, 2011
Singapore

Visit
our events page to see a complete list of events in the mammary cell community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Postdoctoral Fellow in Breast Cancer (Indiana University School of Medicine)

Research Fellow in Breast Cancer Research (Monash University)

Postdoctoral Fellow in Breast Cancer (Indiana University School of Medicine)

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