Volume 3.39 | Oct 6

Mammary Cell News 3.39, October 6, 2011
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY

c-MYC Functions as a Molecular Switch to Alter the Response of Human Mammary Epithelial Cells to Oncostatin M
Using isogenic human mammary epithelial cells at different stages of neoplastic transformation, investigators found that oncostatin M signaling suppressed c-MYC expression and engaged a p16- and p53-independent growth arrest that required STAT3 activity. [Cancer Res] Abstract


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PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Intersection of FOXO- and RUNX1-Mediated Gene Expression Programs in Single Breast Epithelial Cells During Morphogenesis and Tumor Progression
Here, scientists adapted a single-cell expression profiling technique to examine the gene expression program downstream of Forkhead box O (FOXO) transcription factors during 3D breast epithelial acinar morphogenesis. [Proc Natl Acad Sci USA] Abstract


Maintenance of Hormone Responsiveness in Luminal Breast Cancers by Suppression of Notch
Here researchers show that more than half of primary estrogen positive (ER+) and progesterone positive (PR+) breast cancers contain an ERPRcytokeratin+ “luminobasal” subpopulation exceeding 1% of cells. [Proc Natl Acad Sci USA] Abstract


Transglutaminase 2 Facilitates the Distant Hematogenous Metastasis of Breast Cancer by Modulating Interleukin-6 in Cancer Cells
The purpose of this study is to investigate the role for transglutaminase 2 (TG2) and interleukin (IL)-6, TG2-knocked-down and IL-6-knocked-down cancer cells were generated using shRNA. [Breast Cancer Res] Abstract


Genomic and Phenotypic Analysis of BRCA2 Mutated Breast Cancers Reveals Co-Occurring Changes Linked to Progression
Here scientists explore the impact of DNA copy number changes in BRCA2 tumors with respect to phenotype and clinical staging of the disease. [Breast Cancer Res] Abstract


Jumonji/Arid1 B (JARID1B) Promotes Breast Tumor Cell Cycle Progression through Epigenetic Repression of MicroRNA Let-7e
Here researchers investigated the influence of the histone demethylase JARID1B on microRNA regulation in breast tumor cells. [J Biol Chem] Abstract


Loss of Tumor Suppressor Merlin in Advanced Breast Cancer Is Due to Post-Translational Regulation
Investigators assessed Merlin expression in breast cancer tissues by immunohistochemistry and by real-time PCR. [J Biol Chem] Abstract

Combination Therapy Inhibits Development and Progression of Mammary Tumors in Immunocompetent Mice
Investigators have determined the effect of combining the chemotherapy agent doxorubicin and the anti-resorptive drug zoledronic acid on the early stages of spontaneous mammary tumor development using the immunocompetent PyMT mouse model that closely mimics human breast cancer development. [Breast Cancer Res Treat] Abstract

CLINICAL RESEARCH

Adjuvant Trastuzumab in HER2-Positive Breast Cancer
Scientists randomly assigned 3222 women with HER2-positive early-stage breast cancer to receive doxorubicin and cyclophosphamide followed by docetaxel every 3 weeks, the same regimen plus 52 weeks of trastuzumab, or docetaxel and carboplatin plus 52 weeks of trastuzumab. [N Eng J Med] Abstract | Press Release

Cytokeratin-19 and Mammaglobin Gene Expression in Circulating Tumor Cells from Metastatic Breast Cancer Patients Enrolled in North Central Cancer Treatment Group Trials (NCCTG), N0234/336/436/437
The purpose of this study is to investigate the associations between baseline and post-treatment circulating tumor cell gene expression and outcome of patients enrolled in four NCCTG metastatic breast cancer trials where specimens were shipped (at 4°C) from community-based sites to a reference laboratory. [Clin Cancer Res] Abstract


Family History of Breast Cancer in Relation to Tumor Characteristics and Mortality in a Population-Based Study of Young Women with Invasive Breast Cancer
Within a population-based cohort of 1260 non-adopted women diagnosed with invasive breast cancer before age 46, researchers assessed how family history of breast cancer relates to mortality and tumor characteristics. [Cancer Epidemiol Biomarkers Prev] Abstract

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SCIENCE NEWS
Beta-Blockers Could Stop Breast Cancer Spreading
Cancer Research UK scientists are investigating whether beta-blockers hold the key to preventing breast cancer spread and improving survival. [Press release from Cancer Research UK discussing research presented at the Royal Society of Medicine, London] Press Release
INDUSTRY NEWS

Tracking Breast Cancer Over Decades to Save Lives
A new way to study and treat breast cancer being launched at the University of California, San Francisco in October will screen women for the disease and provide them with individual assessments of their risk of developing the cancer. [University of California, San Francisco] Press Release


$6.5 Million Study Targets High Breast Cancer Deaths in Black Women
African American women have lower breast cancer survival rates than white women and University of California, San Francisco scientists are studying why – as well as how to increase their life spans. [University of California, San Francisco] Press Release

Top Honors for Dr. Armando E. Giuliano of Cedars-Sinai from One of the World’s Leading Breast Cancer Groups
One of the world’s leading breast cancer organizations has bestowed its highest honors on Armando E. Giuliano, MD, a renowned breast cancer surgeon at Cedars-Sinai Medical Center whose 30-year research career has resulted in major advances in the compassionate care for and quality of life of women with breast cancer. [Cedars-Sinai Medical Center] Press Release

POLICY NEWS

Blue Shield of California Statement Regarding Changes to Coverage Policy for Avastin
Blue Shield of California has announced that their coverage policy for Avastin for advanced breast cancer will be changed, effective October 17, 2011. [Blue Shield of California, United States] Press Release


New NICE Quality Standard Published on Breast Cancer
The National Institute of Clinical Excellence (NICE) has published a new quality standard on breast cancer for use in all National Health Service-funded settings in England. [National Institute of Clinical Excellence, United Kingdom] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

EVENTS

NEW The Australasian Society of Stem Cell Research 4th Annual Conference
October 23-25, 2011
Leura, Australia

Visit
our events page to see a complete list of events in the mammary cell community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Postdoctoral Fellow in Breast Cancer (Indiana University School of Medicine)

Research Fellow in Breast Cancer Research (Monash University)

Postdoctoral Fellow in Breast Cancer (Indiana University School of Medicine)

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