Volume 3.37 | Sep 22

Mammary Cell News 3.37, September 22, 2011
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
Cellular Origin of a Rare Form of Breast Cancer Identified
New research has determined that common forms of breast cancer originate from breast cells known as luminal epithelial cells while rarer forms of breast cancer, such as metaplastic carcinomas, originate from basal epithelial cell types. [Press release from Tufts University School of Medicine discussing online prepublication in the Proceedings of the National Academy of Sciences USA] Press Release | Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Binding of the JmjC Demethylase JARID1B to LSD1/NuRD Suppresses Angiogenesis and Metastasis in Breast Cancer Cells by Repressing Chemokine CCL14
In this study, investigators report that JARID1B is a physical component of the LSD1/NuRD complex that functions in transcriptional repression. [Cancer Res] Abstract


Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK-Cells Recognition
Scientists studied whether breast cancer subtypes might have different susceptibility to NK-cells anti-tumor immunity. [Cancer Res] Abstract


The New Truncated Somatostatin Receptor Variant sst5TMD4 Is Associated to Poor Prognosis in Breast Cancer and Increases Malignancy in MCF-7 Cells
Here, scientists investigated the possible role of sst5TMD4 in breast cancer. [Oncogene] Abstract


Gadolinium Metallofullerenol Nanoparticle Inhibits Cancer Metastasis through Matrix Metalloproteinase Inhibition: Prison Instead of Poison Cancer Cells
The purpose of this work is to study the anti-metastasis activity of [email protected]82(OH)22 metallofullerenol nanoparticles in malignant and invasive human breast cancer models. [Nanomedicine] Abstract


Suppression of Apoptosis Inhibitor c-FLIP Selectively Eliminates Breast Cancer Stem Cell Activity in Response to the Anti-Cancer Agent, TRAIL
In order to identify strategies to selectively remove breast cancer stem cells (bCSCs) from breast cancers, irrespective of their clinical subtype, investigators sought an apoptosis mechanism that would target bCSCs yet would not kill normal cells. [Breast Cancer Res] Abstract


CDDO-Methyl Ester Delays Breast Cancer Development in BRCA1-Mutated Mice
Because the methyl ester of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me) is a potent chemopreventive agent, researchers tested its efficacy in a highly relevant mouse model of BRCA1-mutated breast cancer. [Cancer Prev Res] Abstract


Neuropeptide Y Stimulates Proliferation and Migration in the 4T1 Breast Cancer Cell Line
The specific aims of the current study were to characterize norepinephrine and neuropeptide Y (NPY) receptor expression in 4T1 breast cancer cells and orthotopic tumors grown in BALB/c mice and investigate the impact of NPY receptor activation on 4T1 cell proliferation and migration in vitro. [Int J Cancer] Abstract | Press Release

Differential Turnover of Myosin Chaperone UNC-45A Isoforms Increases in Metastatic Human Breast Cancer
Here, investigators show that UNC-45A mRNA and protein expression was elevated in human breast carcinomas and cell lines derived from breast carcinoma metastases. [J Mol Biol] Abstract | Press Release

Alcohol Metabolism in Human Cells Causes DNA Damage and Activates the Fanconi Anemia–Breast Cancer Susceptibility (FA-BRCA) DNA Damage Response Network
To determine whether intracellular generation of acetaldehyde from ethanol metabolism can cause DNA damage and activate the FA-BRCA network, scientists engineered HeLa cells to metabolize alcohol by expression of human alcohol dehydrogenase 1B. [Alcohol Clin Exp Res] Abstract | Press Release

CLINICAL RESEARCH

Relationship Between Quantitative GRB7 RNA Expression and Recurrence After Adjuvant Anthracycline Chemotherapy in Triple Negative Breast Cancer
The purpose of this study is to perform an exploratory analysis of the relationship between gene expression and recurrence in patients with operable triple negative breast cancer treated with adjuvant doxorubicin-containing chemotherapy. [Clin Cancer Res] Abstract


MutYH Mutation Carriers Have Increased Breast Cancer Risk
The authors studied the risk of breast cancer associated with MutYH variants in a unique ethnic group of Sephardi Jews in Israel with a high prevalence of MutYH mutations. [Cancer] Abstract

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SCIENCE NEWS

Association Found Between Stress and Breast Cancer Aggressiveness
Psychosocial stress could play a role in the etiology of breast cancer aggressiveness, particularly among minority populations, according to study results. [Press Release from the American Association for Cancer Research (AACR) discussing research presented at the 4th AACR Conference on The Science of Cancer Health Disparities, Washington] Press Release


Higher Incidence of Secondary Breast Cancer Seen Among Black Women Regardless of Age
The overall incidence of breast cancer is generally higher among white women than black women; however, the incidence of a second breast cancer in the opposite breast is higher among black women, according to a study. [Press Release from the American Association for Cancer Research (AACR) discussing research presented at the 4th AACR Conference on The Science of Cancer Health Disparities, Washington] Press Release


Test Could Detect Breast Cancers Earlier in Young, High-Risk African-American Women
Certain cancer signaling pathways that are activated in aggressive cancer can be detected very early, even in precancerous cells, among young African-American women at high risk for breast cancer. [Press Release from the American Association for Cancer Research (AACR) discussing research presented at the 4th AACR Conference on The Science of Cancer Health Disparities, Washington] Press Release


Researchers Design Cancer Treatment to Safely Target All Solid Tumors
A new cancer treatment being developed at the University of Bradford has the potential to find and completely destroy solid tumors, regardless of cancer type. [University of Bradford] Press Release

INDUSTRY NEWS

GE and Partners Aim to Speed Fight Against Cancer, Starting with Breast Cancer
General Electric Company (GE) and leading healthcare and financial partners launched a new healthymagination initiative aimed at accelerating cancer innovation and improving care for 10 million cancer patients around the world by 2020. [General Electric Company] Press Release

U-M Gets $3.5 Million Grant to Study Breast Cancer Stem Cells and Racial Disparities
Researchers at the University of Michigan (U-M) Comprehensive Cancer Center have been awarded a $3.5 million grant from Susan G. Komen for the Cure to study cancer stem cells in an aggressive subtype of breast cancer that disproportionately affects African-Americans. [University of Michigan Health System] Press Release

Three U-M Researchers Named 2011 MacArthur Fellows
Three University of Michigan (U-M) researchers—a historian, a chemist and a stem cell biologist—are among the 22 new MacArthur Fellows announced by the John D. and Catherine T. MacArthur Foundation. [University of Michigan] Press Release

POLICY NEWS
AACR Releases Landmark Cancer Progress Report
The American Association for Cancer Research (AACR) unveiled the AACR Cancer Progress Report 2011 during a press conference at the National Press Club in Washington, D.C. [American Association for Cancer Research] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
EVENTS

NEW 1st Annual Congress on Stem Cell Research
September 28-October 2, 2011
Sapanca, Turkey

Visit our events page to see a complete list of events in the mammary cell community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist (STEMCELL Technologies)

Academic Surgical Pathologist / Breast Pathology (The University of Texas Health Science Center at San Antonio)

Post-Doctoral Position (Michigan State University)

Post-Doctoral Scientists (North Carolina Central University)

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