Volume 3.04 | Feb 3

Mammary Cell News 3.04 February 3, 2011.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Scientists Discover Mechanism Involved in Breast Cancer’s Spread to Bone  ShareThis
In a discovery that may lead to a new treatment for breast cancer that has spread to the bone, a research team has unraveled a mystery about how these tumors take root. [Press release from Princeton University discussing online prepublication in Cancer Cell]

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SCIENCE NEWS

Microbubble Contrast-Enhanced Ultrasound May Reduce Number of Breast Cancer Surgeries
Using “microbubbles” and ultrasound can mean more targeted breast biopsies for patients with early breast cancer, helping to determine treatment and possibly saving those patients from undergoing a second breast cancer surgery, a new study shows. [Press release from the American Roentgen Ray Society discussing online prepublication in the American Journal of Roentgenology]

Painful Hip Fractures Strike Breast Cancer Survivors
Researchers found that a combination of early menopause due to breast cancer treatment and common drugs used to treat breast cancer, could be weakening the bones of breast cancer survivors once they hit middle age, leading to hip fractures. [Press release from ScienceDaily discussing online prepublication in Clinical Cancer Research]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells
Despite evidence supporting an oncogenic role in breast cancer, the Notch pathway’s contribution to metastasis remains unknown. Scientists report that the Notch ligand Jagged1 is a clinically and functionally important mediator of bone metastasis by activating the Notch pathway in bone cells. [Cancer Cell ]

A Novel Role for BRCA1 In Regulating Breast Cancer Cell Spreading and Motility 
Scientists conclude that full-length BRCA1 is important for complete tumor suppressor activity via interaction of its BRCA1 C-terminal domains with ezrin-radixin-moesin at the plasma membrane, controlling spreading and motility of cancer cells via ubiquitin ligase activity. [J Cell Biol]

Identification of a Tumor Suppressor Relay Between the FOXP3 and the Hippo Pathways in Breast and Prostate Cancers
Scientists report that spontaneous mutation of the transcription factor FOXP3 reduces expression of the LATS2 gene in mammary epithelial cells. [Cancer Res]

A Mammaglobin-A Targeting Agent for Noninvasive Detection of Breast Cancer Metastasis in Lymph Nodes
Scientists describe an imaging platform for noninvasive assessment of axillary lymph node status, eliminating the need for surgical examination of patients to rule out nodal involvement. [Cancer Res]

Translationally Controlled Tumor Protein Induces Human Breast Epithelial Cell Transformation Through the Activation of Src
Investigators examined translationally controlled tumor protein-induced tumor progression signaling networks in human breast epithelial cells, using adenoviral infection. [Oncogene]

PI3K Inhibition Results in Enhanced HER Signaling and Acquired ERK Dependency in HER2-Overexpressing Breast Cancer
Findings indicate that PI3K inhibition in HER2-overexpressing breast cancer activates a new compensatory pathway that results in ERK dependency. [Oncogene]

Prolactin-Induced Mouse Mammary Carcinomas Model Estrogen Resistant Luminal Breast Cancer
Since epidemiologic studies closely link prolactin and the development of estrogen receptor alpha (ERalpha+) tumors in women, scientists examined characteristics of the aggressive ERalpha+ and ERalpha- carcinomas which develop in response to mammary prolactin in a murine transgenic model (neu-related lipocalin – prolactin (NRL-PRL)). [Breast Cancer Res]

The Effect of a DNA Repair Gene on Cellular Invasiveness: XRCC3 Over-Expression in Breast Cancer Cells
Scientists assessed the effect of the DNA repair proteins known as X-ray complementing protein 3 (XRCC3) and RAD51, to the invasive behavior of the MCF-7 luminal epithelial-like and BT20 basal-like triple negative human breast cancer cell lines. [PLoS One]


JS-K, a Nitric Oxide-Releasing Prodrug, Induces Breast Cancer Cell Death while Sparing Normal Mammary Epithelial Cells
Scientists investigated the effects of JS-K, a nitric oxide (NO) prodrug designed to release high levels of NO when suitably activated, on human breast cancer cell lines, on non-transformed human MCF-10A mammary cells, and on normal human mammary epithelial cells. [Int J Oncol]


CLINICAL RESEARCH

Common Variants in ZNF365 Are Associated with Both Mammographic Density and Breast Cancer Risk
Researchers conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10-10). [Nat Genet]

Cancer Therapy Associated Bone Loss: Implications for Hip Fractures in Mid-Life Women with Breast Cancer
Scientists present a case series of breast cancer survivors and a systematic review of bone health care in breast cancer. [Clin Cancer Res]

Preoperative Sentinel Node Identification with Ultrasound Using Microbubbles in Patients With Breast Cancer
The aim of this study was to identify and localize sentinel lymph nodes preoperatively by contrast-enhanced sonography after intradermal injection of microbubbles in patients with breast cancer. [Am J Roentgenol]

Expression of the Embryonic Stem Cell Marker SOX2 In Early-Stage Breast Carcinoma
In this study, investigators assessed SOX2 expression in 95 primary tumors of postmenopausal breast cancer patients. [BMC Cancer]




INDUSTRY NEWS

Breast Cancer Physician Named “Outstanding Hispanic”
Orlando E. Silva, M.D., J.D. was chosen to receive the “Outstanding Hispanic Award” at The Americano’s First Annual Hispanic Forum, held in Washington, D.C.. [University of Miami Miller School of Medicine Press Release]

$1 Million Donation Enables Enhanced Breast Cancer Detection
TELUS’ Go Pink campaign has raised over $1 million for the BC Women’s Hospital Foundation. The campaign raised a total of more than $2 million for women’s breast health across Canada. [TELUS Media Press Release]

Sanofi-aventis Reports Top-Line Results from Phase III Study with BSI-201 in Metastatic Triple-Negative Breast Cancer
Sanofi-aventis and its subsidiary, BiPar Sciences, announced that a randomized Phase III trial evaluating BSI-201 (iniparib*) in patients with metastatic triple-negative breast cancer did not meet the pre-specified criteria for significance for co-primary endpoints of overall survival and progression-free survival. [Sanofi-aventis Press Release]



POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)



EVENTS

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JOB OPPORTUNITIES

Lab Technologist – Cell Separation (STEMCELL Technologies)

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Assistant Professor (University of Pittsburgh School of Medicine, Center for Cellular and Molecular Engineering)

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Post-doctoral Fellowship (University of Pittsburgh)

Post-doctoral Position in Biochemistry/Molecular Cancer Research (Université d’Auvergne)

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