Volume 3.01 | Jan 13

Mammary Cell News 3.01 January 13, 2011.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Increased Efficacy of Breast Cancer Chemotherapy in Thrombocytopenic Mice  ShareThis
Scientists hypothesized that inducing thrombocytopenia in tumors would increase vascular leakiness and facilitate the effective delivery of chemotherapeutic agents to tumors. [Cancer Res]

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SCIENCE NEWS

Avastin Raises Heart Failure Risk in Breast Cancer
Women with advanced breast cancer who were treated with Roche’s Avastin were more likely to develop heart failure than other women. [Press release from Reuters discussing online prepublication in the Journal of Clinical Oncology]

High Dietary Fat, Cholesterol Linked to Increased Risk of Breast Cancer 
Elevated fat and cholesterol levels found in a typical American-style diet play an important role in the growth and spread of breast cancer, say researchers. [Press release from Thomas Jefferson University Hospitals discussing online prepublication in The American Journal of Pathology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

The Role of Calcium in the Activation of Estrogen Receptor-Alpha
Researchers investigated whether intracellular calcium mediates the crosstalk between signaling pathways that activate estrogen receptor-alpha and the ligand binding domain of the receptor [Cancer Res]

Role of Cholesterol in the Development and Progression of Breast Cancer
The present study examined the role of cholesterol in the regulation of tumor progression in a mouse model of mammary tumor formation. [Am J Pathol]
 

Syndecan-1 in Breast Cancer Stroma Fibroblasts Regulates Extracellular Matrix Fiber Organization and Carcinoma Cell Motility
To examine a possible link between stromal cell surface proteoglycan syndecan-1 (Sdc1) and the fiber architecture, scientists generated bioactive cell-free three-dimensional extracellular matrix (ECM)s from cultures of Sdc1-positive and Sdc1-negative murine and human mammary fibroblasts (termed ECM-Sdc1 and ECM-mock, respectively). [Am J Pathol]

Alpha-TEA Cooperates with Chemotherapeutic Agents to Induce Apoptosis of p53 Mutant, Triple Negative Human Breast Cancer Cells via Activating p73
Investigators report on the reconstitution of the p53 tumor suppressor pathway in a p53-independent manner via p73 with combination treatments of alpha-TEA, a small bioactive lipid, plus doxorubicin or cisplatin. [Breast Cancer Res]


Silencing of Tubulin Binding Cofactor C Modifies Microtubule Dynamics and Cell Cycle Distribution and Enhances Sensitivity to Gemcitabine in Breast Cancer Cells
Scientists investigated the influence of Tubulin Binding cofactor C (TBCC) silencing on tubulin pools, microtubule dynamics and cell cycle distribution of breast cancer cells by developing a variant MCF7 cells with reduced content of TBCC. [Mol Cancer Ther]


Prognostic Significance of Methylated RASSF1A and PITX2 Genes in Blood- and Bone Marrow Plasma of Breast Cancer Patients
Researchers investigated the prognostic value of two promising genes, PITX2 and RASSF1A, in peripheral blood-plasma and bone marrow plasma of breast cancer patients. [Breast Cancer Res Treat]

Cytoplasmic Compartmentalization of SOX9 Abrogates the Growth Arrest Response of Breast Cancer Cells That Can Be Rescued by Trichostatin A Treatment
Investigators show here that SOX9 expression is nuclear in ductal epithelial cells throughout mammary gland development and differentiation but is localized in the cytoplasm of some breast cancer cell lines. [Cancer Biol Ther]

TGF-Beta1 and BRCA2 Expression Are Associated with Clinical Factors in Breast Cancer
The objective of this study was to investigate the possible association between the expression of transforming growth factor beta-1 (TGF-beta1) and breast cancer type 2 susceptibility protein (BRCA2) with clinical factors in breast cancer. [Cell Biochem Biophys]

CLINICAL RESEARCH

Congestive Heart Failure Risk in Patients with Breast Cancer Treated With Bevacizumab
Scientists performed an up-to-date, comprehensive meta-analysis to determine the risk of serious congestive heart failure in patients with breast cancer receiving bevacizumab. [J Clin Oncol]


Magnetic Resonance Imaging Response Monitoring of Breast Cancer During Neoadjuvant Chemotherapy: Relevance of Breast Cancer Subtype
The study’s purpose was to evaluate the relevance of breast cancer subtypes for magnetic resonance imaging markers for monitoring of therapy response during neoadjuvant chemotherapy. [J Clin Oncol]




INDUSTRY NEWS

BIND Biosciences Initiates Phase I Clinical Study of BIND-014
BIND Biosciences announced that it has initiated a Phase I clinical trial to assess the safety, tolerability and pharmacokinetic profile of BIND-014 in cancer patients. [BIND Biosciences Press Release]

Avesthagen Completes the First Whole Genome Sequence of a Parsi Breast Cancer Patient
Avesthagen Limited announces the completion of the first Parsi breast cancer whole genome sequence of a 74-year-old Parsi woman with a heritable form of breast cancer. [Avesthagen Limited Press Release]

Veridex, LLC Announces Collaboration to Develop Next-Generation Circulating Tumor Cell Technology with Massachusetts General Hospital
Veridex, LLC announced a collaboration with Massachusetts General Hospital to develop and commercialize a next-generation circulating tumor cell technology for capturing, counting and characterizing tumor cells found in patients’ blood. [Johnson & Johnson Press Release]

Adventist Hospitals Receive Komen Grant to Expand Access to Breast Cancer Screenings for Local Women
Local women will have improved access to breast care services thanks to a nearly $1 million grant Adventist HealthCare has received from Susan G. Komen for the Cure. [Adventist Health Care Press Release]




POLICY NEWS

NICE to Recruit Specialists to Advise on Assessment of Breast Cancer Test
Recruitment is underway for five specialists to join the National Institute for Health and Clinical Excellence (NICE)’s Diagnostics Advisory Committee as it considers the clinical and cost effectiveness of a DNA based biochip assay which examines breast cancer tumour markers. [National Institute for Health and Clinical Excellence, United Kingdom]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)




EVENTS

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Higher Scientific Officer : London United Kingdom (The Institute of Cancer Research)

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