Volume 2.47 | Dec 16

Mammary Cell News 2.47 December 16, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Protein Disables p53, Drives Breast Cells Toward Cancer Transition  ShareThis
Researchers found that TRIM24 (tripartite motif-containing 24) pushes estrogen-responsive genes toward active expression. This expression, in turn, sets the stage for malignant transformation of breast cells. [Press release from The University of Texas MD Anderson Cancer Center discussing online prepublication in Nature]

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SCIENCE NEWS

Single Gene Essential for Estrogen Response in Breast Cancer
Scientists have discovered that a single gene controls the estrogen-fuelled growth of breast cancer cells, according to research. [Press release from Cancer Research UK discussing online prepublication in Nature Genetics]

Nanoscale Gene “Ignition Switch” May Help Spot and Treat Cancer
In a proof of principal study in mice, scientists have shown that a set of genetic instructions encased in a nanoparticle can be used as an “ignition switch” to rev up gene activity that aids cancer detection and treatment. [Press release from Johns Hopkins Medicine discussing online prepublication in Nature Medicine]

The Stemness of Cancer Cells
To find out whether p53 inactivation does permit the emergence of tumor cells resembling stem cells, researchers combed through hundreds of archival gene expression profiles of breast and lung tumors, searching for stem cell-like signatures and correlating them to their p53 status. [Press release from the Salk Institute for Biological Studies discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

Breast Inflammation is Key to Cancer Growth, Kimmel Cancer Center Researchers Say
Scientists say they can now definitively show that an inflammatory process within the breast itself promotes growth of breast cancer stem cells responsible for tumor development. [Press release from EurekAlert! discussing online prepublication in Cancer Research]

Defective Cell Surface “Glue” Is Key to Tumor Invasion
The study shows that a non-adhesive form of N-cadherin, termed proNcad is present in a much higher proportion on the surfaces of the most invasive melanoma, brain tumor cells, breast cancer and prostate tumor cells, compared to less invasive tumor cells. [Press release from McGill University Health Center discussing online prepublication in Neoplasia]

Poor Breast Cancer Prognosis Associated With Presence of Circulating Tumor, Cancer Stem Cells
Metastatic breast cancer patients whose blood contains circulating tumor cells before or after treatment with high-dose chemotherapy and blood stem cell transplant have shorter survival periods, according to a new study. [Press release from The University of Texas MD Anderson Cancer Center discussing data presented at the 33rd Annual Cancer Therapy & Research Center-American Association for Cancer Research San Antonio Breast Cancer Symposium]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

TRIM24 Links a Non-Canonical Histone Signature to Breast Cancer
Here, researchers report that chromatin regulator tripartite motif-containing 24 (TRIM24) functions in humans as a reader of dual histone marks by means of tandem plant homeodomain and bromodomain regions. [Nature]

FOXA1 is a Key Determinant of Estrogen Receptor Function and Endocrine Response
Here, researchers show that FOXA1 is a key determinant that can influence differential interactions between estrogen receptor-alpha and chromatin. [Nat Genet]

Tumor-Specific Imaging Through Progression Elevated Gene-3 Promoter-Driven Gene Expression
Here, researchers show that the progression elevated gene-3 (PEG-3) promoter, derived from a rodent gene mediating tumor progression and metastatic phenotypes, can be used to drive imaging reporters selectively to enable detection of micrometastatic disease in mouse models of human melanoma and breast cancer using bioluminescence and radionuclide-based molecular imaging techniques. [Nat Med]

Inactivation of p53 in Breast Cancers Correlates with Stem Cell Transcriptional Signatures
Using archival microarray datasets, researchers tested the hypothesis that a p53 mutation could allow cells within a tumor to acquire a stem cell-like state by looking for coordinate expression of stem cell identity genes. [Proc Natl Acad Sci USA]

Fes Tyrosine Kinase Expression in the Tumor Niche Correlates with Enhanced Tumor Growth, Angiogenesis, Circulating Tumor Cells, Metastasis and Infiltrating Macrophages
In an orthotopic mouse model of breast cancer, researchers found that loss of Fes in the host correlated with reductions in engrafted tumor growth rates, metastasis and circulating tumor cells. [Cancer Res]

ETV6-NTRK3 Mediated Breast Epithelial Cell Transformation Is Blocked by Targeting the IGF1R Signaling Pathway
The IGF1 receptor (IGF1R) is an important therapeutic target under study in many cancers. Here, researchers describe a breast cancer model based on expression of the ETV6-NTRK3 chimeric tyrosine kinase that suggests novel therapeutic applications of IGF1R inhibitors in secretory breast cancers. [Cancer Res]

The Canonical NF-KappaB Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion
As researchers show that NF-kappaB contributes to expansion of breast tumor stem cells and heterotypic signals that enhance tumor-associated macrophages and vasculogenesis, these processes may contribute to NF-kappaB-dependent mammary tumorigenesis. [Cancer Res]

KLF8 Promotes Human Breast Cancer Cell Invasion and Metastasis by Transcriptional Activation of MMP9
To identify the potential Krüppel-like factor 8 (KLF8) regulation of matrix metalloproteinases in breast cancer, researchers established two inducible cell lines that allow either KLF8 overexpression in MCF-10A or knockdown in MDA-MB-231 cells. [Oncogene]

Toward an Automatic Method for Extracting Cancer- and Other Disease-Related Point Mutations from the Biomedical Literature
Researchers introduce a high-throughput computational method for the identification of relevant disease mutations in Pub-Med abstracts applied to prostate (PCa) and breast cancer (BCa) mutations. [Bioinformatics]

CLINICAL RESEARCH

Phase III Randomized Study Comparing Docetaxel Plus Trastuzumab with Vinorelbine Plus Trastuzumab As First-Line Therapy of Metastatic or Locally Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: The HERNATA Study
The purpose of this study was to evaluate docetaxel or vinorelbine, both with trastuzumab, as first-line therapy of human epidermal growth factor receptor 2-positive advanced breast cancer. [J Clin Oncol]

Decrease in Depression Symptoms Is Associated With Longer Survival in Patients with Metastatic Breast Cancer: A Secondary Analysis
Decreasing depression symptoms over the first year were associated with longer subsequent survival for women with metastatic breast cancer in this sample. [J Clin Oncol]



INDUSTRY NEWS

Study of Novartis Drug Zometa for Potential New Use in Early Breast Cancer Did Not Meet Primary Endpoint in Overall Study Population
Results from the second interim analysis of the Phase III AZURE (Adjuvant Zoledronic acid to redUce REcurrence) trial show that Zometa® (zoledronic acid) did not demonstrate a disease-free survival advantage when added to standard adjuvant (post-surgery) chemotherapy and/or hormonal therapy in pre- and postmenopausal women with early breast cancer. [Novartis Press Release]

Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients
A new study shows that the addition of everolimus (Afinitor® tablets) to the hormonal therapy tamoxifen in patients with hormone-receptor positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast cancer who have been previously treated with an aromatase inhibitor (AI) delays disease progression compared to tamoxifen alone. [Novartis Press Release]

Universities Develop 3D X-Rays to Target Breast Cancer
Durham University spin-out, Kromek, has secured a $4 million contract from the U.S. National Institute for Health to develop 3D breast-scanning technology. [The Engineer]



POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)



EVENTS (Listed by Date)

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment
February 23-25, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
February 24-27, 2011
San Francisco, United States

Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

28th Annual Miami Breast Cancer Conference
March 9-12, 2011
Miami, United States

MENA Oncology Conference
March 11-12, 2011
Cairo, Egypt

PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

Third Annual European Network of Breast Development and Cancer Labs (ENBDC) Workshop: Methods in Mammary Gland Biology and Breast Cancer
April 29 – May 1, 2011
Weggis, Switzerland

World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

National Cancer Institute (NCI) Cancer Research Imaging Camp
June 19-24, 2011
St. Louis, United States

4th Annual Advances in Biodetection & Biosensors Conference and Exhibition
June 30-July 1, 2011
Hamburg, Germany

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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