Volume 2.45 | Dec 2

Mammary Cell News 2.45 December 2, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Sporadic Breast Cancers Start with Ineffective DNA Repair Systems, Pitt Researchers Find  ShareThis
Breast cancers that arise sporadically, rather than through inheritance of certain genes, likely start with defects of DNA repair mechanisms that allow environmentally triggered mutations to accumulate, according to researchers. [Press release from the University of Pittsburgh Schools of the Health Sciences discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

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SCIENCE NEWS

News Note: Scientists Identify Molecular Link Between BRCA1 Protein Levels and Obesity
NCI researchers have defined a possible molecular link between breast cancer risk and obesity. New study results show that a protein called C-terminal binding protein (CtBP) acts to control a gene linked to breast cancer risk in rapidly growing cells by monitoring and responding to how the cells use and store energy (metabolic state). [Press release from the National Cancer Institute discussing online prepublication in Nature Structural and Molecular Biology]

Magnetic Field Directs Nanoparticles to Tumors
To improve the tumor-specific delivery of drug to tumors, a team of investigators from the University of California, San Diego has created a system of nanoparticles-within-a-nanoparticle that can be directed to and concentrated at the site of the tumor using a magnetic field. [Press release from the National Cancer Institute discussing online prepublication in Nano Letters]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release
Nanocapsules containing intentionally trapped magnetic nanoparticles and defined anticancer drugs have been prepared to provide a powerful magnetic vector under moderate gradient magnetic fields. In vitro as well as in vivo results indicate that these nanocapsules can be enriched near the mouse breast tumor and are effective in reducing tumor cell growth. [Nano Lett]

Nucleotide Excision Repair Deficiency Is Intrinsic in Sporadic Stage I Breast Cancer
Taken together, the data suggest that nucleotide excision repair (NER) deficiency may play an important role in the etiology of sporadic breast cancer, and that early-stage breast cancer may be intrinsically susceptible to genotoxic chemotherapeutic agents, such as cis-platinum, whose damage is remediated by NER. [Proc Natl Acad Sci USA]

Profilin1 Regulates PI(3,4)P2 and Lamellipodin Accumulation at the Leading Edge Thus Influencing Motility of MDA-MB-231 Cells
In this study, researchers show that profilin1 negatively regulates lamellipodin targeting to the leading edge in MDA-MB-231 breast cancer cells and normal cells; profilin1 depletion increases lamellipodin concentration at the lamellipodial tip (where it binds Ena/VASP), and this mediates the hypermotility. [Proc Natl Acad Sci USA]

Systematic Detection of Putative Tumor Suppressor Genes Through the Combined Use of Exome and Transcriptome Sequencing
To identify potential tumor suppressor genes, genome-wide data from exome and transcriptome sequencing were combined to search for genes with loss of heterozygosity and allele specific expression. The analysis was conducted on the breast cancer cell line, HCC1954, and a lymphoblast cell line from the same individual, HCC1954BL. [Genome Biol]

Evidence for SMAD3 as a Modifier of Breast Cancer Risk in BRCA2 Mutation Carriers
Current attempts to identify genetic modifiers of BRCA1 and BRCA2 associated risk have focused on a candidate gene approach, based on knowledge of gene functions, or the development of large genome wide association studies. In this study, researchers evaluated 24 single nucleotide polymorphisms tagged to 14 candidate genes derived through a novel approach that analysed gene expression differences to prioritize candidate modifier genes for association studies. [Breast Cancer Res]

Mena Deficiency Delays Tumor Progression and Decreases Metastasis in Polyoma Middle-T Transgenic Mouse Mammary Tumors
The actin binding protein Mammalian enabled (Mena), has been implicated in the metastatic progression of solid tumors in humans. Here, researchers report the effects of Mena deficiency on tumor progression, metastasis and on normal mammary gland development. [Breast Cancer Res]

Epigenetic Control of the Basal-Like Gene Expression Profile via Interleukin-6 in Breast Cancer Cells
Researchers conclude that IL-6, whose methylation-dependent autocrine loop is triggered by the inactivation of p53, induces an epigenetic reprogramming that drives breast carcinoma cells towards a basal-like/stem cell-like gene expression profile. [Mol Cancer]

CLINICAL RESEARCH

Effect of Obesity on Prognosis After Early-Stage Breast Cancer
This study was performed to characterize the impact of obesity on the risk of breast cancer recurrence and death as a result of breast cancer or other causes in relation to adjuvant treatment. [J Clin Oncol]



INDUSTRY NEWS

Seattle Genetics May Be First on Market With Cancer Combo That Beats Roche
Seattle Genetics Inc. and Takeda Pharmaceutical Co. may beat Roche Holding AG in developing a new type of combination cancer therapy that’s less toxic than standard treatments. [Bloomberg]

MDxHealth Licenses Methylation Technology to Takara Bio Inc. for Scientific Research Market
MDxHealth SA, a leading molecular diagnostics company in the field of personalized cancer treatment, announced that it has granted a non-exclusive worldwide license for its patented methylation specific PCR (MSP) technology to Takara Bio Inc. [MDxHealth SA Press Release]



POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)



EVENTS (Listed by Date)

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

American Association for Cancer Research (AACR) 33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment
February 23-25, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
February 24-27, 2011
San Francisco, United States

NEW Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

28th Annual Miami Breast Cancer Conference
March 9-12, 2011
Miami, United States

MENA Oncology Conference
March 11-12, 2011
Cairo, Egypt

NEW PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

NEW World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

National Cancer Institute (NCI) Cancer Research Imaging Camp
June 19-24, 2011
St. Louis, United States

4th Annual Advances in Biodetection & Biosensors Conference and Exhibition
June 30-July 1, 2011
Hamburg, Germany

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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