Volume 2.44 | Nov 25

Mammary Cell News 2.44 November 25, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY


Discovery Halts Breast Cancer Stem Cells  ShareThis
Breast cancer stem cells (CSCs) are stimulated by estrogen via a pathway that mirrors normal stem cell development. Disrupting the pathway, researchers were able to halt the expansion of breast CSCs, a finding that suggests a new drug therapy target. [Press release from Tufts University School of Medicine discussing online prepublication in Proceedings of the National Academy of Sciences USA]

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SCIENCE NEWS

UGA Researchers Identify Key Enzyme that Regulates the Early Growth of Breast Cancer Cells
New research has found that blocking the action of an enzyme called GnT-V significantly delays the onset and spread of tumors in mice with cancer very similar to many cases of human breast cancer. [Press release from the University of Georgia discussing online prepublication in Proceedings of the National Academy of Sciences USA]

New Function of Gene in Promoting Cancer Found by VCU Researchers
Researchers have discovered that a gene well known for its involvement in tumor cell development, growth and metastasis also protects cancer cells from being destroyed by chemotherapy. [Press release from Virginia Commonwealth University discussing online prepublication in Proceedings of the National Academy of Sciences USA]

The Most Aggressive Forms of Breast Cancer Elude Cellular Control Mechanisms in Order to Expand
Scientists have described the molecular mechanism that induces HER2+ tumors to ignore the signals that protect cells from excessive growth. [Press release from Institute for Research in Biomedicine Barcelona discussing online prepublication in Cancer Research]

Too Much of a Good Thing: Important Mechanism in Hormone-Sensitive Breast Cancer Uncovered
In two out of three breast tumors, extraordinarily high levels of the estrogen receptor ERalpha are found. Scientists have now uncovered a mechanism which causes this overproduction. [Press release from PhysOrg discussing online prepublication in Cancer Research]

MammoCultBreastCancer_645x110_v01



CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway
PI3K and PTEN lipid phosphatase control the level of cellular phosphatidylinositol (3,4,5)-trisphosphate, an activator of AKT kinases that promotes cell growth and survival. Mutations activating AKT are commonly observed in human cancers. Researchers report here that ENTPD5, an endoplasmic reticulum enzyme, is upregulated in cell lines and primary human tumor samples with active AKT. [Cell]

STAT3-Induced S1PR1 Expression is Crucial for Persistent STAT3 Activation in Tumors
Researchers show that expression of sphingosine-1-phosphate receptor-1, a G protein-coupled receptor for the lysophospholipid sphingosine-1-phosphate, is elevated in STAT3-positive tumors. [Nat Med]

Specific Posttranslational Modification Regulates Early Events in Mammary Carcinoma Formation
To determine the molecular basis of how early events in breast carcinoma formation are regulated by GnT-V, researchers studied both the early stages of mammary tumor formation by using 3D cell culture and a her-2 transgenic mouse mammary tumor model. [Proc Natl Acad Sci USA]

Estrogen Expands Breast Cancer Stem-Like Cells through Paracrine FGF/Tbx3 Signaling
Here, researchers report that, in analogy to embryonic mammary epithelial biology, estrogen signaling expands the pool of functional breast cancer stem cells through a paracrine FGF/FGFR/Tbx3 signaling pathway. [Proc Natl Acad Sci USA]

Astrocyte Elevated Gene-1 (AEG-1) Functions as an Oncogene and Regulates Angiogenesis
Researchers provide definitive evidence that astrocyte-elevated gene-1 (AEG-1) is indeed a transforming oncogene and show that stable expression of AEG-1 in normal immortal cloned rat embryo fibroblast cells induces morphological transformation and enhances invasion and anchorage-independent growth in soft agar, two fundamental biological events associated with cellular transformation. [Proc Natl Acad Sci USA]

HER2 Silences Tumor Suppression in Breast Cancer Cells by Switching Expression of C/EBPBeta Isoforms
In this study, researchers show that HER2-overexpressing breast cancer cells avert TGFbeta- and oncogene-induced senescence-mediated tumor suppression by switching expression of two functionally distinct isoforms of the transcription factor C/EBPbeta, which has been implicated previously in breast cancer development. [Cancer Res]

Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor Alpha in Breast Cancer Cells
Estrogen receptor alpha (ERalpha) upregulation causes abnormal cell proliferation in about two thirds of breast cancers, yet understanding of the underlying mechanisms remains incomplete. Here, researchers show that high expression of the microRNA miR-375 in ERalpha-positive breast cell lines is a key driver of their proliferation. [Cancer Res]

Effects of Human Mesenchymal Stem Cells on ER-Positive Human Breast Carcinoma Cells Mediated through ER-SDF-1/CXCR4 Crosstalk
Adult human mesenchymal stem cells (hMSCs) have been shown to home to sites of carcinoma and affect biological processes, including tumor growth and metastasis. Previous findings have been conflicting and a clear understanding of the effects of hMSCs on cancer remains to be established. Therefore, researchers set out to investigate the impact of hMSCs on the estrogen receptor positive, hormone-dependent breast carcinoma cell line MCF-7. [Mol Cancer]

CLINICAL RESEARCH

Using Mammographic Density to Predict Breast Cancer Risk: Dense Area or Percent Dense Area
Researchers measured mammographic density, including non-dense area (here a surrogate for weight), in the medio-lateral oblique (MLO) mammogram using a computer-assisted thresholding technique for 634 cases and 1880 age-matched controls from the Cambridge and Norwich Breast Screening Programs. [Breast Cancer Res]

INDUSTRY NEWS

U.S. FDA Approves Eisai’s Halaven (TM) (Eribulin Mesylate) Injection for Treatment of Metastatic Breast Cancer
Eisai Co., Ltd. announced that the United States Food and Drug Administration (FDA) approved the company’s novel anticancer agent Halaven™ (generic name: eribulin mesylate) injection on November 15 (United States local time) for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. [Eisai Co., Ltd. Press Release]



POLICY NEWS

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)



EVENTS (Listed by Date)

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

American Association for Cancer Research (AACR) 33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment
February 23-25, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
February 24-27, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

28th Annual Miami Breast Cancer Conference
March 9-12, 2011
Miami, United States

MENA Oncology Conference
March 11-12, 2011
Cairo, Egypt

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

National Cancer Institute (NCI) Cancer Research Imaging Camp
June 19-24, 2011
St. Louis, United States

4th Annual Advances in Biodetection & Biosensors Conference and Exhibition
June 30-July 1, 2011
Hamburg, Germany

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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