Volume 2.42 | Nov 4

Mammary Cell News 2.42 November 4, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Repression of Mammary Stem/Progenitor Cells by P53 is Mediated by Notch and Separable from Apoptotic Activity  ShareThis
The results demonstrate that basal levels of p53 restrict mammary stem/progenitor cells through Notch and that the Notch pathway is a therapeutic target to prevent expansion of this vulnerable pool of cells. [Stem Cells]

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SCIENCE NEWS

Nanoshells Provide Golden ‘Touch’ in Killing Breast Tumors
Using tiny gold “nanoshells” to deliver just a little heat to breast tumor cells already treated with radiation boosts the killing potential of the treatment – not just shrinking the tumor but killing the cancer stem cells, said researchers. [Press release from the Baylor College of Medicine discussing online prepublication in Science Translational Medicine]

Nanodrug Enables Image-Guided Breast Cancer Therapy
By combining an iron oxide nanoparticle, a tumor-targeting peptide, and a therapeutic nucleic acid into one construct, a team of investigators has created an agent that holds potential as targeted therapy for breast cancer. [Press release from the National Cancer Institute discussing online prepublication in Cancer Research]

Fox Chase Researchers Identify Risk Factors for the Spread of Breast Cancer to Lymph Nodes
By carefully examining recurrence patterns of thousands of women with breast cancer from records spanning more than 30 years, researchers have now shown that the appearance of lymphovascular invasion in breast tissue predicts the future recurrence of cancer to nearby lymph nodes. [Press release from the Fox Chase Cancer Center discussing data presented at the Annual Meeting of the American Society for Radiation Oncology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Magnetically Vectored Nanocapsules for Tumor Penetration and Remotely Switchable On-Demand Drug Release
Nanocapsules containing intentionally trapped magnetic nanoparticles and defined anticancer drugs have been prepared to provide a powerful magnetic vector under moderate gradient magnetic fields. [Nano Lett]

Autocrine TGF-Beta and Stromal Cell-Derived Factor-1 (SDF-1) Signaling Drives the Evolution of Tumor-Promoting Mammary Stromal Myofibroblasts
Using a coimplantation breast tumor xenograft model, researchers show that resident human mammary fibroblasts progressively convert into carcinoma-associated fibroblasts myofibroblasts during the course of tumor progression. [Proc Natl Acad Sci USA]

The Mitotic Kinase Aurora-A Induces Mammary Cell Migration and Breast Cancer Metastasis by Activating the Cofilin-F-actin Pathway
Here, researchers report that the mitotic kinase Aurora-A (Aur-A) promotes breast cancer metastasis. Aur-A overexpression enhanced mammary cell migration by dephosphorylation and activation of cofilin, which facilitates actin reorganization and polymerization. [Cancer Res]

Image-Guided Breast Tumor Therapy Using a Small Interfering RNA Nanodrug
In this study, researchers describe the synthesis and testing of a tumor-targeted nanodrug (MN-EPPT-siBIRC5) that is designed to specifically shuttle siRNA to human breast tumors. [Cancer Res]

Endoglin Expression in Breast Tumor Cells Suppresses Invasion and Metastasis and Correlates with Improved Clinical Outcome
Here, researchers demonstrate that endoglin is expressed in a subset of invasive breast cancers and cell lines and is subject to epigenetic silencing by gene methylation. [Oncogene]

P-Rex1 Participates in Neuregulin-ErbB Signal Transduction and its Expression Correlates with Patient Outcome in Breast Cancer
Here, researchers report the identification of the guanine nucleotide exchange factor, phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex1), as a novel mediator in signaling by ErbB/HER receptors. [Oncogene]

CdGAP is Required for Transforming Growth Factor Beta- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion
In this study, researchers found that Cdc42 GTPase-activating protein (CdGAP) and mRNA levels are highly increased in mammary tumor explants expressing an activated Neu/ErbB-2 receptor. [Oncogene]

Thermal Enhancement with Optically Activated Gold Nanoshells Sensitizes Breast Cancer Stem Cells to Radiation Therapy
Findings suggest that local hyperthermia delivered by gold nanoshells plus radiation can eliminate radioresistant breast cancer stem cells. [Sci Transl Med]

CLINICAL RESEARCH

Independent Association of Lobular Involution and Mammographic Breast Density With Breast Cancer Risk
To evaluate whether lobular involution and mammographic breast density are independently associated with breast cancer risk in women with benign breast disease, researchers performed a nested cohort study among women (n = 2666) with benign breast disease diagnosed at Mayo Clinic between January 1, 1985, and December 31, 1991 and a mammogram available within 6 months of the diagnosis. [J Natl Cancer Inst]

ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2
In this study, researchers show that ANCCA is overexpressed in >70% of breast tumors and that its high protein level correlates well with tumor histologic grades (P < 0.0001), highlighting ANCCA as a prognostic factor for poor overall survival and disease recurrence. [Cancer Res]



INDUSTRY NEWS

Quantum Immunologics Announces Significant Government Research Grant Approval
Quantum Immunologics, Inc., a Tampa, FL-based company currently engaged in an FDA-authorized clinical study of its autologous dendritic cell immunotherapy for Stage IV breast cancer patients, is pleased to announce that it has been awarded for each of three grant applications relating to the US Government’s Qualifying Therapeutics Discovery Project (QTDP) grant program. [Quantum Immunologics, Inc. Press Release]



POLICY NEWS

U.S. Says Genes Should Not Be Eligible for Patents
Reversing a longstanding policy, the federal government said on Friday that human and other genes should not be eligible for patents because they are part of nature. The new position could have a huge impact on medicine and on the biotechnology industry. [Department of Justice, United States]

NIH Introduces Images, a Database of Images in Biomedical Literature
More than 2.5 million images and figures from medical and life sciences journals are now available through Images, a new resource for finding images in biomedical literature. [National Institutes of Health, United States]

NIH Recovery Act Grants to Foster Scientific Workforce Diversity
The National Institutes of Health has awarded six grants totaling approximately $12 million over three years through a new initiative aimed at fostering a diverse scientific workforce. [National Institutes of Health, United States]

Guidelines for Use of Stored Specimens and Access to Ancillary Data and Proposed Cost Schedule: Stored Biologic Specimens and Ancillary Data From the Collaborative Perinatal Project (CPP) (FR Doc. 2010-27183) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27325) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27185) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27192) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27039) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27040) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27049) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26881) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-26935) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-27410) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-27187) [National Institutes of Health, United States]



EVENTS (Listed by Date)

National Cancer Research Institute (NCRI) Conference 2010
November 7-10, 2010
Liverpool, United Kingdom

9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
November 7-10, 2010
Philadelphia, United States

Third Annual Research Experience of Stem Cells in European Society (RESCUES) Conference
November 8-9, 2010
Oxford, United Kingdom

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

American Association for Cancer Research (AACR) 33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States

Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment
February 23-25, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
February 24-27, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

28th Annual Miami Breast Cancer Conference
March 9-12, 2011
Miami, United States

MENA Oncology Conference
March 11-12, 2011
Cairo, Egypt

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

NEW National Cancer Institute (NCI) Cancer Research Imaging Camp
June 19-24, 2011
St. Louis, United States

4th Annual Advances in Biodetection & Biosensors Conference and Exhibition
June 30-July 1, 2011
Hamburg, Germany

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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