Volume 2.40 | Oct 21

Mammary Cell News 2.40 October 21, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Research Team Identifies New Mechanism with Suspected Role in Cancer  ShareThis
Researchers have identified a process in which prolactin receptors can be drawn together and begin working in dimers. Overexpression of prolactin receptors in patients has been linked to cancer. [Press release from Brown University discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

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SCIENCE NEWS

New Clues to How Cancer-Related Proteins Plasmin, Thrombin Lose Inhibition
A new technique that searches blood for the tiniest remnants of broken down proteins has revealed new information about how cells crank up proteases. The results improve researchers’ understanding of the mechanics of breast cancer and point to where to look for possible indicators of early disease. [Press release from the Pacific Northwest National Laboratory discussing online prepublication in PLoS ONE]

Hormone Therapy Use by Postmenopausal Women Associated With Increased Incidence of More Advanced Breast Cancer
Follow-up of about 11 years of participants in the Women’s Health Initiative finds that among postmenopausal women, use of estrogen plus progestin is associated with an increased incidence of breast cancers that are more advanced, and with a higher risk of deaths attributable to breast cancer, according to a study. [Press release from the Los Angeles Biomedical Research Institute discussing online prepublication in the Journal of the American Medical Association]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Cdc42-Interacting Protein 4 Promotes Breast Cancer Cell Invasion and Formation of Invadopodia through Activation of N-WASp
Researchers found that expression of CIP4, but not TOCA-1 or FBP17, was increased in invasive breast cancer cell lines in comparison with weakly or noninvasive breast cancer cell lines. [Cancer Res]

High Levels of Hsp90 Cochaperone p23 Promote Tumor Progression and Poor Prognosis in Breast Cancer by Increasing Lymph Node Metastases and Drug Resistance
To gain a comprehensive view of the effects of p23 on estrogen receptor-dependent and -independent gene expression, researchers profiled mRNA expression from control versus MCF-7+p23 cells in the absence and presence of estrogen. [Cancer Res]

Automated Extraction of DNA and RNA From a Single Formalin-Fixed Paraffin-Embedded Tissue Section for Analysis of Both Single-Nucleotide Polymorphisms and mRNA Expression
Researchers investigated a fully automated, xylene-free nucleic acid extraction method for the simultaneous analysis of RNA and DNA biomarkers related to breast cancer. [Clin Chem]

Genomic Collaboration of Estrogen Receptor-Alpha and ERK2 in Regulating Gene and Proliferation Programs
In these studies, researchers document that estrogen-occupied estrogen receptor (ER)-alpha activates and interacts with ERK2, a downstream effector in the MAPK pathway, resulting in ERK2 and ER-alpha colocalization at chromatin binding sites across the genome of breast cancer cells. [Mol Cell Biol]

PTP1B Suppresses Prolactin Activation of Stat5 in Breast Cancer Cells
Collectively, the data implicate tyrosine phosphatase PTP1B as an important negative regulator of Stat5 phosphorylation in invasive breast cancer. [Am J Pathol]

ErbB2 Stabilizes Epidermal Growth Factor Receptor (EGFR) Expression via Erk and Sprouty2 in Extracellular Matrix Detached Cells
Researchers show that there is a significant decrease in the stability of EGFR in extracellular matrix-detached cells which is reversed by ErbB2 overexpression. [J Biol Chem]

Fetuin-A (ahsg) Is A Major Serum Adhesive Protein That Mediates Growth Signaling in Breast Tumor Cells
In the present analyses, researchers show that fetuin-A whose function in cellular attachment in tissue culture has been debated for many years, is indeed a major serum cell attachment factor particularly for tumor cells. [J Biol Chem]

A Multigene Predictor of Metastatic Outcome in Early Stage Hormone Receptor-Negative and Triple-Negative Breast Cancer
A multigene hormone receptor negative/triple-negative (HRneg/Tneg) signature linked to immune/inflammatory cytokine regulation was identified from pooled expression microarray data and shown to be superior to other reported gene signatures in predicting the metastatic outcome of early stage and conservatively managed HRneg and Tneg breast cancer. [Breast Cancer Res]

CLINICAL RESEARCH

Estrogen Plus Progestin and Breast Cancer Incidence and Mortality in Postmenopausal Women
The objective of this study was to determine the effects of therapy with estrogen plus progestin on cumulative breast cancer incidence and mortality after a total mean follow-up of 11.0 (SD, 2.7) years, through August 14, 2009. [JAMA]

Assessment of Clinical Validity of a Breast Cancer Risk Model Combining Genetic and Clinical Information
Combining validated common genetic risk factors with clinical risk factors resulted in modest improvement in classification of breast cancer risks in white non-Hispanic postmenopausal women. [J Natl Cancer Inst]

Urine Metabolite Analysis Offers Potential Early Diagnosis of Ovarian and Breast Cancers
Metabolomics is a new, rapidly expanding field dedicated to the global study of metabolites in biological systems. In this manuscript metabolomics is applied to find urinary biomarkers for breast and ovarian cancer. [Clin Cancer Res]

Blood Peptidome-Degradome Profile of Breast Cancer
The peptidome-degradome profiles of pooled blood plasma sampled from 15 breast cancer patients and age, race, and menopausal status matched control healthy persons were globally characterized using advanced comprehensive separations combined with tandem Fourier transform mass spectrometry and new data analysis approaches that facilitated top-down peptidomic analysis. [PLoS ONE]



INDUSTRY NEWS

NIH Awards Karmanos Cancer Institute Breast Cancer Researchers Nearly $3 Million for Ground-Breaking Immunotherapy Clinical Study
Scientists have received a nearly $3 million, five-year research project grant from the National Institutes of Health to study a potentially ground-breaking immunotherapy treatment for women with triple-negative breast cancer. [Barbara Ann Karmanos Cancer Institute Press Release]

Medifocus, Inc. Announces Institutional Review Board (IRB) Approval for its Phase III Pivotal Breast Cancer Treatment Study
Medifocus, Inc. is pleased to announce that the University of Oklahoma Health Sciences Center’s Institutional Review Board (IRB) has granted final approval to conduct Medifocus’ Pivotal Phase III Breast Cancer Treatment Study at the University of Oklahoma Breast Institute. [Medifocus, Inc. Press Release]



POLICY NEWS

European Medicines Agency Strengthens Rules on Conflicts of Interests of Its Scientific Experts
The European Medicines Agency has published new rules on how the Agency will be handling potential conflicts of interests of its scientific experts, following endorsement by its Management Board. [European Medicines Agency, European Union]

IQWiG: Law Must Prescribe Obligation to Publish All Clinical Trials
If the currently discussed draft on the “Law on the Reorganization of the Pharmaceutical Market” (AMNOG) is implemented, drug manufacturers will in future have to register their clinical trials at inception and publish results after completion. [Institute for Quality and Efficiency in Health Care (IQWiG), Germany]

Loss of UK Genetics Public Bodies Confirmed
The official announcement from the UK Government on the future of non-departmental public bodies has confirmed the rumored abolition of a total of 192 public bodies, with a further 118 to be merged. [Foundation for Genomics and Population Health, United Kingdom]

HHS to Let Secretary’s Genetics Committee Expire 
The Secretary’s Advisory Committee on Genetics, Health, and Society will disband next month, eight years after its founding. The committee had completed its original task, advising the Department of Health and Human Services (HHS) on a number of issues related to genomics. [Department of Health and Human Services, United States]

Screening Framework Guidance for Providers of Synthetic Double-Stranded DNA (FR Doc. 2010-25728) [Department of Health and Human Services, United States]

Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational Science Awards (CTSA) Initiative (FR Doc. 2010-25589) [Department of Health and Human Services, United States]

Agency Information Collection Request. 30-Day Public Comment Request (FR Doc. 2010-25587) [Department of Health and Human Services, United States]

Partnerships To Advance the National Occupational Research Agenda (NORA) (FR Doc. 2010-25973) [Centers for Disease Control and Prevention, States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-26036) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-25634) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25595) [National Institutes of Health, United States]



EVENTS (Listed by Date)

Frontiers in Tumour Progression
October 24-27, 2010
Madrid, Spain

2nd Annual Stem Cells Asia and Regenerative Medicine Congress 2010
October 26-28, 2010
Seoul, Korea

UAE Cancer Congress 2010
October 28-30, 2010
Dubai, United Arab Emirates

NEW 5th UK Cancer Stem Cell Symposium
November 2, 2010
London, United Kingdom

National Cancer Research Institute (NCRI) Conference 2010
November 7-10, 2010
Liverpool, United Kingdom

9th Annual American Association for Cancer Research (AACR) International Conference: Frontiers in Cancer Prevention Research
November 7-10, 2010
Philadelphia, United States

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

22nd European Organization for Research and Treatment of Cancer (EORTC)-National Cancer Institute (NCI)-American Association for Cancer Research (AACR) Symposium: Molecular Targets and Cancer Therapeutics
November 16-19, 2010
Berlin, Germany

Tumor Immunology: Basic and Clinical Advances
November 30-December 3, 2010
Miami, United Sates

NEW 5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

American Association for Cancer Research (AACR) 33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States

NEW Keystone Symposia: Epithelial Plasticity and Epithelial to Mesenchymal Transition
January 21-26, 2011
Vancouver, Canada

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

NEW Molecular Medicine Tri-Conference: Inaugural Circulating Tumor Cells for Cancer Detection, Diagnosis, Prognosis and Treatment
February 23-25, 2011
San Francisco, United States

NEW American Association for Cancer Research (AACR) Targeting PI3K/mTOR Signaling in Cancer
February 24-27, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

28th Annual Miami Breast Cancer Conference
March 9-12, 2011
Miami, United States

MENA Oncology Conference
March 11-12, 2011
Cairo, Egypt

American Association for Cancer Research (AACR) 102nd Annual Meeting 2011
April 2-6, 2011
Orlando, United States

International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

4th Annual Advances in Biodetection & Biosensors Conference and Exhibition
June 30-July 1, 2011
Hamburg, Germany

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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