Volume 2.35 | Sep 16

Mammary Cell News 2.35 September 16, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation  ShareThis
Researchers describe a small molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in fibroblasts, and the growth of human breast cancer and B lymphoma cells, without affecting normal cells. [Cancer Cell]

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SCIENCE NEWS

Calcium Deposits Could Improve Breast Cancer Diagnosis
Scientists have discovered for the first time that studying calcium deposits in the breast, often detected through screening, could help doctors diagnose breast cancer more effectively. [Press release from Cancer Research UK discussing online prepublication in the British Journal of Cancer]

Stress Accelerates Breast Cancer Progression in Mice
This study provides a model that not only demonstrates that stress can speed up cancer progression, but also details the pathway used to change the biology of immune cells that inadvertently promote the spread of cancer to distant organs, where it is much harder to treat. [Press release from EurekAlert! discussing online prepublication in Cancer Research]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells
In an inducible oncogenesis model, the miR-200 family is inhibited during cancer stem cell (CSC) formation but not transformation, and inhibition of miR-200b increases CSC formation. [Mol Cell]

Allele-Specific Copy Number Analysis of Tumors
Researchers describe a unique bioinformatics approach, ASCAT (allele-specific copy number analysis of tumors), to accurately dissect the allele-specific copy number of solid tumors, simultaneously estimating and adjusting for both tumor ploidy and nonaberrant cell admixture. [Proc Natl Acad Sci USA]

The Sympathetic Nervous System Induces a Metastatic Switch in Primary Breast Cancer
To investigate the role of neuroendocrine activation in cancer progression, researchers used in vivo bioluminescence imaging to track the development of metastasis in an orthotopic mouse model of breast cancer. [Cancer Res]

Telomerase Inhibition Potentiates the Effects of Genotoxic Agents in Breast and Colorectal Cancer Cells in a Cell Cycle Specific Manner
Here, researchers show that transient inhibition of telomerase activity by the specific inhibitor GRN163L increases the cytotoxicity of some, but not all, DNA-damaging agents. [Cancer Res]

Angiotensin-(1-7) Reduces Fibrosis in Orthotopic Breast Tumors
In this study, Ang-(1-7) inhibited the growth of cancer-associated fibroblasts and reduced fibrosis in the tumor microenvironment. [Cancer Res]

The Lymphovascular Embolus of Inflammatory Breast Cancer Exhibits a Notch 3 Addiction
The lymphovascular emboli of human inflammatory breast carcinoma exhibited dual Notch 3 intracellular domain and aldehyde dehydrogenase 1 immunoreactivities independently of molecular subtype. [Oncogene]

A Comparison of PAM50 Intrinsic Subtyping with Immunohistochemistry and Clinical Prognostic Factors in Tamoxifen-Treated Estrogen Receptor Positive Breast Cancer
The purpose of this study was to compare clinical, immunohistochemical and gene expression models of prognosis applicable to formalin-fixed, paraffin-embedded blocks in a large series of estrogen receptor positive breast cancers, from patients uniformly treated with adjuvant tamoxifen. [Clin Cancer Res]

Sphingosine 1-Phosphate Receptor 4 Uses HER2 (ErbB2) to Regulate Extracellular Signal Regulated Kinase-1/2 in MDA-MB-453 Breast Cancer Cells
Researchers demonstrate that the bioactive lipid sphingosine 1-phosphate uses the sphingosine 1-phosphate receptor 4 and human epidermal growth factor receptor 2 to stimulate the extracellular signal regulated protein kinase 1/2 pathway in MDA-MB-453 cells. [J Biol Chem]

CLINICAL RESEARCH

Evaluation of Treatment-Effect Heterogeneity Using Biomarkers Measured on a Continuous Scale: Subpopulation Treatment Effect Pattern Plot
The purpose of this article was to provide an overview of an intuitive statistical approach – the subpopulation treatment effect pattern plot (STEPP) – for evaluating treatment-effect heterogeneity when a biomarker is measured on a continuous scale. [J Clin Oncol]

A Phase I Study of Sunitinib Plus Capecitabine in Patients With Advanced Solid Tumors
This open-label, phase I, dose-escalation study assessed the maximum-tolerated dose, safety, pharmacokinetics, and antitumor activity of sunitinib in combination with capecitabine in patients with advanced solid tumors. [J Clin Oncol]

New Relationships Between Breast Microcalcifications and Cancer
This study explores the hypothesis that breast calcification composition is directly related to the local tissue pathological state. [Br J Cancer]



INDUSTRY NEWS

Maryland Stem Cell Research Commission to Host Third Annual Maryland Stem Cell Research Symposium
The Maryland Stem Cell Research Commission will host the Third Annual Maryland Stem Cell Research Symposium in partnership with the National Institutes of Health and the National Institute of Standards and Technology on Sept. 22, 2010. [Maryland Stem Cell Research Fund Press Release]

Absorption Systems Awarded Patent for CellPort Technologies
Absorption Systems announced that the US Patent and Trademark Office issued US patent number 7,795,019 covering its novel Breast Cancer Resistance Protein (BCRP) knockdown cell line within the company’s CellPort Technologies® brand. [Absorption Systems Press Release]

Roche Rules Out Merging R&D Units
Roche Holding AG is sticking to its dual-track research structure that some analysts have urged it to dismantle as the Swiss drugmaker seeks ways to slash costs after pipeline setbacks. [Reuters]



POLICY NEWS

NIH Expands Network Focused on How Genes Affect Drug Responses [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-22327) [National Institutes of Health, United States]

National Center for Research Resources; Notice of Closed Meetings (FR Doc. 2010-22529) [National Institutes of Health, United States]

Notice of Correction:  Application Due Date for RFA-HG-10-012, Revolutionary Genome Sequencing Technologies – The $1000 Genome (R01) and RFA-HG-10-013, Revolutionary Genome Sequencing Technologies – The $1000 Genome (R21) (Notice Number:NOT-HG-10-021) [National Institutes of Health, United States]

Knockout Mouse Production and Cryopreservation (U42) (RFA-RM-10-013) [National Institutes of Health, United States]

Knockout Mouse Phenotyping Project Database (U54) (RFA-RM-10-012) [National Institutes of Health, United States]

Knockout Mouse Phenotyping (U54) (RFA-RM-10-011) [National Institutes of Health, United States]

Enhancing Peer Review:  Reminder of and Correction to Previous Notice on A2 Resubmission Opportunities for Eligible Applications (NOT-OD-10-135) [National Institutes of Health, United States]

Notice of Correction to RFA-AG-11-010, Basic Research on Self-Regulation (R21) (NOT-AG-10-011) [National Institutes of Health, United States]

Agenda for the Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations [Food and Drug Administration, United States]



EVENTS (Listed by Date)

Cellular Therapy of Cancer Symposium – ATTACK Project Meeting
September 24-27, 2010
Montpellier, France

International Society for Cellular Therapy 2nd Annual Symposium on Stem Cell Translation: Best Practices & Regulatory Considerations
September 27-28, 2010
San Francisco, United States

Expert Perspectives: Integrating New Data into Best Practices for Breast Cancer
October 1, 2010
National Harbor, United States

2010 Breast Cancer Symposium
October 1-3, 2010
Washington, DC, United States

2nd International Inflammatory Breast Cancer Conference
October 6-7, 2010
Marseille, France

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

New York Stem Cell Foundation Fifth Annual Translational Stem Cell Research Meeting
October 12-13, 2010
New York, United States

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

16th World Congress of the International Society of Senology
October 20-22, 2010
Valencia, Spain

The 2010 American Institute for Cancer Research (AICR) Annual Research Conference on Food, Nutrition, Physical Activity & Cancer
October 21-22, 2010
Washington, DC, United States

MENA Oncology Conference
October 22-23, 2010
Cairo, Egypt

UAE Cancer Congress 2010
October 28-30, 2010
Dubai, United Arab Emirates

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

22nd EORTC-NCI-AACR Symposium on “Molecular Targets and Cancer Therapeutics”
November 16-19, 2010
Berlin, Germany

NEW Clinical Dilemmas in Management of Breast and Ovarian Cancer in BRCA Carriers
November 18-19, 2010
Tel Aviv, Israel

33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States

NEW 28th Annual Miami Breast Cancer Conference
March 9-12, 2011
Miami, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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