Volume 2.34 | Sep 9

Mammary Cell News 2.34 September 9, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


Scientists Make Major Discovery in Finding Origins of Aggressive Breast Cancer  ShareThis
Researchers show for the first time that the most aggressive and hard-to-treat types of breast cancer are likely to arise from intermediary, or progenitor, cells. [Press release from the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research discussing online prepublication in Cell Stem Cell]



Gambling on Breast Scans: Monte Carlo Analysis Could Help Reduce Number of Cancers Missed by Mammography
A mathematical tool known as a Monte Carlo analysis could help improve the way X-rays are used for mammography and reduce the number of breast cancers missed by the technique as well as avoiding false positives, according to research. [Press release from EurekAlert! discussing online prepublication in the International Journal of Low Radiation]

Team to Study Health Effects of Botanical Estrogens
The Botanical Research Center will draw on the expertise of a multidisciplinary team of researchers to address the many unknowns associated with use of botanical estrogens. [The University of Illinois Press Release]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)


Effect of Multikinase Inhibitors on Caspase-Independent Cell Death and DNA Damage in HER2-Overexpressing Breast Cancer Cells
Results showed that HER2 and dasatinib-sensitive tyrosine kinases act in a synergistic manner to safeguard the breast cancer cells from DNA damage. [J Natl Cancer Inst]

MI-219-Zinc Combination: A New Paradigm in MDM2 Inhibitor-Based Therapy
In this clinically translatable study, researchers explored the critical role of zinc on p53 reactivation by MDM2 inhibitor, MI-219, in colon and breast cancer cells. [Cell Res]

Antibody-Dependent Natural Killer Cell-Mediated Cytotoxicity Engendered by a Kinase-Inactive Human HER2 Adenovirus-Based Vaccination Mediates Resistance to Breast Tumors
The findings define a critical requirement for natural killer cells in vaccine-induced protection against HER2-expressing tumors. [Cancer Res]

Estrogen and Progesterone Receptor Status Affect Genome-Wide DNA Methylation Profile in Breast Cancer
Researchers performed a genome-wide DNA methylation profiling to evaluate whether the DNA methylation state is different in the estrogen receptor and progesterone receptor status of breast cancer. [Hum Mol Genet]

miR-145-Dependent Targeting of Junctional Adhesion Molecule A and Modulation of Fascin Expression are Associated with Reduced Breast Cancer Cell Motility and Invasiveness
As several predicted targets of miR-145 potentially regulate cell motility, researchers aimed at investigating a potential role for miR-145 in breast cancer cell motility and invasiveness. [Oncogene]

Benefits of Biomarker Selection and Clinico-Pathological Covariate Inclusion in Breast Cancer Prognostic Models
Researchers generated prognostic models that incorporate protein-based molecular markers and clinico-pathological variables to improve survival prediction. [Breast Cancer Res]

Phenotypic and Molecular Characterization of the Claudin-Low Intrinsic Subtype of Breast Cancer
Here, researchers comprehensively characterize the recently identified claudin-low tumor subtype. [Breast Cancer Res]


First-Line Bevacizumab Plus Taxane-Based Chemotherapy for Locally Recurrent or Metastatic Breast Cancer: Safety and Efficacy in an Open-Label Study in 2251 Patients
First-line bevacizumab combined with chemotherapy significantly improves efficacy versus chemotherapy alone in human epidermal growth factor receptor 2 (HER2)-negative locally recurrent or metastatic breast cancer (LR/mBC). This large, open-label study further assesses first-line bevacizumab with taxane-based chemotherapy in routine oncology practice. [Ann Oncol]

Meta-Analysis of the Impact of Surgical Margins on Local Recurrence in Women with Early-Stage Invasive Breast Cancer Treated with Breast-Conserving Therapy
Meta-analysis of studies reporting local recurrence relative to quantified final microscopic margin status and the threshold distance for negative margins. [Eur J Cancer]

Mammography Image Quality Optimisation: A Monte Carlo Study
Different irradiation configurations for typical mammographic facilities were evaluated in order to establish optimal irradiation parameters for improving X-ray image quality. [Int J Low Radiation]


Roche Announces Operational Excellence Initiative
Roche announced the launch of a Group-wide Operational Excellence initiative. In view of mounting pressures to curb healthcare costs – especially in the United States and Europe – together with recent developments in late-stage projects in the Roche pipeline, this initiative aims to adapt cost structures and accelerate productivity improvements Group-wide. [Hoffmann-La Roche Ltd. Press Release]


NIH Orders Immediate Shutdown of Intramural Human Embryonic Stem Cell Research
Responding to a court order, the National Institutes of Health (NIH) ordered intramural researchers studying human embryonic stem cells to shut down their experiments. [National Institutes of Health, United States]

Obama Administration Appeals Stem Cell Injunction
The Obama administration asked a federal judge to lift an injunction halting human embryonic stem cell research, saying it would irreparably harm research and cost more than 1,300 jobs. [The White House, United States]

Appeals Court Stays Stem Cell Injunction
A federal appeals court stayed, or suspended, a preliminary injunction issued 2 weeks ago that brought federal funding for human embryonic stem cell (hESC) research to a standstill. [Court of Appeals, United States]

Medical School Leaders Express Support for Stem Cell Research in New AAMC Ad [Association of American Medical Colleges, United States]

Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society (FR Doc. 2010-21532) [Department of Health and Human Services, United States]

Findings of Research Misconduct (NOT-OD-10-132) [Department of Health and Human Services, United States]

Protein Structure Initiative:Biology-Materials Repository (PSI:Biology-MR) (U01) (RFA-GM-11-008) [National Institute of General Medical Sciences, United States]

Developing and Improving Institutional Animal Resources (G20) (RFA-RR-10-011) [National Center for Research Resources, United States]

Status of Applications and Awards Involving Human Embryonic Stem Cells, and Submissions of Stem Cell Lines for Eligibility Consideration (NOT-OD-10-126) [National Institutes of Health, United States]

Clarification on the Roles of NIH Scientific Review Groups (SRG) and Institutional Animal Care and Use Committees (IACUC) in Review of Vertebrate Animal Research (NOT-OD-10-128) [National Institutes of Health, United States]

Clarification of Eligible Institutions for PA-10-050: Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-21816) [National Institutes of Health, United States]

EVENTS (Listed by Date)

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

Cellular Therapy of Cancer Symposium – ATTACK Project Meeting
September 24-27, 2010
Montpellier, France

International Society for Cellular Therapy 2nd Annual Symposium on Stem Cell Translation: Best Practices & Regulatory Considerations
September 27-28, 2010
San Francisco, United States

Expert Perspectives: Integrating New Data into Best Practices for Breast Cancer
October 1, 2010
National Harbor, United States

2010 Breast Cancer Symposium
October 1-3, 2010
Washington, DC, United States

2nd International Inflammatory Breast Cancer Conference
October 6-7, 2010
Marseille, France

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

New York Stem Cell Foundation Fifth Annual Translational Stem Cell Research Meeting
October 12-13, 2010
New York, United States

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

16th World Congress of the International Society of Senology
October 20-22, 2010
Valencia, Spain

The 2010 American Institute for Cancer Research (AICR) Annual Research Conference on Food, Nutrition, Physical Activity & Cancer
October 21-22, 2010
Washington, DC, United States

MENA Oncology Conference
October 22-23, 2010
Cairo, Egypt

UAE Cancer Congress 2010
October 28-30, 2010
Dubai, United Arab Emirates

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

22nd EORTC-NCI-AACR Symposium on “Molecular Targets and Cancer Therapeutics”
November 16-19, 2010
Berlin, Germany

33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Cell Therapy Technologist (Opexa Therapeutics)

Recruit Top Talent
Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News.
Visit here to post your career opportunities.

Have we missed an important article or publication in Mammary Cell News? Click here to submit!

Comments or Suggestions? Email [email protected] with your feedback.

Learn more about Mammary Cell News: Archives  |  Events  |  Subscribe  |  Contact Us