Volume 2.34 | Sep 9

Mammary Cell News 2.34 September 9, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


TOP STORY

Scientists Make Major Discovery in Finding Origins of Aggressive Breast Cancer  ShareThis
Researchers show for the first time that the most aggressive and hard-to-treat types of breast cancer are likely to arise from intermediary, or progenitor, cells. [Press release from the Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research discussing online prepublication in Cell Stem Cell]

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SCIENCE NEWS

Gambling on Breast Scans: Monte Carlo Analysis Could Help Reduce Number of Cancers Missed by Mammography
A mathematical tool known as a Monte Carlo analysis could help improve the way X-rays are used for mammography and reduce the number of breast cancers missed by the technique as well as avoiding false positives, according to research. [Press release from EurekAlert! discussing online prepublication in the International Journal of Low Radiation]

Team to Study Health Effects of Botanical Estrogens
The Botanical Research Center will draw on the expertise of a multidisciplinary team of researchers to address the many unknowns associated with use of botanical estrogens. [The University of Illinois Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Effect of Multikinase Inhibitors on Caspase-Independent Cell Death and DNA Damage in HER2-Overexpressing Breast Cancer Cells
Results showed that HER2 and dasatinib-sensitive tyrosine kinases act in a synergistic manner to safeguard the breast cancer cells from DNA damage. [J Natl Cancer Inst]

MI-219-Zinc Combination: A New Paradigm in MDM2 Inhibitor-Based Therapy
In this clinically translatable study, researchers explored the critical role of zinc on p53 reactivation by MDM2 inhibitor, MI-219, in colon and breast cancer cells. [Cell Res]

Antibody-Dependent Natural Killer Cell-Mediated Cytotoxicity Engendered by a Kinase-Inactive Human HER2 Adenovirus-Based Vaccination Mediates Resistance to Breast Tumors
The findings define a critical requirement for natural killer cells in vaccine-induced protection against HER2-expressing tumors. [Cancer Res]

Estrogen and Progesterone Receptor Status Affect Genome-Wide DNA Methylation Profile in Breast Cancer
Researchers performed a genome-wide DNA methylation profiling to evaluate whether the DNA methylation state is different in the estrogen receptor and progesterone receptor status of breast cancer. [Hum Mol Genet]

miR-145-Dependent Targeting of Junctional Adhesion Molecule A and Modulation of Fascin Expression are Associated with Reduced Breast Cancer Cell Motility and Invasiveness
As several predicted targets of miR-145 potentially regulate cell motility, researchers aimed at investigating a potential role for miR-145 in breast cancer cell motility and invasiveness. [Oncogene]

Benefits of Biomarker Selection and Clinico-Pathological Covariate Inclusion in Breast Cancer Prognostic Models
Researchers generated prognostic models that incorporate protein-based molecular markers and clinico-pathological variables to improve survival prediction. [Breast Cancer Res]

Phenotypic and Molecular Characterization of the Claudin-Low Intrinsic Subtype of Breast Cancer
Here, researchers comprehensively characterize the recently identified claudin-low tumor subtype. [Breast Cancer Res]

CLINICAL RESEARCH

First-Line Bevacizumab Plus Taxane-Based Chemotherapy for Locally Recurrent or Metastatic Breast Cancer: Safety and Efficacy in an Open-Label Study in 2251 Patients
First-line bevacizumab combined with chemotherapy significantly improves efficacy versus chemotherapy alone in human epidermal growth factor receptor 2 (HER2)-negative locally recurrent or metastatic breast cancer (LR/mBC). This large, open-label study further assesses first-line bevacizumab with taxane-based chemotherapy in routine oncology practice. [Ann Oncol]

Meta-Analysis of the Impact of Surgical Margins on Local Recurrence in Women with Early-Stage Invasive Breast Cancer Treated with Breast-Conserving Therapy
Meta-analysis of studies reporting local recurrence relative to quantified final microscopic margin status and the threshold distance for negative margins. [Eur J Cancer]

Mammography Image Quality Optimisation: A Monte Carlo Study
Different irradiation configurations for typical mammographic facilities were evaluated in order to establish optimal irradiation parameters for improving X-ray image quality. [Int J Low Radiation]



INDUSTRY NEWS

Roche Announces Operational Excellence Initiative
Roche announced the launch of a Group-wide Operational Excellence initiative. In view of mounting pressures to curb healthcare costs – especially in the United States and Europe – together with recent developments in late-stage projects in the Roche pipeline, this initiative aims to adapt cost structures and accelerate productivity improvements Group-wide. [Hoffmann-La Roche Ltd. Press Release]



POLICY NEWS

NIH Orders Immediate Shutdown of Intramural Human Embryonic Stem Cell Research
Responding to a court order, the National Institutes of Health (NIH) ordered intramural researchers studying human embryonic stem cells to shut down their experiments. [National Institutes of Health, United States]

Obama Administration Appeals Stem Cell Injunction
The Obama administration asked a federal judge to lift an injunction halting human embryonic stem cell research, saying it would irreparably harm research and cost more than 1,300 jobs. [The White House, United States]

Appeals Court Stays Stem Cell Injunction
A federal appeals court stayed, or suspended, a preliminary injunction issued 2 weeks ago that brought federal funding for human embryonic stem cell (hESC) research to a standstill. [Court of Appeals, United States]

Medical School Leaders Express Support for Stem Cell Research in New AAMC Ad [Association of American Medical Colleges, United States]

Notice of Meeting: Secretary’s Advisory Committee on Genetics, Health, and Society (FR Doc. 2010-21532) [Department of Health and Human Services, United States]

Findings of Research Misconduct (NOT-OD-10-132) [Department of Health and Human Services, United States]

Protein Structure Initiative:Biology-Materials Repository (PSI:Biology-MR) (U01) (RFA-GM-11-008) [National Institute of General Medical Sciences, United States]

Developing and Improving Institutional Animal Resources (G20) (RFA-RR-10-011) [National Center for Research Resources, United States]

Status of Applications and Awards Involving Human Embryonic Stem Cells, and Submissions of Stem Cell Lines for Eligibility Consideration (NOT-OD-10-126) [National Institutes of Health, United States]

Clarification on the Roles of NIH Scientific Review Groups (SRG) and Institutional Animal Care and Use Committees (IACUC) in Review of Vertebrate Animal Research (NOT-OD-10-128) [National Institutes of Health, United States]

Clarification of Eligible Institutions for PA-10-050: Omnibus Solicitation of the NIH, CDC, FDA and ACF for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44]) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-21816) [National Institutes of Health, United States]



EVENTS (Listed by Date)

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

Cellular Therapy of Cancer Symposium – ATTACK Project Meeting
September 24-27, 2010
Montpellier, France

International Society for Cellular Therapy 2nd Annual Symposium on Stem Cell Translation: Best Practices & Regulatory Considerations
September 27-28, 2010
San Francisco, United States

Expert Perspectives: Integrating New Data into Best Practices for Breast Cancer
October 1, 2010
National Harbor, United States

2010 Breast Cancer Symposium
October 1-3, 2010
Washington, DC, United States

2nd International Inflammatory Breast Cancer Conference
October 6-7, 2010
Marseille, France

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

New York Stem Cell Foundation Fifth Annual Translational Stem Cell Research Meeting
October 12-13, 2010
New York, United States

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

16th World Congress of the International Society of Senology
October 20-22, 2010
Valencia, Spain

The 2010 American Institute for Cancer Research (AICR) Annual Research Conference on Food, Nutrition, Physical Activity & Cancer
October 21-22, 2010
Washington, DC, United States

MENA Oncology Conference
October 22-23, 2010
Cairo, Egypt

UAE Cancer Congress 2010
October 28-30, 2010
Dubai, United Arab Emirates

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

22nd EORTC-NCI-AACR Symposium on “Molecular Targets and Cancer Therapeutics”
November 16-19, 2010
Berlin, Germany

33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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