Volume 2.31 | Aug 19

Mammary Cell News 2.31 August 19, 2010.
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Beta1-Integrin is Dispensable for the Induction of ErbB2 Mammary Tumors but Plays a Critical Role in the Metastatic Phase of Tumor Progression  ShareThis
Previous studies with a polyomavirus middle T mammary tumor model have indicated that targeted disruption of beta1-integrin in the mammary glands of these mice completely blocks tumor induction. To further explore the general significance of these observations, researchers crossed these conditional beta1-integrin strains to a strain of mice carrying mouse mammary tumor virus/activated erbB2. [Proc Natl Acad Sci USA]

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UK Breast Cancer Mortality Rates Have Fallen Faster Than in Other European Countries, Study Finds
Population-based breast cancer mortality rates in the United Kingdom (UK) have fallen steeply in the last two decades — more than in any other major European country, finds a study. [Press release from ScienceDaily discussing online prepublication in the British Medical Journal]

Stark Differences in Global Breast Cancer Rates Underscore Role of US Lifestyle in Risk, Say Experts
Breast cancer rates in the United States are nearly double those seen in South American countries like Brazil, and experts said that differences in diet, weight and physical activity are important reasons why. [American Institute for Cancer Research Press Release]

CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)


Core Epithelial-to-Mesenchymal Transition Interactome Gene-Expression Signature is Associated with Claudin-Low and Metaplastic Breast Cancer Subtypes
The epithelial-to-mesenchymal transition (EMT) core signature associates closely with the claudin-low and metaplastic breast cancer subtypes and correlates negatively with pathological complete response. Additionally, the expression level of FOXC1, another EMT inducer, correlates strongly with poor survival of breast cancer patients. [Proc Natl Acad Sci USA]

A Rac-Pak Signaling Pathway is Essential for ErbB2-Mediated Transformation of Human Breast Epithelial Cancer Cells
In this study, scientists asked if ErbB2 expression correlates with p21-activated kinase-1 (Pak1) and extracellular signal-regulated kinase activity in human breast cancer specimens, and if Pak1 signaling is required for ErbB2 transformation in a three-dimensional in vitro setting and in xenografts. [Oncogene]

Nox4-Dependent Ros Production by Stromal Mammary Cells Modulates Epithelial MCF-7 Cell Migration
In this work, investigators studied the influence of epithelial cells on the stromal redox status and the consequence of this phenomenon on MCF-7 cell motility. [Br J Cancer]

The Embryonic Transcription Cofactor LBH is a Direct Target of the Wnt Signaling Pathway in Epithelial Development and in Aggressive Basal Subtype Breast Cancers
Here researchers show that in epithelial development, limb-bud and heart (LBH) expression is tightly controlled by Wnt signaling. [Mol Cell Bio]

CD36-Mediated Activation of Endothelial Cell Apoptosis by an N-Terminal Recombinant Fragment of Thrombospondin-2 Inhibits Breast Cancer Growth and Metastasis In Vivo
Scientists generated a recombinant fusion protein consisting of the N-terminal region of thrombospondin-2 (TSP-2) and the IgG-Fc1 fragment (N-TSP2-Fc) and could demonstrate that the antiangiogenic activity of N-TSP2-Fc is dependent on the CD36 receptor. [Breast Cancer Res Treat]

Loss, Mutation and Deregulation of L3MBTL4 in Breast Cancers
Investigators studied 307 primary breast tumors and 47 breast cancer cell lines by high resolution array comparative genomic hybridization. They identified a region on 18p11.31 lost in about 20% of the tumors and 40% of the cell lines. [Mol Cancer]

Native Type IV Collagen Induces Cell Migration Through a CD9 and DDR1-Dependent Pathway in MDA-MB-231 Breast Cancer Cells
Researchers demonstrated here that native type IV collagen induces a transient increase of CD9-cell surface levels through a DDR1-dependent pathway in MDA-MB-231 breast cancer cells, as revealed by flow cytometry and Western blotting using specific antibodies that recognize CD9. [Eur J Cell Biol]

SLUG/SNAI2 and Tumor Necrosis Factor Generate Breast Cells with CD44+/CD24- Phenotype
Scientists hypothesized that only a subset of genes associated with epithelial-to-mesenchymal transition generates CD44+/CD24- cells. [BMC Cancer]


Disparities in Breast Cancer Mortality Trends Between 30 European Countries: Retrospective Trend Analysis of WHO Mortality Database
The objective of this study was to examine changes in temporal trends in breast cancer mortality in women living in 30 European countries. [Br Med J]

Case-Control Study of Body Size and Breast Cancer Risk in Nigerian Women
The authors assessed the association between breast cancer and anthropometric measures in the Nigerian Breast Cancer Study (Ibadan, Nigeria). [Am J Epidemiol]

Breast Cancer Patients’ Clinical Outcome Measures are Associated with Src Kinase Family Member Expression
This study determined mRNA expression levels for Src kinase family (SFK) members in breast tissue specimens and assessed protein expression levels of prominent SFK members in invasive breast cancer to establish associations with clinical outcome. [Br J Cancer]


ICT Research: EU Funded Clinical Workstation will Help Accurately Detect Breast Cancer
The European Union (EU) is investing 3.1 million euros to develop better and quicker breast cancer diagnostics through the HAMAM project. [European Union Press Release]

Pfizer Wins Jury Verdict in Prempro Litigation
Pfizer Inc. said a jury in Pennsylvania state court found that the hormone-therapy drug Prempo didn’t cause breast cancer in two women. [The Wall Street Journal]

Breast Tissue Model to Aid Research
University of Ulster researchers are to develop a 3D model of breast tissue using human cells, to examine some of the potential causes of breast cancer. The researchers at the Biomedical Sciences Research Institute received £360,000 funding from The National Centre for the Replacement, Refinement and Reduction of Animals in Research to carry out the project, which will develop a model of human tissue to explore breast cancer, rather than the current animal testing carried out. [University of Ulster Press Release]

International Recognition for IUPUI Work to Improve Breast Cancer Detection
A paper describing the development of a new methodology to improve identification of breast cancer tissue by pathology laboratories has been selected as the best scientific paper in the “bioinformatics and biomedical applications track” by the International Association for Pattern Recognition. [Indiana University-Purdue University Indianapolis (IUPUI) Press Release]

UA Researcher Awarded Patent for Breast Cancer Drug Breakthrough
Joyce A. Schroeder, an associate professor in the department of molecular and cellular biology at the University of Arizona (UA), has been awarded a U.S. patent for a first-in-class breast cancer treatment. [University of Arizona Press Release]

Cancer Research UK Researchers Honoured By Leading Science Bodies
Two Cancer Research UK scientists were recently awarded prestigious Royal Society Awards, while a number of Cancer Research UK scientists were elected fellows of the Royal Society and the Academy of Medical Sciences. [Cancer Research UK Press Release]


NICE Announces Development of Further Quality Standards
National Institute for Health and Clinical Excellence (NICE) announced nine new quality standards that it will develop during 2010/11. These were referred to NICE from the Department of Health following advice from the National Quality Board. [National Institute for Health and Clinical Excellence, United Kingdom]

Human Genetics Commission Sets New Standards for Direct-to-Consumer Genetic Tests
The Common Framework of Principles for direct-to-consumer genetic testing services, published by the Human Genetics Commission, aims to ensure that people who choose to buy genetic tests themselves can have confidence that the companies selling them follow basic principles of consent, data protection, truth in marketing, scientific rigor and balanced interpretation. [Human Genetics Commission, United Kingdom]

EU Agency Allows Access to Drug Side Effects Data
The European Medicines Agency has agreed to provide access to studies about drug side effects, following criticism over data secrecy from the European Ombudsman. [European Medicines Agency, European Union]

University of California, Berkeley Alters DNA Testing Program
The California Department of Public Health has instructed the University of California, Berkeley, not to proceed with a portion of its ground-breaking program to educate students about genetic testing and personalized medicine. [California Department of Public Health, United States]

New Breast Cancer Committee to Establish Federal Research Agenda
A newly formed advisory committee will develop and coordinate a strategic federal research agenda on environmental and genetic factors related to breast cancer. [Interagency Breast Cancer and Environmental Research Coordinating Committee, United States]

FDA Considers Revoking Approval of Avastin for Advanced Breast Cancer
Federal regulators are considering taking the highly unusual step of rescinding approval of a drug that patients with advanced breast cancer turn to as a last-ditch hope. [Food and Drug Administration, United States]

Comprehensive List of Guidance Documents at the Food and Drug Administration [Docket No. FDA-1998-N-0050] (formerly Docket No. 1998N-0046) [Food and Drug Administration, United States]

Proposed Collection; Comment Request; NIH NCI Central Institutional Review Board (CIRB) Initiative (NCI) (FR Doc. 2010-20167) [National Institutes of Health, United States]

Center for Scientific Review, Notice of Closed Meetings (FR Doc. 2010- 20044) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20021) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-19939) [National Institutes of Health, United States]

7342.007 Addendum – Imported Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) [Center for Biologics Evaluation and Research, United States]

EVENTS (Listed by Date)

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Clinical Trials International Summit 2010
September 1-2, 2010
Pudong, China

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

Cellular Therapy of Cancer Symposium – ATTACK Project Meeting
September 24-27, 2010
Montpellier, France

International Society for Cellular Therapy 2nd Annual Symposium on Stem Cell Translation: Best Practices & Regulatory Considerations
September 27-28, 2010
San Francisco, United States

Expert Perspectives: Integrating New Data into Best Practices for Breast Cancer
October 1, 2010
National Harbor, United States

2010 Breast Cancer Symposium
October 1-3, 2010
Washington, DC, United States

2nd International Inflammatory Breast Cancer Conference
October 6-7, 2010
Marseille, France

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

New York Stem Cell Foundation Fifth Annual Translational Stem Cell Research Meeting
October 12-13, 2010
New York, United States

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

16th World Congress of the International Society of Senology
October 20-22, 2010
Valencia, Spain

The 2010 American Institute for Cancer Research (AICR) Annual Research Conference on Food, Nutrition, Physical Activity & Cancer
October 21-22, 2010
Washington, DC, United States

MENA Oncology Conference
October 22-23, 2010
Cairo, Egypt

UAE Cancer Congress 2010
October 28-30, 2010
Dubai, United Arab Emirates

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

22nd EORTC-NCI-AACR Symposium on “Molecular Targets and Cancer Therapeutics”
November 16-19, 2010
Berlin, Germany

33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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