Volume 2.30 | Aug 12

Mammary Cell News 2.30 August 12, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe


TOP STORY

Mechanisms of Estrogen Receptor Antagonism toward p53 and its Implications in Breast Cancer Therapeutic Response and Stem Cell Regulation  ShareThis
Here, scientists reported on the molecular mechanisms by which estrogen receptor-alpha suppresses p53’s transactivation function. [Proc Natl Sci USA]


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SCIENCE NEWS

Endocrine Sensitivity Measure Predicts Breast Cancer Survival
A patient’s sensitivity to endocrine therapy index, a measure of estrogen receptor-related transcription activity, appears to be predictive of distant relapse-free survival in breast cancer patients who receive endocrine therapy alone or endocrine therapy after chemotherapy, but not in those who receive no adjuvant therapy. [Press release from ModernMedicine discussing online prepublication in the Journal of Clinical Oncology]

No Benefit from Infusional Chemotherapy in Early Breast Cancer
For patients with early-stage breast cancer, adjuvant treatment with intravenous epirubicin, cisplatin, and 5-fluorouracil shows no benefit in terms of reducing relapse rates over 5-fluorouracil, epirubicin, and cyclophosphamide. [Press release from MedWire News discussing online prepublication in Annals of Oncology]

Breast Cancer Risk Varies Among Different Progestins Used in Hormone Replacement Therapy
Researchers compared four types of progestins used in hormone replacement therapies and found significantly different outcomes on the progression of breast cancer in an animal model depending on the type of progestin used. [Press release from EurekAlert! discussing online prepublication in Cancer Prevention Research]

Postmenopausal Therapy Poses Risk for Breast Cancer
Using postmenopausal hormone therapy for more than 15 years increases a woman’s risk of developing breast cancer, particularly among leaner women. [Press release from the University of Southern California discussing online prepublication in Cancer Epidemiology, Biomarkers and Prevention]

K-State Research Team Investigates Mutated Gene’s Role in Breast Cancer
A microscopic gene may play a gigantic role when it comes to cancerous tissue in the human body. The team is investigating mutations within the ADAM12 gene of the A Disintegrin and Metalloprotease family, or ADAM family, and its role in breast cancer. [Kansas State University Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

The Protein Kinase Pak4 Disrupts Mammary Acinar Architecture and Promotes Mammary Tumorigenesis
In this study investigators used immortalized mouse mammary epithelial cells as a model system to study the role for Pak4 in mammary tumorigenesis. [Oncogene]

Evi dence for a Pro-Apoptotic Function of RACK1 in Human Breast Cancer
Scientists have recently conducted an analysis of RACK1 messenger RNA expression in 127 human breast cancer and 33 non-cancerous breast tissue specimens. [Oncogene]

Synthetic Progestins Differentially Promote or Prevent 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Sprague-Dawley Rats
The goal of this study was to compare the effects of four clinically relevant progestins, medroxyprogesterone acetate, norgestrel, norethindrone, and megestrol acetate, on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in the rat. [Cancer Prev Res]

Genetic Manipulation of Individual Somatic Mammary Cells In Vivo Reveals a Master Role of S TAT5a in Inducing Alveolar Fate Commitment and Lactogenesis in the Absence of Reproductive Hormones
By exploiting an intraductal retrovirus-mediated gene delivery method to introduce a marker gene, researchers found that ductal epithelial cells are turned over with a half time of approximately one month in adult virgin mice. [Dev Biol]

Redefining the Expression and Function of the Inhibitor of Differentiation 1 in Mammary Gland Development
Generation and analysis of a transgenic mouse model of Inhibitor of Differentiation 1 (Id1) overexpression in the mammary gland reveals that Id1 is insufficient for neoplastic progression in virgin animals or to prevent terminal differentiation of the luminal epithelia during pregnancy and lactation. Together, these data demonstrated that there is no luminal cell-autonomous role for Id1 in mammary epithelial cell fate determination, ductal morphogenesis and terminal differentiation. [PLoS One]

Transforming Growth Factor-Beta 1-Mediated Activation of NF-Kappa B Contributes to Enhanced ADAM-12 Expression in Mammary Carcinoma Cells
The study identified a cellular mechanism for induction of A disintegrin and metalloproteinase-12 (ADAM-12), which involves nuclear factor-kappa B (NF-kappa B) and its activation by transforming growth factor-beta 1 (TGF-beta1). [Mol Cancer Res]

CLINICAL RESEARCH

Genomic Index of Sensitivity to Endocrine Therapy for Breast Cancer
Scientists hypothesized that measurement of gene expression related to estrogen receptor-alpha (ESR1) within a breast cancer sample represents intrinsic tumoral sensitivity to adjuvant endocrine therapy. [J Clin Oncol]

A Randomised Comparative Trial of Infusional ECisF Versus Conventional FEC as Adjuvant Chemotherapy in Early Breast Cancer: The TRAFIC Trial
In this multicentre, open-label, phase III randomised controlled trial, 349 women were randomly assigned to receive i.v. ECisF [epirubicin 60 mg/m(2), day 1, cisplatin 60 mg/m(2), day 1 and 5-FU 200 mg/m(2) by daily 24-h infusion (n = 172)] or FEC [5-FU 600 mg/m(2), day 1, epirubicin 60 mg/m(2), day 1 and cyclophosphamide 600 mg/m(2), day 1 (n = 177)]. [Ann Oncol]

Menopausal Hormone Therapy and Subsequent Risk of Specific Invasive Breast Cancer Subtypes in the California Teachers Study
Researchers investigated hormone therapy use in relation to breast cancer risk in the California Teachers Study cohort. [Cancer Epidemiol Biomarkers Prev]




INDUSTRY NEWS

Orbital Therapy Receives Patent for a Self-Shielded Radiotherapy Device
Orbital Therapy was issued a U.S. patent 7,758,241 for a self-shielded radiotherapy device, not requiring a traditional bunker for operation. [Orbital Therapy, LLC Press Release]

K-State Professor’s Cancer Research gets Boost from National Institutes of Health
Annelise Nguyen recently received a $370,000 grant from the National Institutes of Health to continue her cancer research. [Kansas State (K-State) University Press Release]

Funding Supports Study of Breast Cancer Gene Mutation
A team of Queen’s University researchers has received $450,000 to study a gene mutation common to breast cancer patients. The three-year funding supports research aimed at developing an inexpensive diagnostic tool for identifying individuals with the gene mutation. [Queen’s University Press Release]

Komen Grant Supports Research into Suspicious Gene Tied to Breast Cancer
Armed with an award from the Susan G. Komen for the Cure®, Catherine Denicourt is studying a suspicious gene tied to increased risk of malignant breast cancer. [Press release from The University of Texas Health Science Center]

Fred Hutchinson Cancer Research Center Announces Selection of its New President and Director
The Fred Hutchinson Cancer Research Center board of trustees announced the selection of Lawrence Corey as its new president and director. [Fred Hutchinson Cancer Research Center Press Release]

Craig Thompson Named President of Memorial Sloan-Kettering Cancer Center
Craig B. Thompson has been named the new President and Chief Executive Officer of Memorial Sloan-Kettering Cancer Center effective November 2, 2010. [Memorial Sloan-Kettering Cancer Center Press Release]

IU Physician Receives Funding for Rare, Aggressive Breast Cancer Research
Bryan Schneider and doctoral student Milan Radovich will study the underlying molecular underpinning of inflammatory breast cancer using cutting edge technology called Next Generation Sequencing with the support of a $50,000 grant from the Inflammatory Breast Cancer Research Foundation and the Milburn Foundation partnership. [Indiana University (IU) Press Release]

Roswell Park Cancer Institute Explores Research Collaboration with Wilmot Cancer Center
Roswell Park Cancer Institute and The University of Rochester Medical Center’s James P. Wilmot Cancer Center announced that they are exploring a regional scientific alliance. [Roswell Park Cancer Institute Press Release]




POLICY NEWS

Information Sent to Healthcare Professionals in July 2010 About the Safety of Medicines
A list of letters sent to healthcare professionals in July 2010, to inform of new safety information and advice about medicines. [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

Adverse Drug Reactions: Update on Anonymized Single Patient Reports (ASPRs): July 2010
The MHRA has implemented a series of changes to the logic which defines which marketing authorization holders receive ASPRs/Individual Case Safety Reports. [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

Georgetown U. Hospital Closes Lab After Problems with Breast Cancer Tests
Georgetown University Hospital has shut down a lab that performs genetic analysis for breast cancer patients and has had 249 women’s tissue samples independently retested while federal health officials investigate procedures at the lab. [Georgetown University Hospital, United States]

Scientists Decry Proposed Ban on Chimp Research
In the latest twist in the protracted debate over the use of chimpanzees in biomedical research, U.S. senators introduced the Great Ape Protection Act, an identical bill to one that has been stuck in a House of Representatives committee for more than a year. [Senate, United States]

Solicitation for Nominations: New Clinical Preventive Health for the United States Preventive Services Task Force, [2010-19117]  [Agency for Healthcare Research and Quality, United States]

Chimpanzee Biomedical Research Program Limited Competition (U42) (RFA-RR-10-008) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-19167) [National Institutes of Health, United States]

National Human Genome Research Institute; Notice of Meeting (FR Doc. 2010-19165) [National Institutes of Health, United States]

2010 Biological License Application Approvals [Center for Biologics Evaluation and Research, United States]

2010 Biological License Application Supplement Noteworthy Approvals [Center for Biologics Evaluation and Research, United States]

2010 Biological Device Application Approvals [Center for Biologics Evaluation and Research, United States]

Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Administrative Procedures for the Clinical Laboratory Improvement Amendments of 1988 Categorization [Docket No. FDA-2010-N-0199] [Food and Drug Administration, United States]

Clinical Studies of Safety and Effectiveness of Orphan Products Research Project Grant (R01) [Docket No. FDA-2010-N-0394] [Food and Drug Administration, United States]

Guidance for Industry on Drug Substance Chemistry, Manufacturing, and Controls Information; Availability [Docket No. FDA-2003-D-0243] [Food and Drug Administration, United States]




EVENTS (Listed by Date)

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

Cellular Therapy of Cancer Symposium – ATTACK Project Meeting
September 24-27, 2010
Montpellier, France

NEW International Society for Cellular Therapy 2nd Annual Symposium on Stem Cell Translation: Best Practices & Regulatory Considerations
September 27-28, 2010
San Francisco, United States

Expert Perspectives: Integrating New Data into Best Practices for Breast Cancer
October 1, 2010
National Harbor, United States

2010 Breast Cancer Symposium
October 1-3, 2010
Washington, DC, United States

2nd International Inflammatory Breast Cancer Conference
October 6-7, 2010
Marseille, France

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

NEW New York Stem Cell Foundation Fifth Annual Translational Stem Cell Research Meeting
October 12-13, 2010
New York, United States

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

16th World Congress of the International Society of Senology
October 20-22, 2010
Valencia, Spain

The 2010 American Institute for Cancer Research (AICR) Annual Research Conference on Food, Nutrition, Physical Activity & Cancer
October 21-22, 2010
Washington, DC, United States

MENA Oncology Conference
October 22-23, 2010
Cairo, Egypt

UAE Cancer Congress 2010
October 28-30, 2010
Dubai, United Arab Emirates

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom

22nd EORTC-NCI-AACR Symposium on “Molecular Targets and Cancer Therapeutics”
November 16-19, 2010
Berlin, Germany

33rd Annual San Antonio Breast Cancer Symposium
December 8-12, 2010
San Antonio, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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