Volume 2.26 | Jul 15

Mammary Cell News 2.26 July 15, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Mammosphere-Forming Cells From Breast Cancer Cell Lines as a Tool for the Identification of CSC-Like and Early Progenitor-Targeting Drugs  ShareThis
Researchers show that a subpopulation of MCF-7 breast cancer cells which stains pale to Toluidine Blue (Light Cells- LCs), is endowed with features of cancer stem cells (CSCs). LCs give rise to self-renewing mammospheres and express typical CSC markers; moreover this subpopulation is chemoresistant and highly tumorigenic in vivo. [Cell Cycle]

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SCIENCE NEWS

A*STAR Scientists Made Three Separate Groundbreaking Discoveries in the Fight Against Cancer
Scientists have made three successive breakthroughs in key areas of cancer research. Their work, published in top scientific journals Cancer Cell, Nature Cell Biology, and Cancer Research, sheds light on the mechanism behind cancer metastasis, suggest why breast cancer cells live as long as they do, and show a better way to detect and fight cervical cancer. [Press release from Singapore’s for Agency of Science, Technology and Research discussing online prepublication in Cancer Cell]

Newly Discovered Protein Function Linked to Breast Cancer
UA researchers participated in the discovery of an unexpected role played by a protein molecule, making it a candidate for a biomarker or drug target for breast cancer. [Press release from the University of Arizona discussing online prepublication in Nature Cell Biology]

New Arsenic Nanoparticle Blocks Aggressive Breast Cancer
Researchers took a drug therapy proven for blood cancers but ineffective against solid tumors, packaged it with nanotechnology and got it to combat an aggressive type of breast cancer prevalent in young women, particularly young African-American women. [Press release from Northwestern University discussing online prepublication in Clinical Cancer Research]

Newly Developed Prediction Tool Helps Estimate Local Recurrence in Patients with Non-Invasive Breast Cancer
The decision regarding treatment following breast-conserving surgery for patients diagnosed with ductal carcinoma in-situ (DCIS) has long been an area of discussion and confusion for patients and physicians alike. Researchers are reporting the development of a new prediction tool that calculates a patient’s individualized risk for recurrence five and ten years after surgery. [Press release from the Memorial Sloan-Kettering Cancer Center discussing online prepublication in the Journal of Clinical Oncology]

Scientists Reprogram Triple-Negative Breast Cancer Cells to Respond to Tamoxifen
Using a small molecule decoy, investigators have managed to block protein interactions and induce epigenetic reprogramming in human and mouse breast cancer cells, essentially changing the gene expression of breast cancer cells to behave in a more normal manner. [Press release from the Samuel Waxman Cancer Research Foundation discussing online prepublication in Proceedings of the National Academy of Sciences of the United States of America]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase
Overexpression of phosphatase of regenerating liver (PRL)-3 is associated with the progression of diverse human cancers. Researchers show that the overexpression of PRL-3 protein is not directly associated with its transcript levels, indicating the existence of an underlying posttranscriptional regulation. [Cancer Cell]

Telomere-Independent Rap1 is an IKK Adaptor and Regulates NF-(Kappa)B-Dependent Gene Expression
Researchers describe a genome-wide gain-of-function screen for regulators of NF-(kappa)B, and identify Rap1 (Trf2IP), as an essential modulator of NF-(kappa)B-mediated pathways. [Nat Cell Biol]

Monomeric Type I and Type III Transforming Growth Factor-(Beta) Receptors and Their Dimerization Revealed by Single-Molecule Imaging
Using single-molecule microscopy to image green fluorescent protein-labeled membrane proteins, for the first time researchers have demonstrated that T(beta)RI and T(beta)RIII could exist as monomers at a low expression level. [Cell Res]

A Novel Nanoparticulate Formulation of Arsenic Trioxide with Enhanced Therapeutic Efficacy in a Murine Model of Breast Cancer
The clinical success of arsenic trioxide (As2O3) in hematologic malignancies has not been replicated in solid tumors due to poor pharmacokinetics and dose-limiting toxicity. Researchers have developed a novel nanoparticulate formulation of As2O3 encapsulated in liposomal vesicles or “nanobins” [(NB(Ni,As)] to overcome these hurdles. [Clin Cancer Res]

Breast Carcinoma Cells Re-Express E-Cadherin During Mesenchymal to Epithelial Reverting Transition
Researchers first examined E-cadherin expression in primary breast tumors and their corresponding metastases to liver, lung and brain and discovered that 62% (10/16) of cases showed increased E-cadherin expression in the metastases compared to the primaries. [Mol Cancer]

Identification of High-Quality Cancer Prognostic Markers and Metastasis Network Modules
Researchers have developed an algorithm that identifies prognostic markers using tumour gene microarrays focusing on metastasis-driving gene expression signals. [Nat Commun]

CLINICAL RESEARCH

Nomogram for Predicting the Risk of Local Recurrence After Breast-Conserving Surgery for Ductal Carcinoma In Situ
Individualized estimation of ipsilateral breast tumor recurrence risk would assist in decision making regarding the various treatment options for women with ductal carcinoma in situ. [J Clin Oncol]

INDUSTRY NEWS

Novelos Therapeutics Announces Positive Phase II Results in NOV-002 Neoadjuvant Breast Cancer Trial at Sylvester Comprehensive Cancer Center, at the University of Miami
Novelos Therapeutics, Inc. announced positive results in a Phase II trial of NOV-002 in combination with neoadjuvant chemotherapy treatment in patients with stage IIB-IIIC HER-2/neu negative invasive breast cancer, conducted by the University of Miami Miller School of Medicine. [Novelos Therapeutics, Inc. Press Release]



POLICY NEWS

Harold Varmus Sworn in as National Cancer Institute’s 14th Director
Nobel Prize winner Harold E. Varmus, M.D., took the oath of office to become the National Cancer Institute’s (NCI) 14th director. NCI is one of the 27 Institutes and Centers that comprise the National Institutes of Health (NIH). [National Institutes of Health, United States]

Britain Delays Controversial Assessment Scheme for Research
Britain’s new science minister made good a manifesto pledge when he announced that the coalition government would delay for one year the implementation of the controversial Research Excellence Framework, a system of assessing university departments for the distribution of funding. [Ministry of Universities and Science, United Kingdom]

Spanish Science Spending Lockdown
Spain’s science and innovation minister said that research funding will be “frozen or minimally reduced” as a result of government-wide austerity measures. [Ministry of Science and Innovation, Spain]

Maryland Stem Cell Research Commission Elects Margaret Conn Himelfarb as Chair
The Maryland Stem Cell Research Commission announced that it has elected Margaret Conn Himelfarb as chair and Bowen P. Weisheit, Jr. as vice chair. [Maryland Stem Cell Research Commission, United States]

Clinical Laboratory Improvement Advisory Committee (CLIAC); Notice of Meeting [Centers for Disease Control and Prevention, United States]

Request for Information (RFI) on the National Institutes of Health Plan to Develop the Genetic Testing Registry; Notice [National Institutes of Health, United States]

Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting [National Institutes of Health, United States]



EVENTS

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

2010 Breast Cancer Symposium
October 1-3, 2010
Washington, DC, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

16th World Congress of the International Society of Senology
October 20-22, 2010
Valencia, Spain

The 2010 American Institute for Cancer Research (AICR) Annual Research Conference on Food, Nutrition, Physical Activity & Cancer
October 21-22, 2010
Washington, DC, United States

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom


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