Volume 2.25 | Jul 8

Mammary Cell News 2.25 July 8, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

A MicroRNA Targeting Dicer for Metastasis Control  ShareThis
Here, researchers identify a microRNA family, miR-103/107, that attenuates miRNA biosynthesis by targeting Dicer, a key component of the miRNA processing machinery. [Cell]

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SCIENCE NEWS

Men With Faulty Gene ‘Carry Breast Cancer Risk’
Men who carry a faulty gene have a one in 15 chance of getting breast cancer by the time they are 70, a study says. [Press release from BBC News discussing online prepublication in the Journal of Medical Genetics]

Mechanism Decoded by Which Olive Oil Protects Against Cancer
Researchers have discovered a mechanism by which virgin olive oil, in contrast to other vegetable oils, protects the body against breast cancer. [Press release from the Universitat Autònoma de Barcelona discussing online prepublication in Carcinogenesis]

Revolutionary Therapy Slows Tumor Growth in Advanced Breast Cancer, Penn Research Reports
A novel therapy designed to attack tumors in patients with a genetic mutation in either BRCA1 or BRCA2 , slowed tumor growth in 85 percent of advanced breast cancer patients treated in a small study. [Press release from the University of Pennsylvania School of Medicine discussing online prepublication in The Lancet]

Fewer than Half of Breast Cancer Patients Adhere to Hormonal Therapy Regimen, Study Finds
A new study of nearly 8,800 women with early-stage breast cancer found that fewer than half – approximately 49 percent – completed their full regimen of hormone therapy according to the prescribed schedule. [Press release from the American Society of Clinical Oncology discussing online prepublication in the Journal of Clinical Oncology]

Novel Molecular Pathway Regulates Invasive Growth and Metastasis in Estrogen Receptor-Positive Breast Cancer
A multi-disciplinary team of international researchers has uncovered a novel molecular pathway that regulates invasive growth and metastasis in estrogen receptor-positive breast cancer. [Press release from ScienceDaily discussing online prepublication in the Journal of the National Cancer Institute]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

The Role of SATB1 in Breast Cancer Pathogenesis
Researchers explored the potential of the SATB1 protein as a therapeutic target and prognostic marker for human breast cancer. [J Natl Cancer Inst]

ARRDC3 Suppresses Breast Cancer Progression by Negatively Regulating Integrin Beta4
In this study, reserachers examined the cellular effects and molecular mechanism of the arrestin family member, ARRDC3, a gene preferentially lost in a subset of breast cancers. [Oncogene]

The BH3-Only Protein Bad Confers Breast Cancer Taxane Sensitivity Through a Nonapoptotic Mechanism
In this paper, researchers report that the proapoptotic BH3-only protein Bad has a major role in taxane-induced cell death in vitro, and clinically is a prognostic indicator for overall survival of breast cancer patients after adjuvant taxane chemotherapy. [Oncogene]

Kif18A is Inolved in Human Breast Carcinogenesis
In this study, researchers report that Kif18A is overexpressed in human breast cancers and Kif18A overexpression is associated with tumor grade, metastasis and poor survival. [Carcinogenesis]

Coclustering of ErbB1 and ErbB2 Revealed by FRET-Sensitized Acceptor Bleaching
Here, researchers report the development of the fluorescence resonance energy transfer (FRET)-sensitized acceptor bleaching technique to quantitate the ratio of ErbB1 and ErbB2 in their heteroclusters. [Biophys J]

Mammosphere-Forming Cells from Breast Cancer Cell Lines as a Tool for the Identification of CSC-Like- and Early Progenitor-Targeting Drugs
Here, researchers show that a subpopulation of MCF-7 breast cancer cells which stains pale to Toluidine Blue, is endowed with features of cancer stem cells. [Cell Cycle]

CLINICAL RESEARCH

Early Discontinuation and Nonadherence to Adjuvant Hormonal Therapy in a Cohort of 8,769 Early-Stage Breast Cancer Patients
While studies have found that adjuvant hormonal therapy for hormone-sensitive breast cancer (BC) dramatically reduces recurrence and mortality, adherence to medications is suboptimal. Researchers investigated the rates and predictors of early discontinuation and nonadherence to hormonal therapy in patients enrolled in Kaiser Permanente of Northern California health system. [J Clin Oncol]



INDUSTRY NEWS

UC San Diego Researcher Awarded $5.3 Million for Breast Cancer Survivorship Study
The University of California, San Diego School of Medicine has received a $5.3 million grant from the National Cancer Institute to conduct and lead a first-of-its-kind, four-year clinical trial to show the effects of weight loss and increased physical activity on quality of life and on co-existing medical conditions in overweight breast cancer survivors. [The University of California, San Diego School of Medicine Press Release]

Calistoga Pharmaceuticals Raises $40 Million in Series C Financing
Calistoga Pharmaceuticals, Inc. announced it has closed a $40 million Series C financing. The funds will be used to advance Calistoga Pharmaceuticals’ drug development pipeline of isoform-selective phosphatidylinositol 3 kinase inhibitors. [Calistoga Pharmaceuticals Press Release]

Celgene to Acquire Abraxis BioScience Inc.
Celgene Corporation and Abraxis BioScience Inc. jointly announced the signing of a definitive merger agreement in which Celgene has agreed to acquire Abraxis BioScience. [Celgene Corporation Press Release]



POLICY NEWS

Research Budgets Face Austerity in 2012
The National Institutes of Health and other life sciences and biomedical research funding agencies will need to trim their budgets for 2012, which are to be planned over the summer, to satisfy a White House that is now stressing deficit reduction and belt-tightening after two years of stimulus funding-boosted research budgets. [The Office of Management and Budget, United States]

The Reality of Human Stem Cell Research in Europe
A new report from the European Science Foundation examines the key scientific questions for human stem cell research in the context of the rapidly emerging field of regenerative medicine. [European Science Foundation, European Union]

AstraZeneca Loses Generic Drug Case versus EU
A European Union (EU) court backed an EU antitrust decision against Anglo-Swedish drug maker AstraZeneca, lending weight to a regulatory crackdown on firms blocking cheaper drugs coming to market. [The General Court, European Union]

Strong Medicine for French Research
The medical-research adviser to France’s president aims to shift power and money to universities. [National Research Agency, France]

Meeting of the National Advisory Council for Healthcare Research and Quality [Agency for Healthcare Research and Quality, United States]

Maryland Stem Cell Research Commission – Public Meeting Notice [Maryland Stem Cell Research Commission, United States]

Center for Scientific Review; Notice of Closed Meetings [National Institutes of Health, United States]

Science Board Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001]  [Food and Drug Administration, United States]

Guidance for Industry: Adaptive Design Clinical Trials for Drugs and Biologics [Food and Drug Administration, United States]

Medical Devices; Availability of Safety and Effectiveness Summaries for Premarket Approval Applications [Docket Nos. FDA-2010-M-0068, FDA-2010-M-0078, FDA-2010-M-0063, FDA-2010-M-0135, FDA-2010-M-0158] [Food and Drug Administration, United States]



EVENTS

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

2010 Breast Cancer Symposium
October 1-3, 2010
Washington, DC, United States

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

16th World Congress of the International Society of Senology
October 20-22, 2010
Valencia, Spain

The 2010 American Institute for Cancer Research (AICR) Annual Research Conference on Food, Nutrition, Physical Activity & Cancer
October 21-22, 2010
Washington, DC, United States

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom


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