Volume 2.23 | Jun 17

Mammary Cell News 2.23 June 17, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

PIK3CA Mutations in In Situ and Invasive Breast Carcinomas
The results suggest that mutation of PIK3CA is an early event in breast cancer that is more likely to play a role in breast tumor initiation than in invasive progression, although a potential role for exon 9 mutations in the progression of a subset of ductal carcinoma in situ cases cannot be excluded. [Cancer Res]

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SCIENCE NEWS

Women Who Choose Boiled Coffee Run Lower Risk of Breast Cancer
Women who drink boiled coffee more than four times a day run a lower risk of developing breast cancer than women who drink coffee less than once a day. [Press release from Umea University discussing online prepublication in Cancer Causes & Control]

Angiotensin Receptor Blockers Linked to Cancer
Researchers have uncovered a troubling link between angiotensin-receptor blockers and cancers of the breast, prostate, and lung. [Press release from Canadian Broadcasting Corporation discussing online prepublication in Lancet Oncology]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

Powerful SNP-Set Analysis for Case-Control Genome-wide Association Studies (GWAS)
Researchers apply single nucleotide polymorphism (SNP)-set analysis to analyze the Cancer Genetic Markers of Susceptibility breast cancer GWAS discovery-phase data. [Am J Hum Genet]

The Transcription Factor REST Is Lost in Aggressive Breast Cancer
Here, researchers test the hypothesis that loss of RE1 silencing transcription factor (REST) function plays a role in breast cancer. [PLoS Genet]

Nuclear Alternate Estrogen Receptor GPR30 Mediates 17Beta-Estradiol-Induced Gene Expression and Migration in Breast Cancer-Associated Fibroblasts
In this report, researchers show that cancer-associated fibroblasts respond to physiologic concentrations of 17beta-estradiol by rapidly inducing extracellular signal-regulated kinase phosphorylation and immediate early gene expression, including c-fos and connective tissue growth factor, and cyclin D1. [Cancer Res]

Preneoplastic Changes Persist after IGF-IR Downregulation and Tumor Regression
Type I insulin-like growth factor receptor (IGF-IR)-targeting agents may be effective at regressing mammary tumors expressing IGF-IR, but these agents will not completely eradicate all tumor cells or restore the mammary stromal environment. [Oncogene]

miR-661 Expression in SNAI1-Induced Epithelial to Mesenchymal Transition Contributes to Breast Cancer Cell Invasion by Targeting Nectin-1 and StarD10 Messengers
The non-a priori approach revealed a nonpredicted link between SNAI1-triggered epithelial to mesenchymal transition and the down-regulation of Nectin-1 and StarD10 through the up-regulation of miR-661, which may contribute to the invasion of breast cancer cells and poor disease outcome. [Oncogene]

Inhibition of AP-1 by SARI Negatively Regulates Transformation Progression Mediated by CCN1
The results illustrate that SARI (suppressor of activator protein (AP)-1, regulated by interferon (IFN)) inhibits AP-1 transactivating factor binding to the cis-element of the CCN1 promoter, possibly through its interaction with c-Jun. [Oncogene]

Zinc Induces Structural Reorganization of Gelatin Binding Domain from Human Fibronectin and Affects Collagen Binding
Here, researchers present the 2.5-angstrom resolution crystal structure of fibronectin’s 45-kDa gelatin-binding domain, which also corresponds to the C-terminal half of the migration stimulating factor, a Fn splice variant expressed in human breast cancers. [Structure]

Progesterone Reverses the Mesenchymal Phenotypes of Basal Phenotype Breast Cancer Cells Via a Membrane Progesterone Receptor Mediated Pathway
The data suggest that the signaling cascade of progesterone induced mesenchymal repression is mediated through membrane progesterone receptor alpha and other caveolae bound signaling molecules namely caveolin-1, epidermal growth factor receptor, and PI3K. [Breast Cancer Res]

CLINICAL RESEARCH

Effect of Body Mass Index on Recurrences in Tamoxifen and Anastrozole Treated Women: An Exploratory Analysis From the ATAC Trial
The results suggest that the relative efficacy of anastrozole compared to tamoxifen is greater in thin postmenopausal women and higher doses or more complete inhibitors might be more effective in overweight women, but this requires independent confirmation. [J Clin Oncol]

Are Mastectomy Rates Really Increasing in the United States?
In contrast to single-institution studies, this population-based analysis found a decrease in unilateral mastectomy rates from 2000 to 2006 in the United States. [J Clin Oncol]

Angiotensin-Receptor Blockade and Risk of Cancer: Meta-Analysis of Randomised Controlled Trials
Researchers assessed whether angiotensin-receptor blockers affect cancer occurrence with a meta-analysis of randomised controlled trials of these drugs. [Lancet Oncol]



INDUSTRY NEWS

ExonHit Signs an Exclusive Agreement with Genmab for Novel Splice Variant Targets in Breast Cancer
ExonHit Therapeutics announced the signing of an exclusive agreement with Genmab A/S for a selection of novel splice variants, identified as part of a successful pilot study, that have the potential to be therapeutic targets for breast cancer. [ExonHit Therapeutics Press Release]

In Hungary JDC, Susan G. Komen For The Cure® Held 12th Major Breast Cancer Conference
The American Jewish Joint Distribution Committee (JDC) and Susan G. Komen for the Cure® held its 12th major conference on breast cancer in Budapest on June 14. [American Jewish Joint Distribution Committee Press Release]

Are Dead Cancer Cells Feeding Cancer’s Spread? UAB Awarded $805,000 Grant to Study the Issue
Researchers have won an $805,000 grant from the U.S. Department of Defense Breast Cancer Research Program to study whether dead cancer cells left over after treatment encourage cancer’s spread to other parts of the body. [University of Alabama at Birmingham Press Release]



POLICY NEWS

FDA Takes Issue with Genetic Tests from 23andMe, Four Other Firms
The Food and Drug Administration has put five genetic test makers on notice that they must get federal approval before marketing their products for use by consumers. [Food and Drug Administration, United States]

Diseased Cells Fail to Win Approval
In the latest obstacle to expanding the number of embryonic stem-cell lines eligible for US federal funding, a National Institutes of Health (NIH) committee has unanimously rejected dozens of cell lines carrying mutations for specific diseases. [National Institutes of Health, United States]

NIH Researchers Explore How Healthy, Young Adults View the Role Genetics Plays in Improving Health
Most healthy young adults place greater emphasis on health habits than on genetic risk factors when considering what causes common diseases, a research team from the National Human Genome Research Institute and the Henry Ford Health System in Detroit has found. [National Institutes of Health, United States]

Enhancing Peer Review: Advance Notice on Post-Submission Application Materials for NIH Training and Related Applications (NOT-OD-10-104) [National Institutes of Health, United States]

PFINDR: Phenotype Finder IN Data Resources: A Tool to Support Cross-Study Data Discovery Among NHLBI Genomic Studies (UH2/UH3) (RFA-HL-11-020) [National Institutes of Health, United States]

Clinical Trials for Medicines Section Updated [Medicines and Healthcare Products Regulatory Agency, United Kingdom]

Advertising and Supply of Therapeutic Goods to Complementary Healthcare Professionals: Schedule 1 to the Therapeutic Goods Regulations [Therapeutic Goods Administration, Australia]

Increased Transparency of the Prescription Medicine Regulatory Process [Therapeutic Goods Administration, Australia]



EVENTS

The 21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit
August 24-25, 2010
Edinburgh, Scotland

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom


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Sr. Product Support and Training Specialist (CardianBCT)

Manager/Sr. Manager, Therapeutic Cell Solutions, Process Development (Lonza)

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