Volume 2.20 | May 27

Mammary Cell News 2.20 May 27, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

RCSI Researchers Uncover Breakthrough in Predicting Severity of Breast Cancer
Researchers have identified a biomarker in patient blood which can predict the severity of breast cancer in patients and may enable clinicians to track patients throughout the course of their treatment. [Press release from the Royal College of Surgeons in Ireland discussing online prepublication in Cancer Research]

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SCIENCE NEWS

Subtyping Breast Cancer by Immunohistochemistry to Investigate Survival Terms
This study evaluates immunohistochemistry-based subtype classification of breast tumors for the prediction of disease outcome. [Press release from EurekAlert! discussing online prepublication in PLoS Medicine]

Prenatal Exposure To Endocrine-Disrupting Chemicals Linked To Breast Cancer
A study in mice reveals that prenatal exposure to endocrine-disrupting chemicals, like bisphenol-A (BPA) and diethylstilbestrol (DES), may program a fetus for life. Therefore, adult women who were exposed prenatally to BPA or DES could be at increased risk of breast cancer. [Press release from Biocompare discussing online prepublication in Hormones & Cancer]

New Cancer Vaccine Starves Tumours of Blood
A DNA-vaccine that restricts the supply of blood to tumours has been developed by scientists at the Swedish medical university Karolinska Institutet. [Press release from ScienceDaily discussing online prepublication in Oncogene]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

LABORATORY RESEARCH

The Actin-Bundling Protein Palladin Is an Akt1-Specific Substrate that Regulates Breast Cancer Cell Migration
Here, researchers identify palladin, an actin-associated protein, as an Akt1-specific substrate that modulates breast cancer cell invasive migration. [Mol Cell]

Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies
In this study, the researchers investigate the survival over time of women with six major subtypes of breast cancer classified using five immunohistochemical markers: the estrogen receptor and the progesterone receptor, the human epidermal growth factors receptor-2, and CK5/6 and epidermal growth factor receptor. [PLoS Med]

Vascular Robo4 Restricts Proangiogenic VEGF Signaling in Breast
Researchers identify a stromal, rather than epithelial, source of SLITs that inhibits blood vessel growth by signaling through endothelial ROBO4 to down-regulate VEGF/VEGFR2 signaling. [Proc Natl Acad Sci U S A]

PTPL1/PTPN13 Regulates Breast Cancer Cell Aggressiveness through Direct Inactivation of Src Kinase
By identification of protein tyrosine phosphatase 1 (PTPL1) as the first phosphatase able to inhibit Src through direct dephosphorylation in intact cells, researchers presently describe a new mechanism by which PTPL1 inhibits breast tumor aggressiveness. [Cancer Res]

Tetraspanin CD151 Regulates Growth of Mammary Epithelial Cells in Three-Dimensional Extracellular Matrix: Implication for Mammary Ductal Carcinoma In situ
Here, researchers examined the role of CD151 in proliferation of mammary epithelial cells using in vitro and in vivo models. [Cancer Res]

Deregulated Estrogen Receptor Alpha and p53 Heterozygosity Collaborate in the Development of Mammary Hyperplasia
Genetically engineered mouse models of deregulated ERalpha expression and p53 haploinsufficiency were used to investigate similarities and differences of each genetic lesion alone and in combination on mammary preneoplasia development. [Cancer Res]

Therapeutic Efficacy of a DNA Vaccine Targeting the Endothelial Tip Cell Antigen Delta-Like Ligand 4 in Mammary Carcinoma
Researchers have described a conceptually novel therapeutic strategy for targeting tumor angiogenesis and endothelial tip cells based on DNA vaccination against delta-like ligand 4. [Oncogene]

Expression of Estrogen Receptor Alpha Increases Leptin-Induced STAT3 Activity in Breast Cancer Cells
Here, researchers investigated cross-talk between estrogen receptor alpha and leptin-induced activation of signal transducer and activator of transcription 3 (STAT3), a transactivator of important oncogenes. [Int J Cancer]

In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer
Developmental programming of EZH2 is a novel mechanism by which in utero exposure to endocrine disruptors leads to epigenetic regulation of the mammary gland. [Hormones and Cancer]

CLINICAL RESEARCH

Phase III Multicenter Trial of Doxorubicin Plus Cyclophosphamide Followed by Paclitaxel Compared With Doxorubicin Plus Paclitaxel Followed by Weekly Paclitaxel As Adjuvant Therapy for Women With High-Risk Breast Cancer
This study compared disease-free survival obtained with two different regimens of adjuvant therapy in high-risk breast cancer. [ J Clin Oncol]

Metastatic Behavior of Breast Cancer Subtypes
Breast cancer subtypes are associated with distinct patterns of metastatic spread with notable differences in survival after relapse. [J Clin Oncol]



INDUSTRY NEWS

Rensselaer Polytechnic Institute Wins $2.45 Million Grant To Support Stem Cell Research
Rensselaer Polytechnic Institute and principal investigator Glenn Monastersky have been awarded a four-year $2.45 million grant from the New York Stem Cell Science Program of the Empire State Stem Cell Board. [Rensselaer Polytechnic Institute Press Release]

Maryland Stem Cell Research Commission Announces 42 Projects for Funding
The Maryland Stem Cell Research Commission has completed its evaluation of the 141 applications in response to its three official Requests for Applications during the FY 2010 funding cycle. [Maryland Stem Cell Research Commission Press Release]

HHMI Awards $79 Million for Science Education to Research Universities, Top Scientists
Howard Hughes Medical Institute (HHMI) announced new grants totaling $79 million that will help universities strengthen undergraduate and precollege science education nationwide. [Howard Hughes Medical Institute Press Release]

Abviva Details Patent Information for its Breast Cancer Risk Assessment Technology
Abviva, Inc., a biomedical company engaged in the development and commercialization of breast cancer related applications of Mammastatin, provided further details about worldwide patent protection for its breast cancer risk assessment technology. [Yahoo! Finance]



POLICY NEWS

Cancer Center Marks Signing of Act on Screenings for Breast, Cervical and Colorectal Cancer
The new measure gives statutory authority for breast, cervical and colorectal cancer screening programs to the Alabama Department of Public Health. [Alabama Department of Public Health, United States]

NIH Wants More (Not Total) Disclosure of Financial Conflicts
The federal government proposed an overhaul of regulations covering financial conflicts of interest in biomedical research. [National Institutes of Health, United States]

NIH Requests Comments on the Proposed Rule Applicable to Regulations on the Responsibility of Applicants for Promoting Objectivity in Research for which Public Health Service Funding is Sought and Responsible Prospective Contractors (NOT-OD-10-099) [National Institutes of Health, United States]

Notice of Format Clarification and Frequently Asked Questions (FAQs) for Funding Opportunity Announcement (FOA): RFA-HL-11-006, Next Generation Genetic Association Studies (U01) (NOT-HL-10-110) [National Institutes of Health, United States]

Responsibility of Applicants for Promoting Objectivity in Research for Which Public Health Service Funding Is Sought and Responsible Prospective Contractors; Proposed Rule (Docket Number: NIH-2010-0001) [National Institutes of Health, United States]

Charter of the Blood Products Advisory Committee (Update) [Food and Drug Administration, United States]

FDA Transparency Initiative: Draft Proposals for Public Comment Regarding Disclosure Policies of the U.S. Food and Drug Administration; Availability [Docket No. FDA-2009-N-0247] [Food and Drug Administration, United States]



EVENTS

American Society of Clinical Oncology (ASCO) Annual Meeting 2010
June 4-8, 2010
Chicago, United States

Gordon Research Conference: Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

12th Milan Breast Cancer Conference
June 16-18, 2010
Milan, Italy

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

The 21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom


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