Volume 2.17 | May 6

Mammary Cell News 2.17 May 6, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

PMH Breast Cancer Researchers Link Ovarian Hormone to Breast Stem Cells Growth
Cancer researchers have discovered that the ovarian hormone progesterone plays a pivotal role in altering breast stem cells, a finding that has important implications for breast cancer risk. [Press release from Princess Margaret Hospital discussing online prepublication in Nature]

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SPECIAL FEATURE

Complimentary Webinar Presented by STEMCELL Technologies Assays for Mammary Epithelial Stem Cells and Progenitors

Speaker: Dr. John Stingl, PhD, Cancer Research UK Cambridge Research Institute

Tuesday, May 11th at 3PM BST
Ideal for participants in Europe

Tuesday, May 11th at 9AM PST/12PM EST
Ideal for participants in the Americas

Wednesday, May 12th at 1PM Singapore Time
Ideal for participants in Asia-Pacific


SCIENCE NEWS

Biochemist Unlocks Gene’s Role in Breast-Tumour Growth
New research helps explain why breast-milk cells lose their structure, causing them to clump up in strange ways and sometimes become cancer tumors. [Press release from McGill University discussing online prepublication in Genes and Development]

Broccoli Component Limits Breast Cancer Stem Cells, U-M Study Finds
The study tested sulforaphane, a component of broccoli and broccoli sprouts, in both mice and cell cultures. Researchers found sulforaphane targeted and killed the cancer stem cells and prevented new tumors from growing. [Press release from University of Michigan discussing online prepublication in Clinical Cancer Research]

Second Cancers More Likely for Survivors of Early-Stage Breast Cancer if They Smoke
Women who survive early-stage breast cancer and smoke have an increased chance of developing a new second cancer in their other breast or elsewhere. [The Cancer Institute of New Jersey Press Release]

Risk Of Invasive Breast Cancer Predicted By Breakthrough Method
For the first time, scientists have discovered a way to predict whether women with ductal carcinoma in situ – the most common form of non-invasive breast cancer – are at risk of developing more invasive tumors in later years. [Press release from Medical News Today discussing online prepublication in the Journal of the National Cancer Institute]

Obese Women Diagnosed With Larger, Later Stage Breast Cancers
Obese women are more likely to have breast cancer detected at a later stage and to have lymph node metastases when diagnosed than women who are not obese. [Medical News Today Press Release]

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CURRENT PUBLICATIONS

LABORATORY RESEARCH

Progesterone Induces Adult Mammary Stem Cell Expansion
Here researchers show that the mammary stem cell pool increases 14-fold during maximal progesterone levels at the luteal dioestrus phase of the mouse. [Nature]

Primary Cilia Regulate Branching Morphogenesis during Mammary Gland Development
During mammary development, researchers find cilia on luminal epithelial, myoepithelial, and stromal cells during early branching morphogenesis when epithelial ducts extend into the fat pad and undergo branching morphogenesis. [Curr Biol]

Functionality of Unliganded VDR in Breast Cancer Cells: Repressive Action on CYP24 Basal Transcription
It is well-established that CYP24, an immediate target gene of VDR is upregulated by VDR ligands. This study is focused on the functional role of unliganded VDR by investigating the correlation between the expression of VDR protein and basal mRNA levels of CYP24 in breast cancer cell lines. [Mol Cell Biochem]

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells
In this study, researchers evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast cancer stem cells and its potential mechanism. [Clin Cancer Res]

Cytoplasmic Delivery of Liposomes into MCF-7 Breast Cancer Cells Mediated by Cell-Specific Phage Fusion Coat Protein
Earlier, researchers have shown that doxorubicin-loaded liposomes (Doxil) modified with a chimeric phage fusion coat protein specific towards MCF-7 breast cancer cells identified from a phage landscape library demonstrated a significantly enhanced association with target cells and an increased cytotoxicity. [Mol Pharm]

Breast Cancer Diagnosis Using a Microfluidic Multiplexed Immunohistochemistry Platform
Here, researchers report a microfluidics-based multiplexed immunohistochemistry platform that significantly improves immunohistochemistry performance in reduction of time and tissue consumption, quantification, consistency, sensitivity, specificity and cost-effectiveness. [PLoS ONE]

CLINICAL RESEARCH

Estrogen Alone in Postmenopausal Women and Breast Cancer Detection by Means of Mammography and Breast Biopsy
As the influence of estrogen alone on breast cancer detection is not established, researchers examined this issue in the Women’s Health Initiative trial, which randomly assigned 10,739 postmenopausal women with prior hysterectomy to conjugated equine estrogen (CEE; 0.625 mg/d) or placebo. [J Clin Oncol]

Phase I Study of Trastuzumab-DM1, a HER2 Antibody-Drug Conjugate, Given Every 3 Weeks to Patients With HER2-Positive Metastatic Breast Cancer
This first-in-human study of Tratuzmab-DM1 (T-DM1) evaluated safety, pharmacokinetics, and preliminary activity of T-DM1 in patients with advanced HER2-positive breast cancer. [J Clin Oncol]

Biomarker Expression and Risk of Subsequent Tumors After Initial Ductal Carcinoma In Situ Diagnosis
Researchers conducted a nested case-control study in a population-based cohort of 1162 women who were diagnosed with ductal carcinoma in situ and treated by lumpectomy alone from 1983 to 1994. [J Natl Cancer Inst]


INDUSTRY NEWS

North Central Cancer Treatment Group (NCCTG) to Conduct Phase II Study of Cell Therapeutics’ Brostallicin in Metastatic Triple Negative Breast Cancer
Cell Therapeutics, Inc. announced that the North Central Cancer Treatment Group plans to conduct a Phase II study of brostallicin in combination with cisplatin in patients with metastatic triple-negative breast cancer. [Cell Therapeutics, Inc. Press Release]

Provista Life Sciences Provides Independent Validation of Radient Pharmaceuticals’ Onko-SureTM Cancer Test
Radient Pharmaceuticals Corporation announced diagnostics development and commercialization firm Provista Life Sciences LLC has independently validated Radient Pharmaceuticals’ Onko-Sure in vitro diagnostic cancer test as a potential screening tool for breast cancer detection. [Marketwire]



POLICY NEWS

Hutchinson Center Receives $10.24 Million from National Institutes of Health for Latina Breast Cancer Research
The National Institutes of Health has awarded $10.24 million to Fred Hutchinson Cancer Research Center to lead a five-year study that aims to understand and prevent breast cancer disparities in Hispanic women. [Fred Hutchinson Cancer Research Center Press Release]

Science Panel Cuts Authorization Levels for Three COMPETES Agencies
The House of Representatives Science and Technology Committee scaled back proposed funding levels for three key science agencies as part of its reauthorization of the America COMPETES Act. [The House of Representatives Science and Technology Committee, United States]

Commission to Boost Research and Innovation by Making it Easier to Apply for and Manage European Union Grants
The European Commission has unveiled a plan to simplify the procedures for taking part in European Union-funded research projects. [European Research, Innovation and Science Commissioner, European Union]

Final Opportunity to Attend a 2010 NIH Regional Seminar on Program Funding & Grants Administration: Register Now for Portland, OR (June 24-25, 2010) (NOT-OD-10-092)  [National Institutes of Health, United States]

Frequently Asked Questions (FAQ) for: Centers of Research Translation (CORT) (P50) RFA-AR-11-002 { NOT-AR-10-035) [National Institutes of Health, United States]

Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Predoctoral Fellows in PharmD/PhD Programs (F31) (PA-10-178) [National Institutes of Health, United States]

Extension of Expiration Date for PA-07-277, PA-06-367, and PA-06-368: Research on Ethical Issues in Human Subjects Research (NOT-OD-10-086) [National Institutes of Health, United States]

Guidance for Industry: Requalification Method for Reentry of Blood Donors Deferred Because of Reactive Test Results for Antibody to Hepatitis B Core Antigen (Anti-HBc); Availability (Docket No. FDA-2008-D-0263) [Food and Drug Administration, United States]

Emerging Infectious Diseases: Evaluation to Implementation for Transfusion and Transplantation Safety and Quantitative Risk Assessment: Blood Safety and Availability; Public Workshops (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]



EVENTS

Breast Cancer Research 2010 Conference
May 18, 2010
London, United Kingdom

American Society of Clinical Oncology (ASCO) Annual Meeting 2010
June 4-8, 2010
Chicago, United States

Gordon Research Conference: Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

12th Milan Breast Cancer Conference
June 16-18, 2010
Milan, Italy

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

The 21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom




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