Volume 2.12 | Apr 1

Mammary Cell News 2.12 April 1, 2010.
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Duke Scientists Identify New Classification System for Breast Cancer
Patterns of gene expression in biological pathways activated in the development of breast cancer reveal many new subtypes of the disease. [Press release from Duke University discussing online prepublication in the Proceedings of the National Academy of Sciences]



Study Shows That Mutations In One Gene Cause Many Cancers
An important gene that normally protects the body against cancer can itself cause a variety of cancers depending on the specific mutation that damages it, according to a new study. [Press release from Ohio State University discussing online prepublication in Proceedings of the National Academy of Sciences]

Clues to Pregnancy-Associated Breast Cancer Found
Expression of inflammatory-related genes in breast tissue of women who have previously given birth may explain the aggressiveness and frequency of pregnancy-associated breast cancer, according to new research. [Press release from University of Illinois discussing online prepublication in Cancer Prevention Research]

Beta Blockers Help Improve Survival for Breast Cancer Patients
A pilot study carried out in Nottingham and Germany has found that breast cancer patients being treated with beta-blockers leads to a significant reduction in the spread of the cancer and better survival rates – meaning the treatment could potentially save many thousands of lives. [Nottingham University Press Release]




A Pathway-Based Classification of Human Breast Cancer
Here, researchers describe a classification scheme for human breast cancer making use of patterns of pathway activity to build on previous subtype characterizations using intrinsic gene expression signatures, to provide a functional interpretation of the gene expression data that can be linked to therapeutic options. [Proc Natl Acad Sci U S A]

Annexin A1 Regulates TGF(Beta) Signaling and Promotes Metastasis Formation of Basal-Like Breast Cancer Cells
Researchers show here that Annexin A1 (AnxA1) expression is associated with a highly invasive basal-like breast cancer subtype both in a panel of human breast cancer cell lines as in breast cancer patients and that AnxA1 is functionally related to breast cancer progression. [Proc Natl Acad Sci U S A]

T-Box 2 Represses NDRG1 Through an EGR1-Dependent Mechanism to Drive the Proliferation of Breast Cancer Cells
In this study researchers show that T-box 2 (TBX2) drives proliferation in breast cancer cells and this is abrogated after TBX2 small interfering RNA knockdown or after the expression of a dominant-negative TBX2 protein. [Oncogene]

MicroRNA-155 Functions as an OncomiR in Breast Cancer by Targeting the Suppressor of Cytokine Signaling 1 Gene
Researchers report that the tumor suppressor gene suppressor of cytokine signaling 1 (socs1) is an evolutionarily conserved target of miR-155 in breast cancer cells. [Cancer Res]

Genetic Screen Identifies Insulin-like Growth Factor Binding Protein 5 as a Modulator of Tamoxifen Resistance in Breast Cancer
Through a genome-wide RNA interference screen to discover genes responsible for tamoxifen resistance in vitro, researchers identified insulin-like growth factor binding protein 5 (IGFBP5) as a determinant of drug sensitivity. [Cancer Res]

The Core Circadian Gene Cryptochrome 2 Influences Breast Cancer Risk, Possibly by Mediating Hormone Signaling
Here, researchers report findings from genetic, epigenetic, loss-of-function, and transcriptional profiling analyses of Cryptochrome 2 (CRY2) in breast cancer. [Cancer Prev Res]


Association Between Mammographic Density and Age-Related Lobular Involution of the Breast
Mammographic density and lobular involution are both significant risk factors for breast cancer, but whether these reflect the same biology is unknown. Researchers examined the involution and density association in a large benign breast disease cohort. [J Clin Oncol]

A Phase I Study to Assess the Feasibility and Oncologic Safety of Axillary Reverse Mapping in Breast Cancer Patients
This study reported a phase I trial conducted in patients with cytologically documented axillary metastasis undergoing axillary lymph node dissection to determine the feasibility and oncologic safety of axillary reverse mapping. [Cancer]

Variation in Anastrozole Metabolism and Pharmacodynamics in Women with Early Breast Cancer
The purpose of this study was to define interindividual variation in anastrozole metabolism and pharmacodynamics among patients treated with the approved daily dose of 1 mg in a standard practice setting as adjuvant therapy for resected early breast cancer. [Cancer Res]


Ethicon Endo-Surgery Announces Receipt of Offer to Purchase Breast Care Business
Ethicon Endo-Surgery, Inc. announced it has received an irrevocable, unconditional offer from Devicor Medical Products, a portfolio company of GTCR Golder Rauner, LLC, to acquire its Breast Care business. [Ethicon Endo-Surgery, Inc. Press Release]

District Court Overturns Patents on Breast Cancer Genes
Some 20 percent of the human genome is already patented. But a court ruled yesterday that one company does not have the rights to some of its patents on two genes, BRCA1 and BRCA2 , commonly tested for mutations to determine risk for developing breast and ovarian cancer. [Scientific American]

Oral COTI-2 is Effective Against Aggressive Triple Negative Human Breast Cancer
Critical Outcome Technologies Inc. announced positive test results from a series of animal experiments carried out at a prominent Canadian cancer research facility with COTI-2 as a single agent against an aggressive strain of triple negative human breast cancer. [Critical Outcome Technologies Inc. Press Release]


Carl Wieman Chosen for White House Science Post
Physicist Carl Wieman has been picked to be associate director for science in the White House Office of Science and Technology Policy. [Office of Science and Technology Policy, United States]

Notice of Termination of Selected Research Training and Research Career Development Award Funding Opportunity Announcements (NOT-OD-10-069) [National Institutes of Health, United States]

Final Ruth L. Kirschstein National Research Service Award (Kirschstein-NRSA) Policy for Tuition, Fees, and Health Insurance on Training Grants and Fellowships (NOT-OD-10-073)
[National Institutes of Health, United States]

Government Accountability Office: FDA Needs Better Plans To Protect Public Health
The U.S. Food and Drug Administration is facing significant planning and management challenges that could affect its ability to protect the public health, according to a report by the Government Accountability Office. [Food and Drug Administration, United States]

Guidance for Industry on the Content and Format of the Dosage and Administration Section of Labeling for Human Prescription Drug and Biological Products; Availability (Docket No. FDA-2007-D-0201) [Food and Drug Administration, United States]

Advisory Committees; Technical Amendment (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]

Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practices; Public Workshop (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]


34th Annual Symposium of the American Society of Breast Disease (ASBD)
April 16-17, 2010
New York City, United States

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

BIT’s 3rd Annual World Cancer Congress 2010 – Breast Cancer Conference
April 25-27, 2010
Shanghai, China

IMPAKT Breast Cancer Conference
May 6-8, 2010
Brussels, Belgium

Breast Cancer Research 2010 Conference
May 18, 2010
London, United Kingdom

American Society of Clinical Oncology (ASCO) Annual Meeting 2010
June 4-8, 2010
Chicago, United States

Gordon Research Conference: Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

12th Milan Breast Cancer Conference
June 16-18, 2010
Milan, Italy

The 21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

International Symposium on Breast Cancer Prevention: Nutrition, Communications, Public Policy
October 18-19, 2010
West Lafayette, United States

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom


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