Volume 2.11 | Mar 25

Mammary Cell News 2.11, March 25, 2010.
In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

TOP STORY

Tests For Genes Don’t Predict Breast Cancer Better
Studying genes linked to breast cancer may someday lead to better treatments, but they do little to improve a doctor’s ability to predict who is likely to develop a tumor, researchers reported. [Press release from Reuters discussing online prepublication in The New England Journal of Medicine]

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SCIENCE NEWS

Another Perk of Painkillers? Decreased Hormone Levels May Reduce Cancer Risk
Postmenopausal women who regularly use aspirin and other analgesics have lower estrogen levels, which could contribute to a decreased risk of breast or ovarian cancer. [Press release from ScienceDaily discussing online prepublication in Cancer Epidemiology, Biomarkers & Prevention]

The Biomarkers Consortium Launches I-SPY 2 Breast Cancer Clinical Trial
The Biomarkers Consortium announced the launch of a highly anticipated clinical trial to help screen promising new drugs being developed for women with high risk, fast-growing breast cancers – women for whom an improvement over standard treatment could dramatically change the odds of survival. [The Biomarkers Consortium Press Release]

Scott & White Healthcare Researchers Studying Investigational Agent that Targets Breast Cancer
Researchers are studying an investigational agent that targets metastatic breast cancer to find if it can stop cancer cells from continuing to grow. [EurekAlert! Press Release]

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CURRENT PUBLICATIONS

LABORATORY RESEARCH

Dose-Dependent Induction of Distinct Phenotypic Responses to Notch Pathway Activation in Mammary Epithelial Cells
Researchers investigated the cellular basis for the heterogeneous responses to Notch pathway activation in 3D cultures of MCF-10A mammary epithelial cells. [Proc Natl Acad Sci U S A]

Integrin-Linked Kinase has a Critical Role in ErbB2 Mammary Tumor Progression: Implications for Human Breast Cancer
Here, researchers show that mammary epithelial disruption of integrin-linked kinase results in a profound block in mammary tumor induction. [Oncogene]

Artemin is Estrogen Regulated and Mediates Antiestrogen Resistance in Mammary Carcinoma
Researchers report that artemin (ARTN) is an estrogen-inducible gene. Meta-analysis of gene expression data sets showed that ARTN expression is positively correlated to estrogen receptor status in human mammary carcinoma. [Oncogene]

Potential Prognostic Value of Heat-Shock Protein 90 in the Presence of Phosphatidylinositol-3-Kinase Overexpression or Loss of PTEN, in Invasive Breast Cancers
Evaluating the expression of signaling molecule proteins from the mitogen-activated protein kinase pathway and the phosphatidylinositol-3-kinase pathway in invasive breast cancers may identify prognostic marker(s) associated with early relapse. [Breast Cancer Res]

Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation
Researchers have uncovered that growth factors binding to receptor tyrosine kinases lead to activation of a non-receptor tyrosine kinase, Ack1 (also known as ACK or TNK2), which directly phosphorylates AKT at an evolutionarily conserved tyrosine 176 in the kinase domain. [PLoS ONE]

Transient Tumor-Fibroblast Interactions Increase Tumor Cell Malignancy by a TGF-Beta Mediated Mechanism in a Mouse Xenograft Model of Breast Cancer
Here, researchers report a role for normal stroma fibroblasts in the progression of invasive tumors to metastatic tumors. [PLoS ONE]

Common Germ-Line Polymorphism of C1QA and Breast Cancer Survival
The purpose of this study was to investigate the association of single nucleotide polymorphism, rs172378, with expression of C1QA and breast cancer survival. [Br J Cancer]

CLINICAL RESEARCH

Performance of Common Genetic Variants in Breast-Cancer Risk Models
The inclusion of newly discovered genetic factors modestly improved the performance of risk models for breast cancer. The level of predicted breast-cancer risk among most women changed little after the addition of currently available genetic information. [N Engl J Med]

Breast Cancer Among the Oldest Old: Tumor Characteristics, Treatment Choices, and Survival
Women 80 years and older have breast cancer characteristics similar to those of younger women yet receive less aggressive treatment and experience higher mortality from early-stage breast cancer.  [J Clin Oncol]

Radiation Exposure, the ATM Gene, and Contralateral Breast Cancer in the Women’s Environmental Cancer and Radiation Epidemiology Study
Women who carry rare deleterious ATM missense variants and who are treated with radiation may have an elevated risk of developing contralateral breast cancer. [J Natl Cancer Inst]

Analgesic Use and Sex Steroid Hormone Concentrations in Postmenopausal Women
Prior epidemiologic studies suggest that regular use of analgesics may decrease risk of breast and ovarian cancer.  Researchers explored possible hormone-mediated mechanisms for these associations by examining the relationship between use of aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, and acetaminophen and sex steroid hormone concentrations among 740 postmenopausal women in the Nurses’ Health Study. [Cancer Epidemiol Biomarkers Prev]


INDUSTRY NEWS

Garnet BioTherapeutics Commences Treatment in GBT009 Trial for Incisional Wounds Following Breast Reconstruction Surgery
Garnet BioTherapeutics, Inc. announced that the first patient has been treated in a Phase II multicenter, double-blind, placebo-controlled study of its lead product candidate GBT009 at Unity Hospital in Rochester, New York. [The Medical News]

Lombardi Receives $7.5 Million in Federal Funding to Lead Breast Cancer-Focused Center for Cancer Systems Biology
Scientists at the Lombardi Comprehensive Cancer Center at Georgetown University Medical Center were awarded a five-year $7.5 million grant to tease apart, in the most comprehensive way ever devised, the role of a single protein receptor in breast cells in cancer development and treatment. [Lombardi Comprehensive Cancer Center Press Release]



POLICY NEWS

It’s The Law of The Land: Health Overhaul Signed
Claiming a historic triumph that could define his presidency, a jubilant Barack Obama signed a massive, nearly $1 trillion health care overhaul that will for the first time cement insurance coverage as the right of every U.S. citizen and begin to reshape the way virtually all Americans receive and pay for treatment. [United States Congress]

HHS Announces Additional $162 Million in Recovery Act Investment to Advance Widespread Meaningful Use of Health IT
U.S. Department of Health and Human Services (HHS) Secretary Kathleen Sebelius announced awards to help states facilitate health information exchange and advance health information technology (Health IT). [The Department of Health and Human Services, United States]

Instructions for Completion and Peer Review of the Vertebrate Animal Section in NIH Grant Applications and Cooperative Agreements (NOT-OD-10-027) [National Institutes of Health, United States]

Recovery Act: Update on American Recovery and Reinvestment Act Quarterly Reporting Requirements for Non-Competing Continuation Awards and Relinquished Projects; and Guidance to Avoid Common Errors (NOT-OD-10-065)
[National Institutes of Health, United States]

Recovery Act: Reminders on Annual Reporting Requirements and Notice of Revised Financial Closeout Requirements for American Recovery and Reinvestment Act-Funded Administrative Supplements and Competitive Revisions (NOT-OD-10-066) [National Institutes of Health, United States]

Recovery Act: Notice on the Proper Management of Recovery Act Spending to Promote Job Creation and Increase the Pace of Scientific Research; and Policy Limiting Second No-Cost Extensions to Recovery Act Grants (NOT-OD-10-067)
[National Institutes of Health, United States]

Amended NIH Policy on Submission of Late Grant Application Materials Prior to Initial Peer Review (NOT-OD-10-070) [National Institutes of Health, United States]

Modification: This Notice modifies RFA-RM-10-001 (NOT-RM-10-005) [National Institutes of Health, United States]

Modification to RFA-RM-09-019: Institutional Clinical and Translational Science Award (U54) (NOT-RM-10-006) [National Institutes of Health, United States]



EVENTS

34th Annual Symposium of the American Society of Breast Disease (ASBD)
April 16-17, 2010
New York City, United States

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

BIT’s 3rd Annual World Cancer Congress 2010 – Breast Cancer Conference
April 25-27, 2010
Shanghai, China

IMPAKT Breast Cancer Conference
May 6-8, 2010
Brussels, Belgium

Breast Cancer Research 2010 Conference
May 18, 2010
London, United Kingdom

American Society of Clinical Oncology (ASCO) Annual Meeting 2010
June 4-8, 2010
Chicago, United States

Gordon Research Conference: Mammary Gland Biology
June 6-11, 2010
Lucca (Barga), Italy

12th Milan Breast Cancer Conference
June 16-18, 2010
Milan, Italy

The 21st Meeting of the European Association for Cancer Research (EACR)
June 26-29, 2010
Oslo, Norway

United Kingdom National Stem Cell Network (UKNSCN) Third Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2010 World Cancer Congress
August 18-21, 2010
Shenzhen, China

15th Congress of the European Society of Surgical Oncology (ESSO)
September 15-17, 2010
Bordeaux, France

35th European Society for Medical Oncology (ESMO) Congress
October 8-12, 2010
Milan, Italy

6th National Cancer Research Institute (NCRI) Conference
November 7-10, 2010
Liverpool, United Kingdom




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