Volume 12.23 | June 18

2020-06-18 | MCN 12.23
Mammary Cell News by STEMCELL Technologies
Vol. 12.23 – 18 June, 2020

Loss of ZIP Facilitates JAK2-STAT3 Activation in Tamoxifen-Resistant Breast Cancer

Scientists used a powerful validation-based insertion mutagenesis method to find that expression of a dominant-negative, truncated form of the histone deacetylase ZIP led to resistance to tamoxifen.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

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Snail Promotes the Generation of Vascular Endothelium by Breast Cancer Cells

Investigators report a new and unexpected function of snail in endothelium generation by breast cancer cells. They showed that high snail-expressing breast cancer cells isolated from patients showed more endothelium generated from these cells.
[Cell Death & Disease]

Full Article

Contrasting DCIS and Invasive Breast Cancer by Subtype Suggests Basal-Like DCIS as Distinct Lesions

Scientists performed subtype stratified analyses and identified key differences between ductal carcinoma in situ and invasive breast cancer that suggested subtype specific progression.
[npj Breast Cancer]

Full Article

Mitochondrial Dysfunction Generates Aggregates That Resist Lysosomal Degradation in Human Breast Cancer Cells

Researchers demonstrated protein aggregates and autophagy receptors, TAX1BP1 and NDP52, as potential endpoints for monitoring autophagy during drug development and clinical studies.
[Cell Death & Disease]

Full Article

Oncogene PRR14 Promotes Breast Cancer through Activation of pI3K Signal Pathway and Inhibition of CHEK2 Pathway

Investigators showed PRR14 contributed to breast carcinogenesis mainly through overexpression, which derived from elevated transcription and gene amplification.
[Cell Death & Disease]

Full Article

Antitumor Effect of a WEE1 Inhibitor and Potentiation of Olaparib Sensitivity by DNA Damage Response Modulation in Triple-Negative Breast Cancer

Scientists investigated the antitumor effects of a WEE1 inhibitor and the mechanisms responsible for its effects on the cell cycle and DNA repair pathway as a monotherapy and in combination with a PARP inhibitor, an ATR inhibitor, and a DNA damage-inducing agent in six TNBC cell lines and in a Balb/c athymic nude mouse xenograft model.
[Scientific Reports]

Full Article

CRISPR/Cas9 Knockout of Human Arylamine N-Acetyltransferase 1 in MDA-MB-231 Breast Cancer Cells Suggests a Role in Cellular Metabolism

The authors provided evidence that N-acetyltransferase 1 was not just a xenobiotic metabolizing enzyme and might have a role in endogenous cellular metabolism.
[Scientific Reports]

Full Article

Regulation of Autophagy by Protein Kinase C-ε in Breast Cancer Cells

Researchers showed that protein kinase C-ε promoted breast cancer cell survival not only by inhibiting apoptosis but also by inducing autophagy.
[International Journal of Molecular Sciences]

Full Article

Rapid Cancer Diagnosis and Early Prognosis of Metastatic Risk Based on Mechanical Invasiveness of Sampled Cells

Investigators evaluated the mechanical invasiveness of established breast and pancreatic cell lines and of tumor-cells from fresh, suspected pancreatic cancer tumors. The mechanical invasiveness matched the in vitro metastatic potential in cell lines as determined with Boyden chamber assays.
[Annals of Biomedical Engineering]


Virtual Conference Exhibition: Pluripotent Stem Cells

Organoid Models for Mammary Gland Dynamics and Breast Cancer

The authors summarized key aspects of mammary gland biology and corresponding organoid models. The investigators also discussed emerging applications where organoids will be transformative for studying both the biology and diseases of the breast.
[Current Opinion in Cell Biology]



Verzenio® (abemaciclib) Significantly Reduced the Risk of Cancer Returning in People with High Risk HR+, HER2 Early Breast Cancer

Eli Lilly and Company announced Verzenio®, in combination with standard adjuvant endocrine therapy, has met the primary endpoint of invasive disease-free survival, significantly decreasing the risk of breast cancer recurrence or death compared to standard adjuvant endocrine therapy alone.

Press Release

Huge Open-Access Journal Deal Inked by University of California and Springer Nature

The University of California (UC) system announced it has signed the biggest open-access deal in North America with one of the largest commercial scientific publishers. The agreement with Springer Nature includes a commitment by the publisher to explore making all articles that UC corresponding authors publish in the Nature family of journals immediately free to read on publication starting in 2022.


Hong Kong’s Contentious National Security Law Concerns Some Academics

China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News]



Keystone eSymposia | Advances in Cancer Immunotherapy

2020-08-17 – 2020-08-19

> See All Events


Research Fellow – Molecular Pharmacology

Mayo Clinic – Rochester, Minnesota, United States

Postdoctoral Associate – Breast Cancer Research

University of Massachusetts Medical School – Worcester, Massachusetts, United States

Assistant Professor – Breast Cancer

Baylor College of Medicine – Houston, Texas, United States

Postdoctoral Fellow – Cancer Research

University of Oklahoma Health Science Center – Oklahoma City, Oklahoma, United States

Laboratory Research Technician – Breast Cancer

University of Vermont – Burlington, Vermont, United States

Staff Scientist – Cancer Systems Biology

City of Hope – Duarte, California, United States

Assistant Scientists – Cell Cycle Regulation

Georgetown University Medical Center – Washington, District of Columbia, United States

Postdoctoral Associate – Cancer Bioengineering

University of Pittsburgh – Pittsburgh, Pennsylvania, United States

Postdoctoral Scientist – Cancer Research Cluster

Cedars – Sinai medical School – Los Angeles, California, United States

> See All Jobs

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