| Mammary Cell News 10.05 February 8, 2018 | |
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TOP STORYDiet May Influence the Spread of a Deadly Type of Breast Cancer, Study Finds A single protein building block commonly found in food may hold a key to preventing the spread of an often-deadly type of breast cancer, according to a new multicenter study. [Press release from Cedars-Sinai discussing online prepublication in Nature] Press Release | Abstract |
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PUBLICATIONS(Ranked by impact factor of the journal)Cx26 promoted cancer stem cell self-renewal by forming a signaling complex with the pluripotency transcription factor NANOG and focal adhesion kinase (FAK), resulting in NANOG stabilization and FAK activation. This FAK/NANOG-containing complex was not formed in mammary epithelial or luminal breast cancer cells. [Nat Commun] Full Article | Press Release EGFR small interfering RNA (siRNA) was delivered into HER2-expressing cells by HER2/HER3 aptamer-induced internalization. HER2/HER3 aptamers acted as antagonist molecules for blocking HER2 and HER3 signaling pathways and also as tumor-targeting agents for siRNA delivery. [Mol Ther Nucleic Acids] Full Article The upregulation in EZH2, which is due to nicotine (NIC), was confirmed in breast carcinoma cell lines using 10 µM NIC, 1 µM DZNepA, and EZH2si. The upregulation of EZH2 was concomitant with upregulation in Myc and α9-nAChR. [Cell Death Dis] Full Article While tanshinone IIA (Tan IIA) did not inhibit heat shock protein 90 (Hsp90), it synergistically enhanced the antitumor efficacy of the Hsp90 inhibitors 17-AAG and ganetespib in human breast cancer MCF-7 cells. In addition, Tan IIA significantly inhibited PI3K/Akt/mTOR signaling, and induced both cell cycle arrest and autophagy. [Cell Death Dis] Full Article Scientists demonstrated the inhibitory effect of berberine on tumor growth and metastasis of triple negative breast cancer cells via suppression of TGF-β1 expression. [Cell Physiol Biochem] Full Article RNA-Seq Transcriptome Analysis of Breast Cancer Cell Lines under Shikonin Treatment Researchers performed transcriptome analysis using RNA-seq and explored the mechanism of action of shikonin in regulating the growth of different types of breast cancer cells. [Sci Rep] Full Article miR-539 Acts as a Tumor Suppressor by Targeting Epidermal Growth Factor Receptor in Breast Cancer Forced expression of miR-539 inhibited proliferation and migration of breast cancer MDA-MB-231 and MCF7 cells in vitro and suppressed tumor growth in vivo. [Sci Rep] Full Article Pre-Clinical Effects of Metformin and Aspirin on the Cell Lines of Different Breast Cancer Subtypes The breast cancer cell lines MCF-7, MDA-MB-231, and SK-BR-3 were treated with aspirin and/or metformin and functional in vitro assays were performed. [Invest New Drugs] Abstract PFKFB3 Is Involved in Breast Cancer Proliferation, Migration, Invasion and Angiogenesis Scientists investigated the specific role of 6-phosphofructo 2-kinase/fructose 2, 6-bisphosphatase 3 (PFKFB3) in breast cancer progression and its preliminary mechanisms of action. [Int J Oncol] Abstract The authors showed that the EphA2 receptor was differentially expressed in breast cancer cells and highly expressed in the HER2-negative breast cancer cell line MCF7. [Cancer Chemother Pharmacol] Abstract |
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REVIEWSMultifaceted Roles of Interleukin-6 in Adipocyte–Breast Cancer Cell Interaction Scientists summarize current understanding of the breast microenvironment, with emphasis on adipocytes as key players in breast cancer tumorigenesis. [Transl Oncol] Abstract Visit our reviews page to see a complete list of reviews in the mammary cell research field. |
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INDUSTRY NEWSBCRF Announces Expansion of the Drug Research Collaborative Ahead of World Cancer Day, the Breast Cancer Research Foundation (BCRF) announced a new, independent research project funded by grants from Astellas and Pfizer to advance understanding of the role of the androgen receptor in breast cancer. This will be part of BCRF’s previously established Drug Research Collaborative. Astellas and Pfizer are committing a total of $10 million in support. [Breast Cancer Research Foundation] Press Release Medical Prognosis Institute A/S spinout Oncology Venture AB announced the second interim report from the Phase II part of an ongoing LiPlaCis® Phase I/II study in hard to treat metastatic breast cancer patients. [Medical Prognosis Institute A/S] Press Release | |
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POLICY NEWSUS Science Agency Will Require Universities to Report Sexual Harassment Any institution receiving grant monies from the US National Science Foundation must now inform the agency if it finds that anyone funded by the grant proposal has committed sexual harassment. [Nature News] Editorial Breakthrough in Budget Negotiations Could Raise Spending for Science Top lawmakers in Congress announced a budget agreement that could produce substantial spending increases for research at key U.S. science agencies—and avoid a partial government shutdown. But the deal must still clear a few hurdles before it is finalized. [Science Insider] Editorial Peace is a dangerous cause to fight for in Turkey right now. In the latest blow to academics, eleven members of the Turkish Medical Association, including its president, Raşit Tükel, were arrested in early-morning raids. [Nature News] Editorial
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EVENTSNEW Preclinical and Personalized Breast Cancer Research NEW The New York Stem Cell Foundation (NYSCF) Conference 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Breast Cancer (University of Oxford) NEW Postdoctoral Scientist Opportunities – Biomedical Research (Cedars-Sinai) NEW Postdoctoral Fellow – Cancer Research (Memorial Sloan Kettering Cancer Center) Research Fellow – Breast Immunology (Dana-Farber Cancer Institute) Postdoctoral Fellow – Cancer Biology (University of Arkansas for Medical Science) Postdoctoral Research Associate – Cancer Biology (King’s College London) Postdoctoral Researcher – Development of Novel Cancer Therapies (University of Oxford) Cancer Bioinformatician – Breast Cancer Research (The Institute of Cancer Research) Postdoctoral Associate – Breast Cancer Research (University of Miami) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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